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991.
Mostafa Alam Shahryar Karami Meysam Mohammadikhah Ashkan Badkoobeh Mohsen Golkar Kamyar Abbasi Reza Sayyad Soufdoost Lotfollah Kamali Hakim Sahar Talebi Reza Abdollahi Namanloo Ahmed Hussain Artak Heboyan Hamid Tebyaniyan 《Cell biochemistry and function》2024,42(2):e3951
The use of photobiomodulation therapy (PBMT) may be used for treating trauma to the maxillofacial region. The effects of PBMT on maxillofacial injuries were discussed in this review article. The electronic databases Pubmed, Scopus, and Web of Science were thoroughly searched. This review included in vitro, in vivo, and clinical studies describing how PBMT can be used in maxillofacial tissue engineering and regenerative medicine. Some studies suggest that PBMT may offer a promising therapy for traumatic maxillofacial injuries because it can stimulate the differentiation and proliferation of various cells, including dental pulp cells and mesenchymal stem cells, enhancing bone regeneration and osseointegration. PBMT reduces pain and swelling after oral surgery and tooth extraction in human and animal models of maxillofacial injuries. Patients with temporomandibular disorders also benefit from PBMT in terms of reduced inflammation and symptoms. PBMT still has some limitations, such as the need for standardizing parameters. PBMT must also be evaluated further in randomized controlled trials in various maxillofacial injuries. As a result, PBMT offers a safe and noninvasive treatment option for patients suffering from traumatic maxillofacial injuries. PBMT still requires further research to establish its efficacy in clinical practice and determine the optimal parameters. 相似文献
992.
Madani H Rahimi Z Manavi-Shad M Mozafari H Akramipour R Vaisi-Raygani A Rezaei M Malek-Khosravi S Shakiba E Parsian A 《Molecular biology reports》2011,38(4):2573-2578
To determine the plasma lipid and lipoprotein profiles and their possible association with the type of β-thalassemia mutation
we studied 103 major β-thalassemia patients including 71 children and 32 young adults compared to 102 healthy subjects consisted
of 90 children and 12 young healthy adults. The plasma lipid and lipoprotein levels were measured by conventional methods.
Considering all of the patients the levels of total cholesterol (TC), LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C)
were significantly lower compared to controls. However, the level of TG was significantly higher in cases than controls. Comparing
thalassemic patients homozygous for a β0 type of mutation with those homozygous for a β+ type of mutation (IVSI.110 G:A) indicated that the levels of LDL-C, TC were significantly increased and TG concentration
tended to be higher in the latter patients. In conclusion, our study indicates that hemolytic stress results in hypocholesterolemia
in major β-thalassemia patients and the presence of more severe genotype in patients is correlated with more reduction in
TG, TC, and LDL-C levels. 相似文献
993.
Ji-Hoon Park Min-Hee Kim Edwin Sutanto Seok-Won Na Min-Jae Kim Joon Sup Yeom Myat Htut Nyunt Mohammed Mohieldien Abbas Elfaki Muzamil Mahdi Abdel Hamid Seok Ho Cha Sisay Getachew Alemu Kanlaya Sriprawat Nicholas M. Anstey Matthew J. Grigg Bridget E. Barber Timothy William Qi Gao Yaobao Liu Richard D. Pearson Ric N. Price Francois Nosten Sung-Il Yoon Joo Hwan No Eun-Taek Han Sarah Auburn Bruce Russell Jin-Hee Han 《PLoS neglected tropical diseases》2022,16(6)
Plasmodium vivax is the most widespread cause of human malaria. Recent reports of drug resistant vivax malaria and the challenge of eradicating the dormant liver forms increase the importance of vaccine development against this relapsing disease. P. vivax reticulocyte binding protein 1a (PvRBP1a) is a potential vaccine candidate, which is involved in red cell tropism, a crucial step in the merozoite invasion of host reticulocytes. As part of the initial evaluation of the PvRBP1a vaccine candidate, we investigated its genetic diversity and antigenicity using geographically diverse clinical isolates. We analysed pvrbp1a genetic polymorphisms using 202 vivax clinical isolates from six countries. Pvrbp1a was separated into six regions based on specific domain features, sequence conserved/polymorphic regions, and the reticulocyte binding like (RBL) domains. In the fragmented gene sequence analysis, PvRBP1a region II (RII) and RIII (head and tail structure homolog, 152–625 aa.) showed extensive polymorphism caused by random point mutations. The haplotype network of these polymorphic regions was classified into three clusters that converged to independent populations. Antigenicity screening was performed using recombinant proteins PvRBP1a-N (157–560 aa.) and PvRBP1a-C (606–962 aa.), which contained head and tail structure region and sequence conserved region, respectively. Sensitivity against PvRBP1a-N (46.7%) was higher than PvRBP1a-C (17.8%). PvRBP1a-N was reported as a reticulocyte binding domain and this study identified a linear epitope with moderate antigenicity, thus an attractive domain for merozoite invasion-blocking vaccine development. However, our study highlights that a global PvRBP1a-based vaccine design needs to overcome several difficulties due to three distinct genotypes and low antigenicity levels. 相似文献
994.
Deborah J. Bird Iman Hamid Lester Fox‐Rosales Blaire Van Valkenburgh 《Ecology and evolution》2020,10(14):6929-6953
It is widely accepted that obligate aquatic mammals, specifically toothed whales, rely relatively little on olfaction. There is less agreement about the importance of smell among aquatic mammals with residual ties to land, such as pinnipeds and sea otters. Field observations of marine carnivorans stress their keen use of smell while on land or pack ice. Yet, one dimension of olfactory ecology is often overlooked: while underwater, aquatic carnivorans forage “noseblind,” diving with nares closed, removed from airborne chemical cues. For this reason, we predicted marine carnivorans would have reduced olfactory anatomy relative to closely related terrestrial carnivorans. Moreover, because species that dive deeper and longer forage farther removed from surface scent cues, we predicted further reductions in their olfactory anatomy. To test these hypotheses, we looked to the cribriform plate (CP), a perforated bone in the posterior nasal chamber of mammals that serves as the only passageway for olfactory nerves crossing from the periphery to the olfactory bulb and thus covaries in size with relative olfactory innervation. Using CT scans and digital quantification, we compared CP morphology across Arctoidea, a clade at the interface of terrestrial and aquatic ecologies. We found that aquatic carnivoran species from two lineages that independently reinvaded marine environments (Pinnipedia and Mustelidae), have significantly reduced relative CP than terrestrial species. Furthermore, within these aquatic lineages, diving depth and duration were strongly correlated with CP loss, and the most extreme divers, elephant seals, displayed the greatest reductions. These observations suggest that CP reduction in carnivorans is an adaptive response to shifting selection pressures during secondary invasion of marine environments, particularly to foraging at great depths. Because the CP is fairly well preserved in the fossil record, using methods presented here to quantify CP morphology in extinct species could further clarify evolutionary patterns of olfactory loss across aquatic mammal lineages that have independently committed to life in water. 相似文献
995.
Ajazul Hamid Wani 《Journal of molecular biology》2009,387(2):348-15
Kinetic and equilibrium studies of the folding and unfolding of the SH3 domain of the PI3 kinase, have been used to identify a folding intermediate that forms after the rate-limiting step on the folding pathway. Folding and unfolding, in urea as well as in guanidine hydrochloride (GdnHCl), were studied by monitoring changes in the intrinsic fluorescence or in the far-UV circular dichroism (CD) of the protein. The two probes yield non-coincident equilibrium transitions for unfolding in urea, indicating that an intermediate, I, exists in equilibrium with native (N) and unfolded (U) protein, during unfolding. Hence, the equilibrium unfolding data were analyzed according to a three-state N ↔ I ↔ U mechanism. An intermediate is observed also in kinetic unfolding studies, and its presence leads to the unfolding reaction in urea as well as in GdnHCl, occurring in two steps. The fast step is complete within the initial 11 ms of unfolding and manifests itself in a burst phase change in fluorescence. At high concentrations of GdnHCl, the entire change in fluorescence during unfolding occurs during the 11 ms burst phase. CD measurements indicate, however, that I retains N-like secondary structure. An analysis of the kinetic and thermodynamic data, according to a minimal three-state N ↔ I ↔ U mechanism, positions I after the rate-limiting transition state, TS1, of folding, on the reaction coordinate of folding in GdnHCl. Hence, I is not revealed when folding is commenced from U, regardless of the nature of the probe used to follow the folding reaction. Interrupted unfolding experiments, in which the protein is unfolded transiently in GdnHCl for various lengths of time before being refolded, showed that I refolds to N much faster than does U, confirms the analysis of the direct folding and unfolding experiments, that I is formed after the rate-limiting step of refolding in GdnHCl. 相似文献
996.
Gregory Cristofari Mohamed Znini Lhou Majidi Hamid Mazouz Pierre Tomi Jean Costa Julien Paolini 《化学与生物多样性》2012,9(4):727-738
Asteriscus graveolens is an endemic medicinal plant mainly distributed in south‐western Algeria and south‐eastern Morocco. The essential oils of leaves, stems, and flowers of A. graveolens had been studied by GC, GC/MS, and 13C‐NMR. The spectral data of two nerolidol derivatives, 6‐oxo‐ and 6‐hydroxycyclonerolidol, were reassigned by 1D‐ and 2D‐NMR spectroscopy. These compounds can be considered as chemical markers of this genus. The structure of a monoterpenic diester with a chrysanthenane skeleton, i.e., cis‐8‐acetoxychrysanthenyl acetate, was determined for the first time on the basis of GC/MS, and 1D‐ and 2D‐NMR. The stem and leaf oils were characterized by high content of oxygenated sesquiterpenes with 6‐oxo‐ and 6‐hydroxycyclonerolidol as major components, and the flower essential oils were dominated by the new monoterpenic compound cis‐8‐acetoxychrysanthenyl acetate. 相似文献
997.
Adrian Wai-Hing Cheung John Brinkman Fariborz Firooznia Alexander Flohr Joseph Grimsby Mary Lou Gubler Kevin Guertin Rachid Hamid Nicholas Marcopulos Roger D. Norcross Lida Qi Gwendolyn Ramsey Jenny Tan Yang Wen Ramakanth Sarabu 《Bioorganic & medicinal chemistry letters》2010,20(14):4140-4146
7-N-Acetamide-4-methoxy-2-aminobenzothiazole 4-fluorobenzamide (compound 1) was chosen as a drug-like and non-xanthine based starting point for the discovery of A2B receptor antagonists because of its slight selectivity against A1 and A2A receptors and modest A2B potency. SAR exploration of compound 1 described herein included modifications to the 7-N-acetamide group, substitution of the 4-methoxy group by halogens as well as replacement of the p-flouro-benzamide side chain. This work culminated in the identification of compound 37 with excellent A2B potency, modest selectivity versus A2A and A1 receptors, and good rodent PK properties. 相似文献
998.
Khodayar Gholivand Hamid Reza Mahzouni Mehrdad Pourayoubi Shadi Amiri 《Inorganica chimica acta》2010,363(10):2318-4308
Monodentate and bidentate ligands PhNHP(O)(NC4H8O)2 (1) and PhC(O)NHP(O)(NH(tert-C4H9))2 (2) were used to prepare new 7, 9 and 10-coordinated lanthanum(III) complexes; La(1)2Cl3(H2O)2 (3), La(1)2(NO3)3H2O.La(1)2(NO3)3CH3CN (4) and La(2)2(NO3)3 (5), respectively. Crystallization of compound 2 in CH3OH:CH3CN leads to one conformer in contrast to the crystallization result from CHCl3:n-C7H16 (two conformers). Compound 4 contains two independent nine-coordinated La(III) complexes that are different in the solvated molecules (H2O and CH3CN). Some structural and electronic perturbations in coordinated ligand were occurred upon complexation, that are confirmed by increase of 2JPH, 3JPH and 6JPH coupling constants from the free ligand 1 to complexes 3 and 4. The steric repulsions in the first coordination sphere of La3+ ion, metal-ligand (M-L) binding strength and PO stretching frequency are very influenced by changing the counter ion from Cl− to . Comparing the X-ray crystallography data of free ligand 2 with bis-chelated complex 5, it is found that the phosphoryl group is more reactive than carbonyl counterpart. A blue shift of the ν(N-H) vibration is observed in line with the weakening of the hydrogen bond from N-H···OPhosphoryl in 1 to N-H···Cl in 3. Three dimensional butterfly-shape structures are seen in the unit cell of complex 3, which are produced by OWater-H···OMorpholine hydrogen bonds. 相似文献
999.
Mohiddin F. A. Majid Rukhsanah Bhat Arif Hussain Dar M. S. Shikari Asif B. Sofi Najeebur Rehman Nabi Sajad un Hamid Aflaq Ahanger M. Ashraf Bhat F. A. Hussain Ashaq Bhat N. A. 《Molecular biology reports》2021,48(4):3173-3184
Molecular Biology Reports - Bakanae is the emerging disease threating the rice cultivation globally. Yield reduction of 4–70% is recorded in different parts of the world. A total of 119... 相似文献
1000.