Second‐generation decline: Scenarios for the economic and ethnic futures of the post‐1965 American immigrants

‘Second‐generation decline’ questions the current American faith in the myth of nearly automatic immigrant success. In discussing economic scenarios, positive and negative, for the future of the children of the post‐1965 immigrants, the possibility is proposed that a significant number of the children of poor immigrants, especially dark‐skinned ones, might not obtain jobs in the mainstream economy. Neither will they be willing ‐ or even able ‐ to take low‐wage, long‐hour ‘immigrant’ jobs, as their parents did. As a result, they (and young males among them particularly) may join blacks and Hispanics among those already excluded, apparently permanently, from the mainstream economy. The article also deals with the relations between ethnicity and economic conditions in the USA and with the continued relevance of the assimilation and acculturation processes described by ‘straight‐line theory’. This issue, as well as most others discussed, may also be salient for European countries experiencing immigration, especially those countries with troubled economies.     

Studies on the Assembly Characteristics of Large Subunit Ribosomal Proteins in S. cerevisae

During the assembly process of ribosomal subunits, their structural components, the ribosomal RNAs (rRNAs) and the ribosomal proteins (r-proteins) have to join together in a highly dynamic and defined manner to enable the efficient formation of functional ribosomes. In this work, the assembly of large ribosomal subunit (LSU) r-proteins from the eukaryote S. cerevisiae was systematically investigated. Groups of LSU r-proteins with specific assembly characteristics were detected by comparing the protein composition of affinity purified early, middle, late or mature LSU (precursor) particles by semi-quantitative mass spectrometry. The impact of yeast LSU r-proteins rpL25, rpL2, rpL43, and rpL21 on the composition of intermediate to late nuclear LSU precursors was analyzed in more detail. Effects of these proteins on the assembly states of other r-proteins and on the transient LSU precursor association of several ribosome biogenesis factors, including Nog2, Rsa4 and Nop53, are discussed.     

Effective Part-Task Training as Evidence of Distinct Adaptive Processes with Different Time Scales

For some types of visuo-motor transformations like large visuo-motor rotations or the complex transformation of a sliding first-order lever, distinct adaptive processes have been hypothesized that produce a rapid, discrete approximation of the transformation and a slow, graded fine tuning, respectively. Here we investigate whether part-task training of only the second of these processes, namely the fine tuning, transfers to the subsequent performance in a condition with the full transformation of the sliding first-order lever. Therefore, we compared performance of three groups with different practice conditions during transfer to the full transformation. While two groups only practiced the fine tuning without the right-left inversion of the lever prior to transfer, a third group practiced the full lever transformation. Our results show a positive, but less than perfect transfer of the isolated practice of the fine tuning on performance with the full transformation. For the fine tuning itself, transfer was not reliably different from being perfect. The observation that the fine tuning can be acquired separately and added to the later adaptation to the left-right inversion of the lever supports the notion that these slow and fast processes progress rather independently. The additional finding that the preceding acquisition of the fine tuning also facilitates the subsequent rapid process could be due to generalized learning-to-learn or to a more precise assignment of movement errors to the process from which they originate.     

Biochemical and Molecular Responses to Loss of Renal Mass: Atpase and Cyclic Nucleotides: Evidence for Altered Cyclic Nucleotide Metabolism During Compensatory Renal Hypertrophy and Neonatal Kidney Growth

In adult male Sprague-Dawley rats contralateral nephrectomy was followed by an initial fall of the concentration of cGMP in renal cortical tissue followed by a rise to a peak level of 300 percent of the initial concentration within two hours. cGMP concentration in the remaining renal cortex remained at about 300 percent of the initial value during the subsequent 72 hours and slowly declined to 150-200 percent in the following two weeks. The changes in cGMP concentration were due to exactly parallel changes in the soluble fraction of renal cortical guanylate cyclase activity, while cGMP-phosphodiesterase activity remained unchanged. cAMP concentration after contralateral nephrectomy fell significantly by about 25 percent within two hours and remained below baseline level for up to eight hours. In the kidneys of newborn rats the concentration of cAMP was approximately one-half that found in adult kidneys: it slightly fell between the fourth and the seventh day after birth and subsequently continuously rose to reach adult values approximately two weeks after birth. The concentration of cGMP was significantly greater four days after birth than in adult rats, further rose between the fourth and the seventh day after birth and subsequently gradually declined to adult levels. The increased cGMP concentration appears to be due to an increase of guanylate cyclase activity in total kidney homogenates which, in turn, was mainly due to an increase of the particulate (membrane-bound) fraction of the enzyme. cGMP-phosphodiesterase activity, however, was also increased in respect to adult levels, one or three weeks after birth. Renal growth from the seventh day after birth to adulthood is accompanied by a continuous increase of the ratio cAMP/cGMP. Removal of one kidney four to seven days after birth resulted in a slower increase of this ratio. The data suggest that cGMP may trigger renal growth and that increases of cGMP concentration in the kidneys are the result of a primary increase in the activity of guanylate cyclase.     

Professor Dr. Geoffrey Burnstock (1929–2020)

Purinergic Signalling -     

Relationships of reproductive performance indicators in black rhinoceros (Diceros bicornis michaeli) with plant available moisture,plant available nutrients and woody cover

Plant available moisture and plant available nutrients in soils influence forage quality and availability and subsequently affect reproductive performance in herbivores. However, the relationship of soil moisture, soil nutrients and woody forage with reproductive performance indicators is not well understood in mega‐browsers yet these three are important in selecting suitable areas for conservation of mega‐browsers. Here, the eastern black rhinoceros (Diceros bicornis michaeli), a mega‐browser, was studied in seven geographically distinct populations in Kenya to understand the relationships between its reproductive performance indicators and plant available moisture, plant available nutrients and woody cover. Reproductive parameters showed a complex relationship with plant available moisture and plant available nutrients. We found an increase in the predicted yearly percentage of females calving as plant available nutrients decreased in areas of high levels of plant available moisture but no relationship with plant available nutrients in areas of low plant available moisture. Age at first calving was earlier, inter‐calving interval was longer and yearly percentage of females calving was higher at higher woody cover. Woody plant cover contributes positively to black rhino reproduction performance indicators, whereas plant available moisture and plant available nutrients add to the selection of conservation areas, in more subtle ways.