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101.
Ferdinand Bohlmann Maniruddin Ahmed Harold Robinson Robert M. King 《Phytochemistry》1982,21(7):1675-1678
The investigation of the aerial parts of a variety of Enhydra fluctuans afforded in addition to 4-hydroxyfarnesyl acetate and fluctuadin five new melampolides elucidated by high field 1H NMR spectroscopy. The chemotaxonomic situation is discussed briefly. 相似文献
102.
The sterol diol fraction from the lipids of organ-pipe cactus, Stenocereus thurberi, was separated into five compounds: macdougallin, peniocerol, cyclostenol, stenocereol and thurberol. The last three compounds have not been described before. All compounds were characterized by physical and spectroscopic properties. 相似文献
103.
Ferdinand Bohlmann Naleen Borthakur Robert M. King Harold Robinson 《Phytochemistry》1982,21(7):1793-1794
Calea reticulata afforded in addition to known compounds two new sesquiterpenes. These were germacrane and eudesmane derivatives, identified as germacra-4(15),5,10(14)-trien-1-one and 6-epi-β-verbesinol coumarate, respectively. 相似文献
104.
Ferdinand Bohlmann Rajinder K. Gupta Robert M.^King Harold Robinson 《Phytochemistry》1982,21(10):2593-2595
Calea villosa afforded three new sesquiterpene lactones, two furanoheliangolides and an epoxy- germacranolide, as well as several known compounds. The structures were elucidated by spectroscopic methods. 相似文献
105.
Ferdinand Bohlmann Maniruddin Ahmed Jasmin Jakupovic Robert M. King Harold Robinson 《Phytochemistry》1982,21(3):691-694
An investigation of Brickellia diffusa afforded three new dehydronerolidol derivatives and five new labdane derivatives, all highly oxygenated. The structures were elucidated by spectroscopic methods and a few chemical transformations. The compounds isolated showed close relationships to those isolated from Brickellia sp. 相似文献
106.
Ferdinand Bohlmann Alfons Adler Jasmin Jakupovic Robert M. King Harold Robinson 《Phytochemistry》1982,21(6):1349-1355
The investigation of two Mikania species, both previously placed in the genus Kanimia, afforded in addition to known compounds several new germ 相似文献
107.
Ferdinand Bohlmann Nezhun Ates Jasmin Jakupovic Robert M. King Harold Robinson 《Phytochemistry》1982,21(11):2691-2697
Artemisia douglasiana afforded, in addition to known compounds, two new C14-acetylenes, five longipinene derivatives, three nerolidol derivatives, a lactone and a ketone with a new carbon skeleton and lavendulol-2-methylbutyrate. The structures were elucidated by spectroscopic methods and some chemical transformations. The configurations of several oxo longipinene-7, 9-di- and 7, 8, 9-triesters isolated previously were corrected. The biogenesis of the new lactones is discussed briefly. 相似文献
108.
Tetradecanoyl phorbol acetate stimulates latent collagenase production by cultured human endothelial cells 总被引:15,自引:0,他引:15
Angiogenesis is associated with the fragmentation of blood vessel basement membranes. Since collagen is a major constituent of basement membranes, cultured human endothelial cells derived from umbilical cord veins were assayed for their ability to produce collagenase. Unstimulated cultured human endothelial cells did not secrete detectable levels of active collagenase into the culture medium. However, if the post-culture medium was treated with trypsin or plasmin, low levels of collagenolytic activity were detected, indicating that endothelial cells secrete small amounts of latent collagenase. Addition of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) to the culture medium stimulated the secretion of collagenase by endothelial cells 5–30 fold. More than 90% of the collagenase was secreted in the latent form. Stimulation of collagenase production was detected at 10?9 M TPA and was maximal at 10?8 M TPA. An increase in the rate of collagenase production could be detected within 3 hr after the addition of TPA, and full induction occurred by 12 hr. Cycloheximide (3 μg/ml) or actinomycin D (0.1 μg/ml) inhibited both basal levels of collagenase production and the stimulation of collagenase production by TPA. Phorbol-12,13-didecanoate (PDD), a tumor-promoting analog of TPA, also stimulated collagenase production when administered at the same concentrations that were effective for TPA. However, 4-O-methyl TPA and 4-αPDD, two analogs of TPA which are not tumor promoters, did not stimulate collagenase production at concentrations up to 10?7 M. The collagenase produced by endothelial cells was a typical vertebrate collagenase as judged by the following criteria: it cleaved collagen into only two fragments which were three quarters and one quarter of the length of the intact molecule; it was inhibited by EDTA and human serum; it was not inhibited by inhibitors of serine, thiol or aspartate proteases. Thus TPA causes an increase in the production of latent collagenase by cultured human endothelial cells. 相似文献
109.
Harold P. Klein 《Journal of molecular evolution》1979,14(1-3):161-165
Summary Several ground-based investigations have been carried out since the Viking biology results were received from Mars. Many of these have resulted in reasonable simulations of the Martian data, using as analogues of Mars either strong oxidants, UV-treated materials, iron-containing clays, or iron salts. The ambiguity between the GCMS experiment, in which no organic compounds were found on Mars, and the Labeled Release experiment, in which added organics were decomposed, may well be accounted for by these simulations. 相似文献
110.
Natural H Currents Traverse Growing Roots and Root Hairs of Barley (Hordeum vulgare L.) 总被引:28,自引:15,他引:13
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With the aid of an extracellular vibrating electrode, natural electric fields were detected and measured in the medium near growing roots and root hairs of barley seedlings. An exploration of these fields indicates that both the root as a whole, as well as individual root hairs, drive large steady currents through themselves. Current consistently enters both the main elongation zone of the root as well as the growing tips of elongating root hairs; it leaves the surface of the root beneath the root hairs. These currents enter with a density of about 2 microamperes per square centimeter, leave with a density of about 0.5 to 1 microampere per square centimeter, and total about 30 nanoamperes. 相似文献