Small non-coding RNA profiling in breast cancer: plasma U6 snRNA,miR-451a and miR-548b-5p as novel diagnostic and prognostic biomarkers

Molecular Biology Reports - Breast cancer is a leading cause of cancer-related death in women. Most cases are invasive ductal carcinomas of no special type (NST breast carcinomas). In this...     

Fluoride-resistant acid phosphatase (FRAP) activity of nociceptive nerve terminals in the dental pulp

Nerve fibers in the dental pulp of the lower molar teeth of the rat exert fluoride resistant acid phosphatase (FRAP) activity. FRAP-positive axons establish a three-dimensional nerve plexus within the pulp; the individual axons are very fine (calibre less than 1 micrometer) and only their varicosities measure 1...2 micrometer in diameter. Electron microscopically, FRAP-positive amyelinate axons containing lysosomes are partly embedded in Schwann cells. Removal of the cervical superior ganglion does not induce any alteration of FRAP-positive axons, while destruction of the Gasserian ganglion results in Wallerian degeneration. No FRAP-positive nerve fibers were found in rat incisors. Since, in the rat, only molar teeth are equipped with nociceptive terminals while continuously growing incisors lack pain fibers, it is concluded that FRAP-positive varicose axons in the dental pulp represent nerve endings of trigeminal primary nociceptive neurons.