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351.
O'Kelley , Joseph C., and Walter R. Herndon . (U. Alabama, University.) Alkaline earth elements and zoospore release and development in Protosiphon botryoides . Amer. Jour. Bot. 48(9): 796–802. Illus. 1961.—Cells of Protosiphon botryoides Klebs from depleted nutrient medium containing Ca were washed and resuspended in fresh complete medium with Ca; or in media with a Sr, Ba or Na replacement, respectively, for Ca; or in an equivalent CaCl2 solution or deionized water. Zoospore release was observed in these media upon illumination following a 12-hr dark period. Free zoospores were less abundant in Sr-, Ba- and Na-replacement media than in the Ca medium. Zoospore production and release also were depressed in solutions of only CaCl2 and in deionized water. In the Sr and Ba media, zoospores were formed but not released from the parent cell, as a rule; some zoospores were released in mass within a gelatinous vesicle which did not liquefy and set the zoospores free; these zoospores lost motility and continued development in Sr, producing characteristic, spheroidal clusters of aplanospores. In the Na medium, protoplasmic cleavage preceding zoospore formation was severely inhibited. A study of the reversibility of Sr inhibition of the zoospore-release mechanism revealed evidence of reversion 12 hr after replacement of Sr by Ca. Walls of cells produced in Ca are rich in ruthenium red-positive materials, whereas cells produced under conditions of Sr replacement lack these materials. The significance of these findings in relation to the Ca requirement of other algal species is discussed. 相似文献
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Mutations in the mitochondrial transacylase tafazzin, Taz1p, in Saccharomyces cerevisiae cause Barth syndrome, a disease of defective cardiolipin remodeling. Taz1p is an interfacial membrane protein that localizes to both the outer and inner membranes, lining the intermembrane space. Pathogenic point mutations in Taz1p that alter import and membrane insertion result in accumulation of monolysocardiolipin. In this study, we used yeast as a model to investigate the biogenesis of Taz1p. We show that to achieve this unique topology in mitochondria, Taz1p follows a novel import pathway in which it crosses the outer membrane via the translocase of the outer membrane and then uses the Tim9p-Tim10p complex of the intermembrane space to insert into the mitochondrial outer membrane. Taz1p is then transported to membranes of an intermediate density to reach a location in the inner membrane. Moreover, a pathogenic mutation within the membrane anchor (V224R) alters Taz1p import so that it bypasses the Tim9p-Tim10p complex and interacts with the translocase of the inner membrane, TIM23, to reach the matrix. Critical targeting information for Taz1p resides in the membrane anchor and flanking sequences, which are often mutated in Barth syndrome patients. These studies suggest that altering the mitochondrial import pathway of Taz1p may be important in understanding the molecular basis of Barth syndrome. 相似文献
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Two ovariectomized female rhesus monkeys treated year-round with estradiol-filled capsules were used in hour-long behavioral tests with male rhesus monkeys both in and out of the normal breeding season. The study was designed primarily to test male hormonal responses to copulatory behavior and it was expected that behavior of the females would be essentially the same under both seasonal conditions. Several behaviors of the female, however, were found to fluctuate on a seasonal basis, namely (1) proximity to the male, (2) grooming of the male, (3) sexual presentations, and (4) threatening away (a form of sexual invitation). All of these behaviors, except proximity, were found to be positively correlated with the male partner's testosterone levels before and after the behavior test in the only test condition in which most males ejaculated. The preliminary suggestion is made that these females responded to some cue, either from the environment or from the males, that caused a change in their behavior between breeding and nonbreeding seasons despite the constant hormonal environment provided by the estradiol capsules. Since the same behaviors which were sensitive to seasonal effects were positively correlated with male testosterone levels, it is possible that the male's hormonal status affects affects female behavior. 相似文献
358.
Human clinical and psychophysical observations suggest that the taste
system is able to compensate for losses in peripheral nerve input, since
patients do not commonly report decrements in whole mouth taste following
chorda tympani nerve damage or anesthesia. Indeed, neurophysiological data
from the rat nucleus of the solitary tract (NST) suggests that a release of
inhibition (disinhibition) may occur centrally following chorda tympani
nerve anesthesia. Our purpose was to study this possibility further. We
recorded from 59 multi- and single- unit taste-responsive sites in the rat
NST before, during and after recovery from chorda tympani nerve anesthesia.
During anesthesia, average anterior tongue responses were eliminated but no
compensatory increases in palatal or posterior tongue responses were
observed. However, six individual sites displayed increased taste
responsiveness during anesthesia. The average increase was 32.9%.
Therefore, disinhibition of taste responses was observed, but infrequently
and to a small degree in the NST At a subset of sites, chorda
tympani-mediated responses decreased while greater superficial
petrosal-mediated responses remained the same during anesthesia. Since this
effect was accompanied by a decrease in spontaneous activity, we propose
that taste compensation may result in part by a change in signal-to-noise
ratio at a subset of sites.
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