首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   198篇
  免费   8篇
  国内免费   1篇
  2021年   2篇
  2020年   4篇
  2019年   5篇
  2018年   4篇
  2017年   5篇
  2016年   5篇
  2015年   4篇
  2014年   7篇
  2013年   3篇
  2012年   4篇
  2011年   11篇
  2010年   5篇
  2009年   3篇
  2008年   5篇
  2007年   2篇
  2006年   3篇
  2005年   5篇
  2004年   3篇
  2003年   2篇
  2002年   5篇
  2001年   11篇
  2000年   3篇
  1999年   4篇
  1998年   5篇
  1997年   2篇
  1996年   7篇
  1995年   2篇
  1992年   4篇
  1991年   2篇
  1988年   2篇
  1987年   2篇
  1986年   3篇
  1985年   6篇
  1984年   5篇
  1982年   3篇
  1980年   3篇
  1979年   3篇
  1978年   3篇
  1975年   6篇
  1974年   7篇
  1973年   5篇
  1972年   4篇
  1971年   2篇
  1968年   3篇
  1962年   3篇
  1961年   2篇
  1959年   4篇
  1958年   2篇
  1956年   1篇
  1955年   1篇
排序方式: 共有207条查询结果,搜索用时 0 毫秒
121.
A. Hoffer 《CMAJ》1973,108(2):186
A case is described of a young woman who first showed manifestations of schizophrenia in childhood. At the age of 13 years evidence was present of what was authoritatively diagnosed as a progressive degenerative cerebellar syndrome and her condition continued to deteriorate. Improvement commenced shortly after the institution of megavitamin therapy, notably nicotinic acid 3 grams daily. Her subsequent educational progress was satisfactory and her social rehabilitation is now complete. No medication other than nicotinic acid is required.  相似文献   
122.

Background  

Human insulin-like growth factor-I (hIGF-I) is a growth factor which is highly resemble to insulin. It is essential for cell proliferation and has been proposed for treatment of various endocrine-associated diseases including growth hormone insensitivity syndrome and diabetes mellitus. In the present study, an efficient plant expression system was developed to produce biologically active recombinant hIGF-I (rhIGF-I) in transgenic rice grains.  相似文献   
123.
124.
A novel approach to the design of sensitive fluorescent probes for nucleic acids detection is proposed. Suitable modifications of tri- and pentamethine cyanine dyes in the polymethine chain and/or in the heterocyclic residues can result in a significant decrease in unbound dye fluorescence intensity and an increase in dye emission intensity in the presence of DNA compared to the unsubstituted dye. The sharp enhancement in the fluorescence intensity upon dye interaction with double-stranded DNA permits the application of the modified tri- and pentamethine dyes as fluorescent probes in double-stranded DNA detection in homogeneous assays.  相似文献   
125.
The role of sexual dimorphic adipose tissue fat accumulation in the development of insulin resistance is well known. However, whether vitamin A status and/or its metabolic pathway display any sex- or depot (visceral/subcutaneous)-specific pattern and have a role in sexual dimorphic adipose tissue development and insulin resistance are not completely understood. Therefore, to assess this, 5 weeks old Wistar male and female rats of eight from each sex were provided either control or diabetogenic (high fat, high sucrose) diet for 26 weeks. At the end, consumption of diabetogenic diet increased the visceral fat depots (p < 0.001) in the males and subcutaneous depot (p < 0.05) in the female rats, compared to their sex-matched controls. On the other hand, it caused adipocyte hypertrophy (p < 0.05) of visceral depot (retroperitoneal) in the females and subcutaneous depot of the male rats. Although vitamin A levels displayed sex- and depot-specific increase due to the consumption of diabetogenic diet, the expression of most of its metabolic pathway genes in adipose depots remained unaltered. However, the mRNA levels of some of lipid droplet proteins (perilipins) and adipose tissue secretory proteins (interleukins, lipocalin-2) did display sexual dimorphism. Nonetheless, the long-term feeding of diabetogenic diet impaired the insulin sensitivity, thus affected glucose clearance rate and muscle glucose-uptake in both the sexes of rats. In conclusion, the chronic consumption of diabetogenic diet caused insulin resistance in the male and female rats, but did not corroborate with sexual dimorphic adipose tissue fat accumulation or its vitamin A status.  相似文献   
126.
Something Dangerous: Emergent and Changing Illicit Drug Use and Community Health . Merrill Singer. Long Grove, IL: Waveland Press, 2006. vi + 274 pp.  相似文献   
127.
128.
129.

Background  

The fatty acids of anaerobic ammonium oxidizing (anammox) bacteria contain linearly concatenated cyclobutane moieties, so far unique to biology. These moieties are under high ring strain and are synthesised by a presently unknown biosynthetic pathway.  相似文献   
130.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号