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排序方式: 共有291条查询结果,搜索用时 31 毫秒
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Cytotechnology - We found that strawberry extract suppressed immunoglobulin (Ig) E production in vitro and in vivo, and identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as one of the IgE... 相似文献
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Tsuguru Fujii Hiroaki Abe Munetaka Kawamoto Susumu Katsuma Yutaka Banno Toru Shimada 《Insect biochemistry and molecular biology》2013,43(7):594-600
Albino (al) is a lethal mutant of Bombyx mori that exhibits a colourless cuticle after the first ecdysis and dies without feeding on mulberry. Previous studies have indicated that sclerotisation was insufficient because of defective phenylalanine and tyrosine metabolism in albino larvae. However, the genetic mechanism underlying the albino phenotype has not been determined. Dopamine plays a central role in insect cuticle colouration and sclerotisation. The pathway for dopamine biosynthesis from phenylalanine involves phenylalanine hydroxylase (PAH; EC 1.14.16.1) and tyrosine hydroxylase (TH; EC 1.14.16.2). Tetrahydrobiopterin (BH4) is an essential cofactor of aromatic amino acid hydroxylases, including PAH and TH. Thus, BH4 is indispensable for cuticle colouration and sclerotisation. Here we report on identifying mutations in the gene that encodes for the Bombyx homolog of 6-pyruvoyl-tetrahydropterin synthase (PTS) which is involved in the biosynthesis of BH4, in 2 strains with different al alleles. In strain a60 (al), a transposable element was inserted in exon 2 of BmPTS. In strain a61 (al2), an 11-bp deletion was identified in the exon 2 region of BmPTS. After oral administration of BH4 to the al2 larvae, the survival rate was effectively increased and the larval integument was pigmented. These results indicated that BmPTS was responsible for the albino mutants of B. mori. We conclude that (i) a mutation in BmPTS leads to an insufficient supply of BH4 and results in defective dopamine biosynthesis and (ii) lack of dopamine results in cuticle colouration and sclerotisation failure. Lemon (lem) is a BH4-deficient mutant. It has been reported that de novo synthesis of zygotic BH4 was indispensable for viability of the embryo in eggs laid by lem (lem/leml) females. We found that lem/lem, al2/al2 larvae produced by lem (lem/lem) females were viable during the first instar stage, suggesting that al2/al2 embryo could synthesis BH4 by using maternally transmitted BmPTS. 相似文献
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Sato I Arima H Ozaki N Ozaki N Watanabe M Goto M Shimizu H Hayashi M Banno R Nagasaki H Oiso Y 《FEBS letters》2007,581(25):4857-4864
Peripheral administration of baclofen significantly reduced food intake and body weight increase in both diabetic (db/db) and diet-induced obese mice for 5 weeks, whereas it had no significant effects on energy balance in their lean control mice. Despite the decreased body weight, neuropeptide Y expression in the arcuate nucleus was significantly decreased, whereas pro-opiomelanocortin expression was significantly increased by baclofen treatment. These data demonstrate that the inhibitory effects of baclofen on body weight in the obese mice were mediated via the arcuate nucleus at least partially, and suggest that GABA(B) agonists could be a new therapeutic reagent for obesity. 相似文献
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Chika Kubota Takashi Okada Branko Aleksic Yukako Nakamura Shohko Kunimoto Mako Morikawa Tomoko Shiino Ai Tamaji Harue Ohoka Naomi Banno Tokiko Morita Satomi Murase Setsuko Goto Atsuko Kanai Tomoko Masuda Masahiko Ando Norio Ozaki 《PloS one》2014,9(8)
Background
The Edinburgh Postnatal Depression Scale (EPDS) is a widely used screening tool for postpartum depression (PPD). Although the reliability and validity of EPDS in Japanese has been confirmed and the prevalence of PPD is found to be about the same as Western countries, the factor structure of the Japanese version of EPDS has not been elucidated yet.Methods
690 Japanese mothers completed all items of the EPDS at 1 month postpartum. We divided them randomly into two sample sets. The first sample set (n = 345) was used for exploratory factor analysis, and the second sample set was used (n = 345) for confirmatory factor analysis.Results
The result of exploratory factor analysis indicated a three-factor model consisting of anxiety, depression and anhedonia. The results of confirmatory factor analysis suggested that the anxiety and anhedonia factors existed for EPDS in a sample of Japanese women at 1 month postpartum. The depression factor varies by the models of acceptable fit.Conclusions
We examined EPDS scores. As a result, “anxiety” and “anhedonia” exist for EPDS among postpartum women in Japan as already reported in Western countries. Cross-cultural research is needed for future research. 相似文献100.
Koji Iihara Kunihiro Nishimura Akiko Kada Jyoji Nakagawara Kuniaki Ogasawara Junichi Ono Yoshiaki Shiokawa Toru Aruga Shigeru Miyachi Izumi Nagata Kazunori Toyoda Shinya Matsuda Yoshihiro Miyamoto Akifumi Suzuki Koichi B. Ishikawa Hiroharu Kataoka Fumiaki Nakamura Satoru Kamitani 《PloS one》2014,9(5)