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Sabine JM de Brouwer Henri?t van Middendorp Floris W Kraaimaat Timothy RDJ Radstake Irma Joosten A Rogier T Donders Agnes Eijsbouts Saskia Spillekom-van Koulil Piet LCM van Riel Andrea WM Evers 《Arthritis research & therapy》2013,15(6):R200
Introduction
Psychological stress may alter immune function by activating physiological stress pathways. Building on our previous study, in which we report that stress management training led to an altered self-reported and cortisol response to psychological stress in patients with rheumatoid arthritis (RA), we explored the effects of this stress management intervention on the immune response to a psychological stress task in patients with RA.Methods
In this study, 74 patients with RA, who were randomly assigned to either a control group or a group that received short stress management training, performed the Trier Social Stress Test (TSST) 1 week after the intervention and at a 9-week follow-up. Stress-induced changes in levels of key cytokines involved in stress and inflammatory processes (for example, interleukin (IL)-6 and IL-8) were assessed.Results
Basal and stress-induced cytokine levels were not significantly different in patients in the intervention and control groups one week after treatment, but stress-induced IL-8 levels were lower in patients in the intervention group than in the control group at the follow-up assessment.Conclusions
In line with our previous findings of lower stress-induced cortisol levels at the follow-up of stress management intervention, this is the first study to show that relatively short stress management training might also alter stress-induced IL-8 levels in patients with RA. These results might help to determine the role of immunological mediators in stress and disease.Trial registration
The Netherlands National Trial Register (NTR1193) 相似文献105.
Wallcraft J Amering M Freidin J Davar B Froggatt D Jafri H Javed A Katontoka S Raja S Rataemane S Steffen S Tyano S Underhill C Wahlberg H Warner R Herrman H 《World psychiatry》2011,10(3):229-236
WPA President M. Maj established the Task Force on Best Practice in Working with Service Users and Carers in 2008, chaired by H. Herrman. The Task Force had the remit to create recommendations for the international mental health community on how to develop successful partnership working. The work began with a review of literature on service user and carer involvement and partnership. This set out a range of considerations for good practice, including choice of appropriate terminology, clarifying the partnership process and identifying and reducing barriers to partnership working. Based on the literature review and on the shared knowledge in the Task Force, a set of ten recommendations for good practice was developed. These recommendations were the basis for a worldwide consultation of stakeholders with expertise as service users, families and carers, and the WPA Board and Council. The results showed a strong consensus across the international mental health community on the ten recommendations, with the strongest agreement coming from service users and carers. This general consensus gives a basis for Task Force plans to seek support for activities to promote shared work worldwide to identify best practice examples and create a resource to assist others to begin successful collaboration. 相似文献
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Gudrun Herrman Hannah Missfelder Katharina Spanel-Borowski 《Histochemistry and cell biology》1996,105(2):129-137
Epithelial cells of different phenotypes derived from bovine corpus luteum have been studied intensively in our laboratory. In this study, specific lectin binding was examined for cells of type 1 and 3, which were defined as endothelial cells. In order to confirm differences in their glycocalyx at the light microscopic level, five biotinylated lectins were applied to postconfluent cultures which had been fixed with buffered paraformaldehyde or glutaraldehyde. Cells were not permeabilized with any detergent. Lectin binding was localized with a streptavidin-peroxidase complex which was visualized with two different techniques. The DAB technique detected peroxidase histochemically, while the immunogold technique used an anti-peroxidase gold complex together with silver amplification. Neither cell type 1 nor cell type 3 bound a particular lectin selectively, yet each cell type expressed a particular lectin binding pattern. With the DAB technique, diverse lectin binding patterns were seen, probably indicating either outside binding, i.e., a diffuse pattern, a lateral-cell-side pattern and a microvillus-like pattern, or inside binding, i.e., a diffuse pattern, and a granule-like pattern. With the immunogold technique, only outside binding was observed. In addition, the patterns of single cilia or of single circles were detected, the latter roughly representing 3-m-sized binding sites for concanavalin A. When localizing them at the ultrastructural level, single circles corresponded with micron-sized discontinuities of the plasma membrane. Shedding vesicles were detected whose outer embrane was labelled with concanavalin A. Our results confirm the diversity of the two cell types under study. The inside lectin binding may be caused by way of transient plasma membrane openings and related to shedding of right-side out vesicles (ectocytosis). 相似文献
107.
Claudia A Sevillano Marcos S Lopes Barbara Harlizius Egiel HAT Hanenberg Egbert F Knol John WM Bastiaansen 《遗传、选种与进化》2015,47(1)
Background
Cryptorchidism and scrotal/inguinal hernia are the most frequent congenital defects in pigs. Identification of genomic regions that control these congenital defects is of great interest to breeding programs, both from an animal welfare point of view as well as for economic reasons. The aim of this genome-wide association study (GWAS) was to identify single nucleotide polymorphisms (SNPs) that are strongly associated with these congenital defects. Genotypes were available for 2570 Large White (LW) and 2272 Landrace (LR) pigs. Breeding values were estimated based on 1 359 765 purebred and crossbred male offspring, using a binary trait animal model. Estimated breeding values were deregressed (DEBV) and taken as the response variable in the GWAS.Results
Heritability estimates were equal to 0.26 ± 0.02 for cryptorchidism and to 0.31 ± 0.01 for scrotal/inguinal hernia. Seven and 31 distinct QTL regions were associated with cryptorchidism in the LW and LR datasets, respectively. The top SNP per region explained between 0.96% and 1.10% and between 0.48% and 2.77% of the total variance of cryptorchidism incidence in the LW and LR populations, respectively. Five distinct QTL regions associated with scrotal/inguinal hernia were detected in both LW and LR datasets. The top SNP per region explained between 1.22% and 1.60% and between 1.15% and 1.46% of the total variance of scrotal/inguinal hernia incidence in the LW and LR populations, respectively. For each trait, we identified one overlapping region between the LW and LR datasets, i.e. a region on SSC8 (Sus scrofa chromosome) between 65 and 73 Mb for cryptorchidism and a region on SSC13 between 34 and 37 Mb for scrotal/inguinal hernia.Conclusions
The use of DEBV in combination with a binary trait model was a powerful approach to detect regions associated with difficult traits such as cryptorchidism and scrotal/inguinal hernia that have a low incidence and for which affected animals are generally not available for genotyping. Several novel QTL regions were detected for cryptorchidism and scrotal/inguinal hernia, and for several previously known QTL regions, the confidence interval was narrowed down.Electronic supplementary material
The online version of this article (doi:10.1186/s12711-015-0096-6) contains supplementary material, which is available to authorized users. 相似文献108.
Jouvin-Marche E; Cuddihy A; Butler S; Hansen JN; Fitch WM; Rudikoff S 《Molecular biology and evolution》1988,5(5):500-511
The immunoglobulin kappa light-chain constant region gene (C kappa) has
been cloned and sequenced from five wild mouse species. Analysis of these
data has permitted an assessment of single-copy gene evolution during a
limited time period as defined by the genus Mus. Sequence conservation was
found to be as high (or higher) in the 5' and enhancer regions as in the
coding region. The pattern of substitutions throughout these genes suggests
that parallel evolution has occurred frequently and that substitutions at
replacement sites have not decreased significantly, owing to saturation
during this period of approximately 10 Myr. Phylogenetic relationships have
been determined among these wild species as well as among members of the
genus Rattus.
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