An inverse problem in neural processing

Any neural network aimed at the coding sensory events must contain computational properties which generally allow the organism to reconstruct the input signals with some degree of accuracy-else the association between stimulus and response would, at best, be uncertain. In this paper we investigate the problem of reconstructing external input signals to neural networks when the activity profiles of only some of its member cells are known. The evolution and activities of such cells are defined by an earlier formulation of one of us (Ouztöreli 1979) and, here, we restrict our application to local curcuits within the vertebrate retina. Solutions to this inverse coding problem are presented for specific network equations and examplified with 1, 3, and 5 neuron cases.This work was partially supported by the Natural Sciences and Engineering Research Council of Canada under Grant A-4345 to M.N.O. and grant A-4395 to T.M.C. through the University of Alberta     

Control mechanisms of a neural network

In this paper we consider some classical control theoretic properties of a nonlinear neural network proposed by Ouztöreli (1979) to represent the activities of constiuent neurones in terms of the input signals and coupling (associative) properties. By breaking the network into linear and nonlinear components we have been able to localize the nonlinearities in the individual neural response latencies through the system.This work was partially supported by the Natural Sciences and Engineering Research Council of Canada by Grant NSERC-A 4345 to M.N.O. and Grant NSERC-A 2568 to T.M.C. through the University of Alberta     

Interferon affects intracellular calmodulin levels

Interferon lowers calmodulin levels in two cell lines sensitive to its antiproliferative effect. Further, in synchronized cells, interferon strongly inhibits the increase in calmodulin observed when control cells enter the S phase, and concomitantly inhibits DNA synthesis. Calmodulin has been implicated in the control of cell proliferation and an increase in this protein seems to be necessary for the progression of cells into the S phase of the cell cycle. Therefore, the effect of interferon on calmodulin content might constitute part of the molecular mechanism by which interferon inhibits DNA synthesis.     

Microbial Production of Lysine and Threonine from Whey Permeate

Extracellular accumulation of lysine and threonine was investigated in modified whey permeate by using Brevibacterium lactofermentum ATCC 21086 and Escherichia coli ATCC 21151. Whey permeate was prepared from whey by membrane ultrafiltration, and lactose was hydrolyzed by treating permeate with HCl or β-galactosidase. The highest amount of lysine (3.3 g/liter) was produced from a mixture of acid-hydrolyzed whey permeate and yeast extract (0.2%). The highest amount of threonine (3.6 g/liter) was produced from a mixture of whey permeate, (NH₄)₂SO₄ (1.4%), yeast extract (0.1%), and Na₂CO₃ (0.3%).     

Restriction map of Tn7

Tn7, a transposon of 14 kb, encodes resistance to trimethoprim (Tp) and streptomycin (Sm). A cleavage site map of this transposon for twenty-two different restriction enzymes as determined by comparison of restriction enzyme cleavage patterns of the plasmids ColE1 and ColE1::Tn7 is presented. The precise localization of these sites was facilitated by the use of two deletion derivatives of ColE1::Tn7: pGB2 and ColE1::Tn7Δ6, and by the use of pOB14 and pOB15 which contain a part of Tn7 cloned into the plasmid pBR322. This map should aid in the study of the structural and genetic organization of this transposon.     

Recherches sur la conservation du virus de la densonucléose

Résumé Le virus de la densonucléose (VDN) conserve une partie de sa virulence en solution aqueuse entre 0°C et 30°C pendant deux mois. Son pouvoir infectieux se maintient à—10°C pendant deux mois mais est supprimé après dix jours de dessication. On peut done considérer ceParvovirus d’Insectes comme un virus relativement résistant aux températures que l’on rencontre ordinairement dans la nature et au laboratoire.

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Summary The persistence of DNV is described. This virus retains a part of its infectivity in aqueous solution between 0°C and 30°C. The log LD₅₀ initially 7,15 drops to 2 after two months. The virus keeps its infectivity at 10°C but it loses all its pathogenicity after 10 days in dry conditions.

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Ce travail a été réalisé en partie dans le cadre d’une convention I.N.R.A.-D.R.M.E.     

Absorbance-temperature profile of ribosomes from seeds of Pinus lambertiana

The absorbance (260 nm)-temperature profile of ribosomes from seeds of $\text{Pinus lambertiana}$, in the temperature range of about 25 – 60° was observed to be biphasic. When r-proteins in ribosomes were dansylated by 5-dimethylamino-1-naphthalenesulfonyl chloride dispersed on celite (180 molecules of 5-dimethylamino-1-naphthalenesulfonyl chloride per one ribosome particle), each transition midpoint was lowered by 2 – 3° and the sharpness of the transition of each phase was increased. The result of the present work suggests discrete cooperative transitions of the conformation of r-RNAs in ribosomes and its control by r-proteins.