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991.
992.
Sell TC Tsai YS Smoliga JM Myers JB Lephart SM 《Journal of strength and conditioning research / National Strength & Conditioning Association》2007,21(4):1166-1171
Despite the emergence of golf-specific training programs and training aids, relatively little research has been conducted examining the physical characteristics that are important to golf performance. We studied the strength, flexibility, and balance characteristics of golfers across 3 proficiency levels based on handicap index (HCP) (<0, 1-9, and 10-20) to determine the physical characteristics unique to highly proficient golfers. A total of 257 (age: 45.5 +/- 12.8 years, height: 180.6 +/- 6.5 cm, weight: 87.9 +/- 12.6 kg) healthy, male golfers participated in the study. Testing included an assessment of strength (torso, shoulder, and hip), flexibility (torso, shoulder, and hip), and single-leg balance. Golfers in the highest proficiency group (HCP < 0) had significantly (p < 0.05) greater hip strength, torso strength, shoulder strength, shoulder flexibility, hip flexibility, torso flexibility, and balance (eyes open) than golfers in the lowest proficiency group (HCP 10-20). The results of this study demonstrate that better golfers possess unique physical characteristics that are important to greater proficiency. These characteristics have also been demonstrated to be modifiable through golf-specific training programs. 相似文献
993.
Myer GD Ford KR Brent JL Divine JG Hewett TE 《Journal of strength and conditioning research / National Strength & Conditioning Association》2007,21(3):831-836
There is currently no consensus with regard to the most effective method to train for improved acceleration, or with regard to which kinematic variable provides the greatest opportunity for improvement in this important performance characteristic. The purpose of this study was to determine the effects of resistive ground-based speed training and incline treadmill speed training on speed-related kinematic measures and sprint start speed. The hypothesis tested was that incline treadmill training would improve sprint start time, while the ground-based resistive training would not. Corollary hypotheses were that treadmill training would increase stride frequency and ground-based training would not affect kinematics during the sprint start. Thirty-one high school female soccer players (15.7 +/- 0.5 years) were assigned to either treadmill (n = 17) or ground-based (n = 14) training groups and trained 2 times a week for 6 weeks. The treadmill group utilized incline speed training on a treadmill, while the ground-based group utilized partner band resistance ground-based techniques. Three-dimensional motion analysis was used (4.5 m mark) before and after training to quantify kinematics during the fastest of 3 recorded sprint starts (9.1 m). Both groups decreased average sprint start time from 1.75 +/- 0.12 to 1.68 +/- 0.08 seconds (p < 0.001). Training increased stride frequency (p = 0.030) but not stride length. After training, total vertical pelvic displacement and stride length predicted 62% of the variance in sprint start time for the resistive ground-based group, while stride length and stride frequency accounted for 67% prediction of the variance in sprint start time for the treadmill group. The results of this study indicate that both incline treadmill and resistive ground-based training are effective at improving sprint start speed, although they potentially do so through differing mechanisms. 相似文献
994.
Lipoprotein e (P4) of Haemophilus influenzae: role in heme utilization and pathogenesis 总被引:9,自引:0,他引:9
Morton DJ Smith A VanWagoner TM Seale TW Whitby PW Stull TL 《Microbes and infection / Institut Pasteur》2007,9(8):932-939
Lipoprotein e (P4) of Haemophilus influenzae is a phosphomonoesterase, encoded by the hel gene, that has been implicated in the acquisition of heme by this fastidious organism. However, lipoprotein e (P4) is also involved in the utilization of NAD and NMN. Some reports have concluded that the reported heme-related growth defect actually reflects a growth defect for NAD. In the current study, hel insertion mutants were constructed and a role for e (P4) in heme acquisition was demonstrated independent of its role in NAD or NMN acquisition. In addition, a rat model of infection demonstrated a role for e (P4) in the pathogenesis of invasive disease. 相似文献
995.
Little is known of the mechanisms that induce the dedifferentiation of a single somatic cell into a totipotent embryogenic cell that can either be regenerated or develop into an embryo and subsequently an entire plant. In this Opinion article, we examine the cellular, physiological and molecular similarities and differences between different plant stem cell types. We propose to extend the plant stem cell concept to include single embryogenic cells as a totipotent stem cell based on their capacity to regenerate or develop into an embryo under certain conditions. Our survey suggests that differences in chromatin structure might ensure that meristem-localized stem cells have supervised freedom and are pluripotent, and that embryogenic stem cells are unsupervised, autonomous and, hence, freely totipotent. 相似文献
996.
997.
Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line 总被引:4,自引:0,他引:4
Wang B Schneider SN Dragin N Girijashanker K Dalton TP He L Miller ML Stringer KF Soleimani M Richardson DD Nebert DW 《American journal of physiology. Cell physiology》2007,292(4):C1523-C1535
Resistance to cadmium (Cd)-induced testicular necrosis is an autosomal recessive trait defined as the Cdm locus. Using positional cloning, we previously identified the Slc39a8 (encoding an apical-surface ZIP8 transporter protein) as the gene most likely responsible for the phenotype. In situ hybridization revealed that endothelial cells of the testis vasculature express high ZIP8 levels in two sensitive inbred mouse strains and negligible amounts in two resistant strains. In the present study, we isolated a 168.7-kb bacterial artificial chromosome (BAC), carrying only the Slc39a8 gene, from a Cd-sensitive 129/SvJ BAC library and generated BAC-transgenic mice. The BTZIP8-3 line, having three copies of the 129/SvJ Slc39a8 gene inserted into the Cd-resistant C57BL/6J genome (having its normal two copies of the Slc39a8 gene), showed tissue-specific ZIP8 mRNA expression similar to wild-type mice, mainly in lung, testis, and kidney. The 2.5-fold greater expression paralleled the fact that the BTZIP8-3 line has five copies, whereas wild-type mice have two copies, of the Slc39a8 gene. The ZIP8 mRNA and protein localized especially to endothelial cells of the testis vasculature in BTZIP8-3 mice. Cd treatment reversed Cd resistance (seen in nontransgenic littermates) to Cd sensitivity in BTZIP8-3 mice; reversal of the testicular necrosis phenotype confirms that Slc39a8 is unequivocally the Cdm locus. ZIP8 also localized specifically to the apical surface of proximal tubule cells in the BTZIP8-3 kidney. Cd treatment caused acute renal failure and signs of proximal tubular damage in the BTZIP8-3 but not nontransgenic littermates. BTZIP8-3 mice should be a useful model for studying Cd-induced disease in kidney. kidney; testis; ZIP8; bacterial artificial chromosome 相似文献
998.
Dziva F Mahajan A Cameron P Currie C McKendrick IJ Wallis TS Smith DG Stevens MP 《FEMS microbiology letters》2007,271(2):258-264
Enterohaemorrhagic Escherichia coli (EHEC) comprise a group of zoonotic diarrhoeal pathogens of worldwide importance. Cattle are a key reservoir; however the molecular mechanisms that promote persistent colonization of the bovine intestines by EHEC are ill-defined. The large plasmid of EHEC O157:H7 encodes several putative virulence factors. Here, it is reported that the pO157-encoded Type V-secreted serine protease EspP influences the intestinal colonization of calves. To dissect the basis of attenuation, a bovine primary rectal epithelial cell line was developed. Adherence of E. coli O157:H7 to such cells was significantly impaired by espP mutation but restored upon addition of highly purified exogenous EspP. Data of this study add to the growing body of evidence that cytotoxins facilitate intestinal colonization by EHEC. 相似文献
999.
1000.
In many species, reproduction requires detecting, recognizing, and courting a potential mate. Progress through these stages is guided by cues involving a wide range of sensory systems. Here we explore the tasks of detection, recognition, and response in terms of the ultrasonic songs of male mice presented with odor cues contained in urine. We find that the quantity of singing, more so than specific features of the songs, varies depending upon the odor cue. For experienced male mice, responses to female odor cues depend only on the concentration of female cues and are independent of the presence of male cues. However, for naive mice, male cues appear to be synergistic for the response to female cues. We therefore find no direct behavioral evidence for a role of opponent neural processing, such as lateral inhibition, in distinguishing sex by olfactory cues. However, modeling demonstrates that lateral inhibition could be one possible mechanism to account for the switch from synergy to independence. 相似文献