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41.
42.
The role of C9 in complement-mediated killing of Neisseria 总被引:7,自引:0,他引:7
G R Harriman A F Esser E R Podack A C Wunderlich A I Braude T F Lint J G Curd 《Journal of immunology (Baltimore, Md. : 1950)》1981,127(6):2386-2390
During the routine examination of a healthy 31-yr-old woman, we found an incomplete deficiency of the 9th component of complement (C9). By hemolytic assay her serum C9 activity was 10 to 15% of normal. Limited family studies suggested that she inherited the deficiency as an autosomal codominant trait.She had no history of unusual or severe infections. When tested for bactericidal activity against serum-sensitive Neisseria gonorrhoeae and N. meningitidis, her serum reacted comparably to normal serum. Normal serum depleted immunochemically of C9 and sera from congenitally C9-deficient patients were also bactericidal against serum-sensitive Neisseria but required 120 min to kill the same numbers of gonococci that intact serum killed within 30 min. In the electron microscope, N. gonorrhoeae incubated with C9-depleted serum were fragmented but lacked the typical C lesions. Therefore, serum lacking C9 can kill serum-sensitive Neisseria, unlike sera deficient in the other terminal C components. 相似文献
43.
DNA sequence analysis of the C3H H-2Kk and H-2Dk loci. Evolutionary relationships to H-2 genes from four other mouse strains 总被引:9,自引:0,他引:9
S Watts J M Vogel W D Harriman T Itoh H J Stauss R S Goodenow 《Journal of immunology (Baltimore, Md. : 1950)》1987,139(11):3878-3885
We generated nucleotide sequences for H-2Kk and H-2Dk from the C3H mouse, as well as for a genomic clone of H-2Db, in order to conduct an evolutionary analysis of the H-2 genes from three haplotypes, k, d, and b. H-2Kk from both the C3H and AKR strains, H-2Kd, H-2Kb, H-2Dk, H-2Ld, H-2Dd, H-2Db, and H-2Dp DNA sequences were aligned, and the alignments used to construct phylogenetic trees inferring the evolutionary relationships among the nine genes by two independent methods. Both approaches yielded trees with similar topologies. In addition, the sequence alignments revealed patterns of nucleotide substitutions which implicate both point mutation and recombination in the divergence of the H-2 genes. Future considerations for evolutionary analysis of class I genes are discussed. 相似文献
44.
Victoria Reyes-Garcýa Beronda L. Montgomery Anil Kumar Goel Daniel F. Austin ConcepciÓn ObÓn Diego Rivera Rainer W. Bussmann Neil A. Harriman NEIL A. Harriman Neil A. Harriman Aswini Pai Patrick Van Damme Charles R. Clement Missouri Botanical Garden Richard Felger Daniel F. Austin Charles R. Clement Daniel F. Austin 《Economic botany》2006,60(4):389-399
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A study of 12 streams draining forested and non-forested catchments was made in an area of central Scotland where slow-weathering bedrock was predominantly quartzite, schists and slates. Sitka spruce (Picea sitchensis Carriere) was the most common tree species. Precipitation in the area had an annual mean pH in the range 4.3–4.5. Streams within the planted zone were always more acid than those outside and had higher concentrations of aluminium and manganese. With one exception, trout were absent from streams within long-established forests and planted salmon eggs (Salmo salar L.) died within a few weeks. A high proportion of such eggs survived in streams outside the forest. Siphlonurus lacustris Eaton was the only mayfly nymph found in the most acid streams in summer collections. In winter samples, mayfly nymphs, Heptagenia lateralis (Curtis) were found in only one forest stream but several species were present in the non-forested catchments. It is suggested that spruce forests can effectively collect acid pollutants which are subsequently washed out, thus accelerating the acidification of the soil. Streams therefore become increasingly acid as the neutralisation capacities of their catchments decrease. 相似文献
47.
Lars Behrendt Anthony WD Larkum Anders Norman Klaus Qvortrup Min Chen Peter Ralph S?ren J S?rensen Erik Trampe Michael Kühl 《The ISME journal》2011,5(6):1072-1076
Cyanobacteria in the genus Acaryochloris are the only known oxyphototrophs that have exchanged chlorophyll a (Chl a) with Chl d as their primary photopigment, facilitating oxygenic photosynthesis with near infrared (NIR) light. Yet their ecology and natural habitats are largely unknown. We used hyperspectral and variable chlorophyll fluorescence imaging, scanning electron microscopy, photopigment analysis and DNA sequencing to show that Acaryochloris-like cyanobacteria thrive underneath crustose coralline algae in a widespread endolithic habitat on coral reefs. This finding suggests an important role of Chl d-containing cyanobacteria in a range of hitherto unexplored endolithic habitats, where NIR light-driven oxygenic photosynthesis may be significant. 相似文献
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My Lien T. Nguyen My Lien T. Nguyen Janna Rose Charles R. Clement Mary Eubanks Derek Burch Christie Allan Neil A. Harriman Eric P. Burkhart Kristine Stewart Keith P. A. Schnars Alfred Slinkard Daniel F. Austin Kevin D. Janni Christie Allan Eric P. Burkhart D. Rivera C. Obón Neil A. Harriman Shivcharn S. Dhillion Daniel F. Austin 《Economic botany》2003,57(4):650-662
50.
Protection of the villus epithelial cells of the small intestine from rotavirus infection does not require immunoglobulin A 总被引:4,自引:0,他引:4
Immunoglobulin A (IgA) is the primary immune response induced in the intestine by rotavirus infection, but vaccination with virus-like particles induces predominantly IgG, not IgA. To definitively assess the role of IgA in protection from rotavirus infection, IgA knockout mice, which are devoid of serum and secretory IgA, were infected and then rechallenged with murine rotavirus at either 6 weeks or 10 months. Following primary rotavirus infection, IgA knockout mice cleared virus as effectively as IgA normal control mice. Rotavirus-infected IgA knockout mice produced no serum or fecal IgA but did have high levels of antirotavirus serum IgG and IgM and fecal IgG, whereas IgA normal control mice made both serum IgA and IgG and fecal IgA. Both IgA normal and IgA knockout mice were totally protected from rotavirus challenge at 42 days. Ten months following a primary infection, both IgA normal and knockout mice still had high levels of serum and fecal antirotavirus antibody and were totally protected from rotavirus challenge. To determine if compensatory mechanisms other than IgG were responsible for protection from rotavirus infection in IgA knockout mice, mice were depleted of CD4(+) T cells or CD8(+) T cells. No changes in the level of protection were seen in depleted mice. These data show that fecal or systemic IgA is not essential for protection from rotavirus infection and suggest that in the absence of IgA, IgG may play a significant role in protection from mucosal pathogens. 相似文献