全文获取类型
收费全文 | 122篇 |
免费 | 9篇 |
专业分类
131篇 |
出版年
2019年 | 2篇 |
2016年 | 6篇 |
2015年 | 2篇 |
2014年 | 3篇 |
2013年 | 6篇 |
2012年 | 7篇 |
2011年 | 4篇 |
2010年 | 3篇 |
2009年 | 2篇 |
2008年 | 5篇 |
2007年 | 4篇 |
2004年 | 4篇 |
2002年 | 4篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1979年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1964年 | 1篇 |
1963年 | 4篇 |
1962年 | 1篇 |
1961年 | 3篇 |
1959年 | 3篇 |
1958年 | 3篇 |
1956年 | 3篇 |
1955年 | 2篇 |
1954年 | 1篇 |
1950年 | 1篇 |
1949年 | 1篇 |
1948年 | 1篇 |
1940年 | 1篇 |
1939年 | 2篇 |
1938年 | 1篇 |
1937年 | 1篇 |
1923年 | 2篇 |
1918年 | 4篇 |
1910年 | 2篇 |
1902年 | 2篇 |
1888年 | 1篇 |
排序方式: 共有131条查询结果,搜索用时 0 毫秒
81.
Filip Oulehle Christopher D. Evans Jenyk Hofmeister Radovan Krejci Karolina Tahovska Tryggve Persson Pavel Cudlin Jakub Hruska 《Global Change Biology》2011,17(10):3115-3129
Sulphur (S) and nitrogen (N) deposition are important drivers of the terrestrial carbon (C) and N cycling. We analyzed changes in C and N pools in soil and tree biomass at a highly acidified spruce site in the Czech Republic during a 15 year period. Total S deposition decreased from 5 to 1.1 g m?2 yr?1 between 1995 and 2009, whereas bulk N deposition did not change. Over the same period, C and N pools in the Oa horizon declined by 116 g C and 4.2 g N m?2 yr?1, a total decrease of 47% and 42%, respectively. This loss of C and N probably originated from organic matter (OM) that had accumulated during the period of high acid deposition when litter decomposition was suppressed. The loss of OM from the Oa horizon coincided with a substantial leaching (1.3 g N m?2 yr?1 at 90 cm) in the 1990s to almost no leaching (<0.02 g N m?2 yr?1) since 2006. Forest floor net N mineralization also decreased. This had consequences for spruce needle N concentration (from 17.1 to 11.4 mg kg?1 in current needles), an increase in litterfall C/N ratio (from 51 to 63), and a significant increase in the Oi + Oe horizon C/N ratio (from 23.4 to 27.3) between 1994 and 2009/2010. Higher forest growth and lower canopy defoliation was observed in the 2000s compared to the 1990s. Our results demonstrate that reducing S deposition has had a profound impact on forest organic matter cycling, leading to a reversal of historic ecosystem N enrichment, cessation of nitrate leaching, and a major loss of accumulated organic soil C and N stocks. These results have major implications for our understanding of the controls on both N saturation and C sequestration in forests, and other ecosystems, subjected to current or historic S deposition. 相似文献
82.
Sean W. Harshman Alessandro Canella Paul D. Ciarlariello Alberto Rocci Kitty Agarwal Emily M. Smith Tiffany Talabere Yvonne A. Efebera Craig C. Hofmeister Don M. Benson Jr. Michael E. Paulaitis Michael A. Freitas Flavia Pichiorri 《Proteomics》2013,13(20):3013-3029
Multiple myeloma (MM) is a hematological malignancy caused by a microenviromentally aided persistence of plasma cells in the bone marrow. The role that extracellular vesicles (EVs), microvesicles and exosomes, released by MM cells have in cell‐to‐cell communication and signaling in the bone marrow is currently unknown. This paper describes the proteomic content of EVs derived from MM.1S and U266 MM cell lines. First, we compared the protein identifications between the vesicles and cellular lysates of each cell line finding a large overlap in protein identifications. Next, we applied label‐free spectral count quantitation to determine proteins with differential abundance between the groups. Finally, we used bioinformatics to categorize proteins with significantly different abundances into functional groups. The results illustrate the first use of label‐free spectral counting applied to determine relative protein abundances in EVs. 相似文献
83.
Papakonstantinou E; Karakiulakis G; Eickelberg O; Perruchoud AP; Block LH; Roth M 《Glycobiology》1998,8(8):821-830
The formation of atherosclerotic lesions is characterized by invasion of
vascular smooth muscle cells (VSMC) into the tunica intima of the arterial
wall and subsequently by increased proliferation of VSMC, a process
apparently restricted to the intimal layer of blood vessels. Both events
are preceded by the pathological overexpression of several growth factors,
such as platelet-derived growth factor (PDGF) which is a potent mitogen for
VSMC and can induce their chemotaxis. PDGF is generally not expressed in
the normal artery but it is upregulated in atherosclerotic lesions. We have
previously shown that PDGF-BB specifically stimulates proliferating VSMC to
secrete a 340 kDa hyaluronic acid (HA-340). Here, we present evidence
regarding the biological functions of this glycan. We observed that HA-340
inhibited the PDGF-induced proliferation of human VSMC in a dose-dependent
manner and enhanced the PDGF-dependent invasion of VSMC through a basement
membrane barrier. These effects were abolished following treatment of
HA-340 with hyaluronidase. The effect of HA-340 on the PDGF-dependent
invasion of VSMC coincided with increased secretion of the 72-kDa type IV
collagenase by VSMC and was completely blocked by GM6001, a hydroxamic acid
inhibitor of matrix metalloproteinases. HA-340 did not exert any
chemotactic potency, nor did it affect chemotaxis of VSMC along a PDGF
gradient. In human atheromatic aortas, we found that HA- 340 is expressed
with a negative concentration gradient from the tunica media to the tunica
intima and the atheromatic plaque. Our findings suggest that HA-340 may be
linked to the pathogenesis of atherosclerosis, by modulating VSMC
proliferation and invasion.
相似文献
84.
G. Cufodontis L. Geitler L. Hofmeister F. Ehrendorfer 《Plant Systematics and Evolution》1956,103(2-3):376-380
Ohne Zusammenfassung 相似文献
85.
Ohne Zusammenfassung 相似文献
86.
Ohne Zusammenfassung 相似文献
87.
L. Hofmeister 《Plant Systematics and Evolution》1961,108(2):243-244
Ohne Zusammenfassung 相似文献
88.
89.
90.