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131.
The renin-angiotensin system (RAS) has been identified recently in elasmobranch fish, and the structure of angiotensin II (ANG II) is unusual ([Asp(1),Pro(3),Ile(5)]-ANG II) compared to other vertebrates. Receptors for ANG II have been identified in blood vessels and in a variety of osmoregulatory tissues including the gill, kidney and rectal gland. In addition, there is considerable binding to the interrenal gland and the stimulation of 1alpha-hydroxycorticosterone production in vitro suggests a physiological role in corticosteroidogenesis. ANG II is a potent vasoconstrictor and this effect does not appear to be mediated by sympathetic activation or catecholamine release. Although the RAS may not be involved in maintaining basal blood pressure, it may be important in situations in which blood pressure is reduced. Understanding of the role of ANG II as an osmoregulatory hormone is only just emerging with putative roles in the control of gill, rectal gland and perhaps, drinking. In addition, the stimulation of corticosteroid secretion may provide another means of controlling osmoregulation. J. Exp. Zool. 284:526-534, 1999. 相似文献
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Epidermal growth factor signals attenuate phenotypic and functional development of neocortical GABA neurons 下载免费PDF全文
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Hisato Ikegaya Takahisa Hayashi Tomomi Kaku Kazuyoshi Iwata Seiji Sonobe Teruo Shimmen 《Phycological Research》2008,56(3):216-222
By methylation analysis, it was found that the cell walls of Spirogyra contained 4,6-linked glucose, 4-linked glucose and terminal xylose, which could be components of xyloglucan. Immunocytochemical analysis was carried out using an anti-serum against xyloglucan. After removal of pectic substances, the cell walls of both rhizoid cells and inner cells were stained. Crude protein extract from Spirogyra had a hydrolase activity for xyloglucans. In addition, the exogenously applied xyloglucan prevented the detachment of the cell wall of the severed cell. Involvement of xyloglucan-like polysaccharide in cell–cell attachment was discussed. 相似文献
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Yanagida-Ishizaki Y Takei T Ishizaki R Imakagura H Takahashi S Shin HW Katoh Y Nakayama K 《Cell structure and function》2008,33(1):91-100
Tom1 (target of Myb 1) and its related proteins (Tom1L1/Srcasm and Tom1L2) constitute a protein family, which share an N-terminal VHS (Vps27, Hrs and STAM) domain and a following GAT (GGA and Tom1) domain. Tom1L1 has potential binding sequences for Tsg101, which is one of key regulators of the multivesicular body (MVB) formation. To obtain a clue to the role of Tom1L1 in the MVB formation, we have characterized the Tom1L1-Tsg101 interaction. We have found that not only the PTAP sequence in the GAT domain but also the PSAP sequence in the C-terminal region of Tom1L1 is responsible for its interaction with the UEV domain of Tsg101 and competes with the HIV-1 Gag protein for the Tsg101 interaction. Furthermore, we show that, by means of Tsg101, Tom1L1 associates with the midbody during cytokinesis as well as endosomes. Taken into account the topological equivalency among the events of the MVB formation, viral egress from the cell, and cytokinesis, the data obtained here suggest that Tom1L1 is implicated in these three distinct cellular processes. 相似文献
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The Senescence-accelerated Mouse (SAM): A Higher Oxidative Stress and Age-dependent Degenerative Diseases Model 总被引:1,自引:0,他引:1
Chiba Y Shimada A Kumagai N Yoshikawa K Ishii S Furukawa A Takei S Sakura M Kawamura N Hosokawa M 《Neurochemical research》2009,34(4):679-687
The SAM strain of mice is actually a group of related inbred strains consisting of a series of SAMP (accelerated senescence-prone)
and SAMR (accelerated senescence-resistant) strains. Compared with the SAMR strains, the SAMP strains show a more accelerated
senescence process, a shorter lifespan, and an earlier onset and more rapid progress of age-associated pathological phenotypes
similar to human geriatric disorders. The higher oxidative stress status observed in SAMP mice is partly caused by mitochondrial
dysfunction, and may be a cause of this senescence acceleration and age-dependent alterations in cell structure and function.
Based on our recent observations, we discuss a possible mechanism for mitochondrial dysfunction resulting in the excessive
production of reactive oxygen species, and a role for the hyperoxidative stress status in neurodegeneration in SAMP mice.
These SAM strains can serve as a useful tool to understand the cellular mechanisms of age-dependent degeneration, and to develop
clinical interventions.
Special issue article in honor of Dr. Akitane Mori. 相似文献