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71.
JOSÉ ANTONIO FERNÁNDEZ PRIETO CARLOS AGUIAR EDUARDO DIAS MARIA ISABEL GUTIÉRREZ VILLARÍAS 《Botanical journal of the Linnean Society. Linnean Society of London》2008,157(3):493-499
The majority of authors consider Festuca jubata Lowe as an endemic species common to Madeira and the Azores. Saint-Yves proposed that F. jubata was an Azorean endemic and described a geovicarious taxon in Madeira: F. filiformis C. Sm. ex Link in Buch ssp. mandonii St.-Yves. We undertook a complete bibliographical revision of the taxonomy, nomenclature, and chorology of F. jubata s.l. , and contrasted it with morphological and anatomical studies performed on samples from the Azores and Madeira. Azorean plants usually identified as F. jubata had a character combination distinct from that of those with a Madeiran provenance. Saint-Yves' proposal of two independent taxa was correct, but he erroneously considered F. jubata as an Azorean endemic because the name F. jubata was based on Madeiran plants. Consequently, F. jubata auct. pl. from the Azores belongs to a new species. © 2008 The Linnean Society of London, Botanical Journal of the Linnean Society , 2008, 157 , 493–499. 相似文献
72.
The cancer stem cell hypothesis posits that tumor growth is driven by a rare subpopulation of cells, designated cancer stem cells (CSC). Studies supporting this theory are based in large part on xenotransplantation experiments wherein human cancer cells are grown in immunocompromised mice and only CSC, often constituting less than 1% of the malignancy, generate tumors. Herein, we show that all colonies derived from randomly chosen single cells in mouse lung and breast cancer cell lines form tumors following allografting histocompatible mice. Our study suggests that the majority of malignant cells rather than CSC can sustain tumors and that the cancer stem cell theory must be reevaluated. 相似文献
73.
Sengupta A Carlson BA Weaver JA Novoselov SV Fomenko DE Gladyshev VN Hatfield DL 《The Biochemical journal》2008,413(1):151-161
Sec (selenocysteine) is biosynthesized on its tRNA and incorporated into selenium-containing proteins (selenoproteins) as the 21st amino acid residue. Selenoprotein synthesis is dependent on Sec tRNA and the expression of this class of proteins can be modulated by altering Sec tRNA expression. The gene encoding Sec tRNA (Trsp) is a single-copy gene and its targeted removal in liver demonstrated that selenoproteins are essential for proper function wherein their absence leads to necrosis and hepatocellular degeneration. In the present study, we found that the complete loss of selenoproteins in liver was compensated for by an enhanced expression of several phase II response genes and their corresponding gene products. The replacement of selenoprotein synthesis in mice carrying mutant Trsp transgenes, wherein housekeeping, but not stress-related selenoproteins are expressed, led to normal expression of phase II response genes. Thus the present study provides evidence for a functional link between housekeeping selenoproteins and phase II enzymes. 相似文献
74.
Shrimali RK Irons RD Carlson BA Sano Y Gladyshev VN Park JM Hatfield DL 《The Journal of biological chemistry》2008,283(29):20181-20185
Selenium is an essential dietary element with antioxidant roles in immune regulation, but there is little understanding of how this element acts at the molecular level in host defense and inflammatory disease. Selenium is incorporated into the amino acid selenocysteine (Sec), which in turn is inserted into selenoproteins in a manner dependent on Sec tRNA([Ser]Sec). To investigate the molecular mechanism that links selenium to T cell immunity, we generated mice with selenoprotein-less T cells by cell type-specific ablation of the Sec tRNA([Ser]Sec) gene (trsp). Herein, we show that these mutant mice exhibit decreased pools of mature T cells and a defect in T cell-dependent antibody responses. We also demonstrate that selenoprotein deficiency leads to oxidant hyperproduction in T cells and thereby suppresses T cell proliferation in response to T cell receptor stimulation. These findings offer novel insights into immune function of selenium and physiological antioxidants. 相似文献
75.
Sengupta A Carlson BA Hoffmann VJ Gladyshev VN Hatfield DL 《Biochemical and biophysical research communications》2008,365(3):446-452
Selenium is incorporated into proteins as selenocysteine (Sec), which is dependent on its specific tRNA, designated tRNA[Ser]Sec. Targeted removal of the tRNA[Ser]Sec gene (Trsp) in mouse hepatocytes previously demonstrated the importance of selenoproteins in liver function. Herein, analysis of plasma proteins in this Trsp knockout mouse revealed increases in apolipoprotein E (ApoE) that was accompanied by elevated plasma cholesterol levels. The expression of genes involved in cholesterol biosynthesis, metabolism and transport were also altered in knockout mice. Additionally, in two transgenic Trsp mutant mouse lines (wherein only housekeeping selenoprotein synthesis was restored), the expression of ApoE, as well as genes involved in cholesterol biosynthesis, metabolism and transport were similar to those observed in wild type mice. These data correlate with reports that selenium deficiency results in increased levels of ApoE, indicating for the first time that housekeeping selenoproteins have a role in regulating lipoprotein biosynthesis and metabolism. 相似文献
76.
DESCRIPTION OF THE SENSORY CHARACTERISTICS OF SPANISH UNIFLORAL HONEYS BY FREE CHOICE PROFILING 总被引:1,自引:0,他引:1
MIGUEL ANGEL GONZÁLEZ-VIÑAS AIDA MOYA MARIA DOLORES CABEZUDO 《Journal of sensory studies》2003,18(2):103-113
Different Spanish unifloral honeys (eucalyptus, sunflower, rosemary, thyme, lavender, citrus, anise, quercus, and lemon blossom) and one multifloral honey were studied by Free-Choice Profiling (FCP) analysis. Generalized Procrustes Analysis (GPA) applied to the FCP data allowed discrimination between samples and provided information on the attributes responsible for the differences observed. The honeys had significantly different sensory characteristics. Textural attributes were the predominant factor in discriminating between samples, and appearance (color included) was also correlated with GPA dimensions to a lesser extent. 相似文献
77.
Reproductive ecology of Rhododendron ponticum (Ericaceae) in relict Mediterranean populations 总被引:2,自引:0,他引:2
JOSÉ A. MEJÍAS JUAN ARROYO FERNANDO OJEDA† 《Botanical journal of the Linnean Society. Linnean Society of London》2002,140(3):297-311
In the southern Iberian Peninsula, Rhododendron ponticum occurs in restricted and vulnerable populations as a Tertiary relict. Population structure and the main phases of the reproductive process were examined in order to shed light on recruitment patterns and limitations. Rhododendron ponticum flowers are self-compatible and attract a diverse array of insects, which are responsible for a considerable number of seeds set in the populations. Nevertheless, only adults form populations, whilst seedlings are scarce and saplings virtually absent (only two juveniles out of 2489 adults sampled). Non-specialized vegetative multiplication by layering was observed. Recruitment failure seems to depend on the scarcity of safe microsites, which are free from drought, for seedling establishment. The observations contrast with R. ponticum 's reputation as an aggressive invader in temperate Atlantic areas. It is proposed that the species shows a variable balance between sexual reproduction and vegetative multiplication depending on environmental conditions. At present, only the latter seems to be prevailing in relict populations in the Iberian Peninsula. This flexible reproductive strategy is also discussed as a mechanism allowing persistence during geological climatic oscillations. © The Linnean Society of London, Botanical Journal of the Linnean Society , 2002, 140 , 297–311. 相似文献
78.
Kim E. Berlin Thane K. Pratt John C. Simon James R. Kowalsky Jeff S. Hatfield 《Biotropica》2000,32(1):90-99
We recorded the times of flowering, fruiting, and leafing for ten native canopy and subcanopy trees and shrubs (monthly from December 1994 through December 1997) in a montane cloud forest with relatively aseasonal rainfall on the island of Maui, Hawaii. These species represented the great majority of individual woody plants at the site. Flowers and fruits were available in the community year–round; however, all species exhibited annual patterns of flowering, and four species showed annual patterns of fruiting while the rest fruited in supra–annual patterns. Many species had protracted flowering or fruiting peaks, and some bore small numbers of flowers or fruit year‐round. Most species flowered in a monthly peak mainly between May and August, corresponding to the period of greatest solar irradiance and marginally higher temperatures. Fruit ripening followed at varying intervals. In contrast, the heaviest flowering occurred between November and March, resulting from bloom of the dominant tree, Metrosideros polymorpha. At the highest elevations, Metrosideros flowering was heaviest during September, but peak flowering of lower elevation trees occurred in late fall and winter. Two forms of this species differed in their temporal and spatial patterns of flowering. For M. polymorpha var. polymorpha and var. incana, bloom peaked annually between November and January; however, for M. polymorpha var. glaberrima, flowering peaked from April through July, with an earlier secondary peak in January. 相似文献
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