全文获取类型
收费全文 | 188篇 |
免费 | 12篇 |
出版年
2021年 | 2篇 |
2020年 | 2篇 |
2019年 | 3篇 |
2018年 | 2篇 |
2017年 | 3篇 |
2016年 | 7篇 |
2015年 | 7篇 |
2014年 | 6篇 |
2013年 | 17篇 |
2012年 | 13篇 |
2011年 | 18篇 |
2010年 | 9篇 |
2009年 | 4篇 |
2008年 | 5篇 |
2007年 | 12篇 |
2006年 | 10篇 |
2005年 | 9篇 |
2003年 | 6篇 |
2002年 | 5篇 |
2001年 | 1篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1991年 | 2篇 |
1989年 | 1篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 5篇 |
1985年 | 1篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1968年 | 2篇 |
1967年 | 1篇 |
1964年 | 1篇 |
1962年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有200条查询结果,搜索用时 937 毫秒
41.
42.
Hilmar Meissi 《Biology of the cell / under the auspices of the European Cell Biology Organization》1997,89(9):549-554
Light absorbed by a photopigment in a photoreceptor cell causes a photochemical reaction converting the 11-cis retinal chromophore into the all-trans configuration. These changes lead to a series of events that causes cGMP hydrolysis, a following decrease of cGMP in the cytoplasm of the photoreceptor outer segment and a closure of cGMP-gated cationic channels. As a consequence of these processes the membrane hyperpolarizes. In pineal photoreceptor cells of lower vertebrates these processes are only partly investigated. Molecules involved in the phototransduction process and the desensitization, like opsin, vitamin A, α-transducin and arrestin, have been immunocytochemically localized in pineal photoreceptors and also electrophysiological studies have shown that phototransduction mechanisms in pineal photoreceptors might be very similar to those found in retinal photoreceptors. This review will summarize some of the current knowledge on pineal photoreception and compare it with retinal processes. 相似文献
43.
Ellen Knierim Hiromi Hirata Nicole?I. Wolf Susanne Morales-Gonzalez Gudrun Schottmann Yu Tanaka Sabine Rudnik-Sch?neborn Mickael Orgeur Klaus Zerres Stefanie Vogt Anne van?Riesen Esther Gill Franziska Seifert Angelika Zwirner Janbernd Kirschner Hans?Hilmar Goebel Christoph Hübner Sigmar Stricker David Meierhofer Werner Stenzel Markus Schuelke 《American journal of human genetics》2016,98(3):473-489
44.
Nomi L. Harris Peter J. A. Cock Hilmar Lapp Brad Chapman Rob Davey Christopher Fields Karsten Hokamp Monica Munoz-Torres 《PLoS computational biology》2016,12(2)
The Bioinformatics Open Source Conference (BOSC) is organized by the Open Bioinformatics Foundation (OBF), a nonprofit group dedicated to promoting the practice and philosophy of open source software development and open science within the biological research community. Since its inception in 2000, BOSC has provided bioinformatics developers with a forum for communicating the results of their latest efforts to the wider research community. BOSC offers a focused environment for developers and users to interact and share ideas about standards; software development practices; practical techniques for solving bioinformatics problems; and approaches that promote open science and sharing of data, results, and software. BOSC is run as a two-day special interest group (SIG) before the annual Intelligent Systems in Molecular Biology (ISMB) conference. BOSC 2015 took place in Dublin, Ireland, and was attended by over 125 people, about half of whom were first-time attendees. Session topics included “Data Science;” “Standards and Interoperability;” “Open Science and Reproducibility;” “Translational Bioinformatics;” “Visualization;” and “Bioinformatics Open Source Project Updates”. In addition to two keynote talks and dozens of shorter talks chosen from submitted abstracts, BOSC 2015 included a panel, titled “Open Source, Open Door: Increasing Diversity in the Bioinformatics Open Source Community,” that provided an opportunity for open discussion about ways to increase the diversity of participants in BOSC in particular, and in open source bioinformatics in general. The complete program of BOSC 2015 is available online at http://www.open-bio.org/wiki/BOSC_2015_Schedule.Open in a separate window 相似文献
45.
46.
47.
Odd Terje Sandlund Hilmar J. Malmquist Bror Jonsson Skúli Skúlason Sigurdur S. Snorrason Pétur M. Jónasson Rolf Gydemo Torfinn Lindem 《Environmental Biology of Fishes》1988,23(3):183-195
Synopsis Population densities of age-0 arctic chaff in the surf zone averaged 1.83 and 4.70 fish m-2 in August 1984 and June 1985, respectively. Length variation of the littoral fish was low in early summer, increasing in
late summer and autumn. Newly emerged charr, ∼ 20 mm long, appeared in the stony shallow water zone during both May and June.
From length variation and variation in mouth position of the young charr, it is concluded that at least two of the four chaff
morphs in the lake are present in the surf zone during spring and summer. In August, some of the larger age-0 charr had moved
out from the surf zone, into the pelagic and the deeper epibenthic waters. The food of young littoral charr was dominated
by large chironomid larvae (instar 3 and 4) and pupae
Contribution from the Thingvallavatn project 相似文献
48.
Olav Hilmar Iversen 《Virchows Archiv. B, Cell pathology including molecular pathology》1978,28(1):93-95
The epidermal cell kinetics in nude mice is investigated by determining the mitotic rate and the mitotic count, the H3Tdr labelling index, and the proportion of basal cells in the different cell cycle phases by flow cytometry. The mitotic duration was calculated. The parameter values of the epidermal cell kinetics of the nude mouse are largely similar to those of the hairless mouse. 相似文献
49.
Hoffrogge R Beyer S Hübner R Mikkat S Mix E Scharf C Schmitz U Pauleweit S Berth M Zubrzycki IZ Christoph H Pahnke J Wolkenhauer O Uhrmacher A Völker U Rolfs A 《Proteomics》2007,7(1):33-46
Targeted differentiation of neural progenitor cells (NPCs) is a challenge for treatment of neurodegenerative diseases by cell replacement therapy and cell signalling manipulation. Here, we applied a proteome profiling approach to the rat striatal progenitor model cell line ST14A in order to elucidate cellular differentiation processes. Native cells and cells transfected with the glial cell line-derived neurotrophic factor (GDNF) gene were investigated at the proliferative state and at seven time points up to 72 h after induction of differentiation. 2-DE combined with MALDI-MS was used to create a reference 2-DE-map of 652 spots of which 164 were identified and assigned to 155 unique proteins. For identification of protein expression changes during cell differentiation, spot patterns of triplicate gels were matched to the 2-DE-map. Besides proteins that display expression changes in native cells, we also noted 43 protein-spots that were differentially regulated by GDNF overexpression in more than four time points of the experiment. The expression patterns of putative differentiation markers such as annexin 5 (ANXA5), glucosidase II beta subunit (GLU2B), phosphatidylethanolamine-binding protein 1 (PEBP1), myosin regulatory light chain 2-A (MLRA), NASCENT polypeptide-associated complex alpha (NACA), elongation factor 2 (EF2), peroxiredoxin-1 (PRDX1) and proliferating cell nuclear antigen (PCNA) were verified by Western blotting. The results reflect the large rearrangements of the proteome during the differentiation process of NPCs and their strong modification by neurotrophic factors like GDNF. 相似文献
50.