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131.
In certain planarian species that are able to switch between asexual and sexual reproduction, determining whether a sexual has the ability to switch to the asexual state is problematic, which renders the definition of sexuals controversial. We experimentally show the existence of two sexual races, acquired and innate, in the planarian Dugesia ryukyuensis. Acquired sexuals used in this study were experimentally switched from asexuals. Inbreeding of acquired sexuals produced both innate sexuals and asexuals, but inbreeding of innate sexuals produced innate sexuals only and no asexuals. Acquired sexuals, but not innate sexuals, were forced to become asexuals by ablation and regeneration (asexual induction). This suggests that acquired sexuals somehow retain asexual potential, while innate sexuals do not. We also found that acquired sexuals have the potential to develop hyperplastic and supernumerary ovaries, while innate sexuals do not. In this regard, acquired sexuals were more prolific than innate sexuals. The differences between acquired and innate sexuals will provide a structure for examining the mechanism underlying asexual and sexual reproduction in planarians. 相似文献
132.
Recently, we reported that intracerebroventricular (i.c.v.) injection of l-alanine attenuated the stress response under an acute stressful condition in chicks. However, no information of l-alanine was available for the influence on energy expenditure and changes in the posture under stressful conditions. The
purpose of the present study was to clarify whether central l-alanine affects heat production (HP) of neonatal chicks, and whether HP is correlated with the behavior after isolation-induced
stress. The i.c.v. injection of l-alanine (0.8 μmol) decreased oxygen consumption, carbon dioxide production and HP shortly after injection. Central l-alanine reduced the posture for active wakefulness, but increased the posture for sitting motionless with head drooped (sleeping
posture). The present study demonstrates that central l-alanine decreases energy expenditure and causes a hypnotic effect in chicks exposed to an acute stressful condition. 相似文献
133.
Comparison of the anorexigenic activity of CRF family peptides 总被引:1,自引:0,他引:1
Chie Tanaka Miharu Ushikai Haruka Amitani KaiChun Cheng Norifumi Nakamura 《Biochemical and biophysical research communications》2009,390(3):887-891
Corticotropin releasing factor (CRF) family peptides have an important role in the control of food intake. We investigated the effects of CRF family peptides on food intake and body weight gain in mice. Of the CRF family peptides, including CRF, urocortin1 (Ucn1), urocortin2 (Ucn2) and urocortin3 (Ucn3), peripherally administered Ucn1 was shown to have the most potent inhibitory effect on the food intake and body weight gain of both lean and high fat fed obese mice. In addition, repeated administration of Ucn1 lowered blood glucose and acylated ghrelin, and decreased the visceral fat weight of high fat fed obese mice. 相似文献
134.
135.
Yukino Odaka Mana Nakano Tomoko Tanaka Tomoko Kaburagi Haruka Yoshino Natsuko Sato‐Mito Kazuto Sato 《Obesity (Silver Spring, Md.)》2010,18(9):1688-1694
Few reports show whether a high‐fat (HF) dietary environment in the fetal period affects immune function or the development of lifestyle‐related disease at maturity. We examined the influence of an HF dietary environment in the fetal period on postnatal metabolic and immune function. A total of 16 pregnant mice were given control (CON) diet and 16 were given HF diet in the gestational period, from mating to delivery. After delivery lactating mice were given either CON or HF diet, resulting in four groups. After weaning, the offspring mice were given the same diet that their mothers received during lactation. HF dietary intake in the postnatal period increased fat pad weights, serum glucose, and leptin levels. An HF diet in the fetal period resulted in fewer splenic lymphocytes, a thinner thymic cortex, and impaired antigen‐specific immune reactions. Furthermore, tumor necrosis factor (TNF)‐α production and serum triglyceride levels were elevated in the fetal HF group. In addition, the HF‐HF group showed a consistent decrease in ovalbumin (OVA)‐specific IgG and elevation of IgE, associated with advanced fatty changes in the liver. Results from this study suggest that HF environment during the fetal period induces epigenetic propensity toward obesity and immunological burden in part due to increased adipose tissue mass, significant reduction in the number of immune cells and decreased activities of immune cells. 相似文献
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138.
Toshiaki Oda Hiroaki Kanehisa Kentaro Chino Toshiyuki Kurihara Toshihiko Nagayoshi Tetsuo Fukunaga Yasuo Kawakami 《Journal of electromyography and kinesiology》2007,17(5):587-595
The present study investigated the differences between the human medial gastrocnemius (MG) and soleus (SOL) muscles in length changes of muscle fascicles and tendinous tissues during twitch contraction induced by an electrical nerve stimulus. Also, the time-course characteristics of twitch torque were related with changes in the length of muscle fascicles and tendinous tissues. No significant difference was observed between MG and SOL in contraction and half relaxation times of the changes in lengths and velocities of both muscle fascicles and tendinous tissues. The time-course of changes in twitch torque was nearly identical to that of the length of muscle fascicles and tendinous tissues. It was suggested that the behavior of MG and SOL during twitch contraction is practically similar in spite of their known physiological and architectural differences, and that the time-course of twitch torque is greatly influenced by the changes in the length of muscle fascicles and tendinous tissues. 相似文献
139.
Chen CS Matsuoka R Arai S Momiyama Y Murakami H Kuno SY Ishikawa K Nakada K Tawata M Hayashi J 《Journal of biochemistry》2004,135(2):237-243
To determine the pathogenicities of mutated mtDNAs in patients with respiration defects, the possible involvement of nuclear DNA mutations has to be excluded, since respiratory function is controlled by both nuclear DNA and mtDNA. This was achieved by showing that the mutated mtDNAs and respiration defects were co-transferred from patients to mtDNA-less human cells, and the resultant cybrid clones carrying mutated mtDNAs expressed respiration defects. To decide whether the cybrid clones expressed respiration defects, in this study the lowest limits of normal respiratory function were evaluated by transfer of mtDNAs from 54 normal subjects to mtDNA-less HeLa cells. The resultant cybrid clones showed that 71% respiratory function was the lowest limit of mtDNAs from normal subjects. On the other hand, cybrid clones carrying pathogenic mtDNAs from patients with mitochondrial diseases showed 0-64% respiratory function, suggesting that less than 71% respiratory function in cybrid clones should be a reliable indicator of whether the mutated mtDNAs of the patients were pathogenic. 相似文献
140.