全文获取类型
收费全文 | 241篇 |
免费 | 19篇 |
出版年
2023年 | 4篇 |
2022年 | 6篇 |
2021年 | 7篇 |
2020年 | 3篇 |
2019年 | 15篇 |
2018年 | 15篇 |
2017年 | 11篇 |
2016年 | 14篇 |
2015年 | 7篇 |
2014年 | 20篇 |
2013年 | 22篇 |
2012年 | 13篇 |
2011年 | 18篇 |
2010年 | 12篇 |
2009年 | 12篇 |
2008年 | 8篇 |
2007年 | 10篇 |
2006年 | 11篇 |
2005年 | 14篇 |
2004年 | 10篇 |
2003年 | 5篇 |
2002年 | 5篇 |
2001年 | 1篇 |
2000年 | 5篇 |
1999年 | 1篇 |
1997年 | 1篇 |
1996年 | 4篇 |
1995年 | 1篇 |
1992年 | 2篇 |
1990年 | 2篇 |
1987年 | 1篇 |
排序方式: 共有260条查询结果,搜索用时 15 毫秒
31.
Essam Abdel-Salam Shaalan Deon Vahid Canyon Reinhold Muller Mohamed Wagdy Faried Younes Hoda Abdel-Wahab Abdel-Hamid Mansour 《Journal of vector ecology》2007,32(1):16-21
A twelve-month survey for mosquito predators was conducted in Townsville, Queensland, Australia, which is located in the arid tropics. The survey revealed the presence of five predaceous insects but only Anisops sp. (backswimmers) and Diplonychus sp. were common. Predatorial capacity and factors influencing this capacity were then assessed for adult Anisops sp. and adult and nymph stages of Diplonychus sp. against Culex annulirostris mosquito immatures under laboratory conditions. Predatorial capacity bioassays showed that adult Diplonychus sp. preyed upon both larval and pupal stages of Cx. annulirostris quite successfully. Nymphs of Diplonychus sp. proved to be more successful with smaller prey immatures, and Anisops sp adults did not prey successfully on any prey pupae. Increasing the foraging area and introducing aquatic vegetation significantly reduced the predatorial capacity of Diplonychus sp. nymphs, while only vegetation and not foraging area had a significant effect on adult Diplonychus sp. predation capacity. Overall, adult Diplonychus sp. proved to be a more efficient predator than Anisops sp., and field trials are now recommended to further assess the potential of Diplonychus sp. as a biocontrol agent. 相似文献
32.
Molecular,genetic and evolutionary analysis of a paracentric inversion in Arabidopsis thaliana 下载免费PDF全文
Paul Fransz Gabriella Linc Cheng‐Ruei Lee Saulo Alves Aflitos Jesse R. Lasky Christopher Toomajian Hoda Ali Janny Peters Peter van Dam Xianwen Ji Mateusz Kuzak Tom Gerats Ingo Schubert Korbinian Schneeberger Vincent Colot Rob Martienssen Maarten Koornneef Magnus Nordborg Thomas E. Juenger Hans de Jong Michael E. Schranz 《The Plant journal : for cell and molecular biology》2016,88(2):159-178
Chromosomal inversions can provide windows onto the cytogenetic, molecular, evolutionary and demographic histories of a species. Here we investigate a paracentric 1.17‐Mb inversion on chromosome 4 of Arabidopsis thaliana with nucleotide precision of its borders. The inversion is created by Vandal transposon activity, splitting an F‐box and relocating a pericentric heterochromatin segment in juxtaposition with euchromatin without affecting the epigenetic landscape. Examination of the RegMap panel and the 1001 Arabidopsis genomes revealed more than 170 inversion accessions in Europe and North America. The SNP patterns revealed historical recombinations from which we infer diverse haplotype patterns, ancient introgression events and phylogenetic relationships. We find a robust association between the inversion and fecundity under drought. We also find linkage disequilibrium between the inverted region and the early flowering Col‐FRIGIDA allele. Finally, SNP analysis elucidates the origin of the inversion to South‐Eastern Europe approximately 5000 years ago and the FRI‐Col allele to North‐West Europe, and reveals the spreading of a single haplotype to North America during the 17th to 19th century. The ‘American haplotype’ was identified from several European localities, potentially due to return migration. 相似文献
33.
MOTIVATION: In two-color microarray experiments, well-known differences exist in the labeling and hybridization efficiency of Cy3 and Cy5 dyes. Previous reports have revealed that these differences can vary on a gene-by-gene basis, an effect termed gene-specific dye bias. If uncorrected, this bias can influence the determination of differentially expressed genes. RESULTS: We show that the magnitude of the bias scales multiplicatively with signal intensity and is dependent on which nucleotide has been conjugated to the fluorescent dye. A method is proposed to account for gene-specific dye bias within a maximum-likelihood error modeling framework. Using two different labeling schemes, we show that correcting for gene-specific dye bias results in the superior identification of differentially expressed genes within this framework. Improvement is also possible in related ANOVA approaches. AVAILABILITY: A software implementation of this procedure is freely available at http://cellcircuits.org/VERA 相似文献
34.
35.
Shadia A. Galal Amira S. Abd El-All Mohamed M. Abdallah Hoda I. El-Diwani 《Bioorganic & medicinal chemistry letters》2009,19(9):2420-2428
A new series of potent antitumor and antiviral benzofuran derivatives was synthesized by the reaction of the furochromone-6-carboxaldehydes 1 and 2 with different heterocyclic amines to yield the benzofuran-5-carbonyl derivatives 4–11. The synthesized compounds 1, 3–11 were tested against twelve different human cancer cell lines and all of the compounds were more potent than the comparative standards. The HIV inhibitory activity of the tested compounds 1, 3–11 showed that they have higher potency than Atevirdine. Moreover, compound 6 was significantly potent with wider therapeutic index. The HIV-1 RT inhibitory activity showed that compounds 10, 11, 3 and 4 were notably potent but with lower therapeutic index than Atevirdine. The HCV NS3-4A protease inhibitor activity of the tested compounds revealed that they have weaker potency and less therapeutic index than VX-950, although compounds 1, 4, 9 and 6, respectively exhibited significant activity. 相似文献
36.
37.
Wael A. El-Sayed Walaa I. El-Sofany Hoda A. R. Hussein Nahed M. Fathy 《Nucleosides, nucleotides & nucleic acids》2017,36(7):474-495
New [(Indolyl)pyrazolyl]-1,3,4-oxadiazole compounds and their derived thioglycosides as well as the corresponding sugar hydrazones were synthesized. The acyclo C-nucleoside analogs of the oxadiazoline base system were also prepared by reaction of acid hydrazides with aldehydo sugars followed by one pot process encompassing acetylation and cyclization of the synthesized hydrazones. The anticancer activity of the newly synthesized compounds was studied against colorectal carcinoma (HCT116), breast adenocarcinoma (MCF7) and prostate cancer (PC3) human tumor cell lines and a number of compounds showed moderate to high activities. 相似文献
38.
Joseph S. Baxter Nichola Johnson Katarzyna Tomczyk Andrea Gillespie Sarah Maguire Rachel Brough Laura Fachal Kyriaki Michailidou Manjeet K. Bolla Qin Wang Joe Dennis Thomas U. Ahearn Irene L. Andrulis Hoda Anton-Culver Natalia N. Antonenkova Volker Arndt Kristan J. Aronson Annelie Augustinsson Olivia Fletcher 《American journal of human genetics》2021,108(7):1190-1203
39.
Bentol Hoda Modirroosta Masoud Tohidfar Jalal Saba Foad Moradi 《Functional & integrative genomics》2014,14(1):237-244
Compositional studies comparing transgenic with non-transgenic counterpart plants are almost universally required by governmental regulatory bodies. In the present study, two T2 transgenic cotton lines containing chitinase (Line 11/57) and Bt lines (Line 61) were compared with non-transgenic counterpart. To do this, biochemical characteristics of leaves and seeds, including amino acids, fatty acids, carbohydrates, anions, and cations contents of the studied lines were analyzed using GC/MS, high-performance liquid chromatography (HPLC), and ion chromatography (IC) analyzers, respectively. polymerase chain reaction (PCR) and Western blot analyses confirmed the presence and expression of Chi and Bt genes in the studied transgenic lines. Although, compositional analysis of leaves contents confirmed no significant differences between transgenic and non-transgenic counterpart lines, but it was shown that glucose content of chitinase lines, fructose content of transgenic lines (Bt and chitinase) and asparagine and glutamine of chitinase lines were significantly higher than the non-transgenic counterpart plants. Both the transgenic lines (Bt and chitinase) showed significant decrease in the amounts of sodium in comparison to the non-transgenic counterpart plants. The experiments on the seeds showed that histidine, isoleucine, leucine, and phenylalanine contents of all transgenic and non-transgenic lines were the same, whereas other amino acids were significantly increased in the transgenic lines. Surprisingly, it was observed that the concentrations of stearic acid, myristic acid, oleic acid, and linoleic acid in the chitinase line were significantly different than those of non-transgenic counterpart plants, but these components were the same in both Bt line and its non-transgenic counterpart. It seems that more changes observed in the seed contents than leaves is via this point that seeds are known as metabolites storage organs, so they show greater changes in the metabolites contents comparing to the leaves. 相似文献
40.
Shima Habibi Hassan Jamshidian Mahdi Kadivar Mohammad Reza Eshraghian Mohammad Hassan Javanbakht Hoda Derakhshanian Mahmoud Djalali 《Reports of Biochemistry & Molecular Biology》2014,2(2):70-75