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Hamid Muhammed H 《International journal of neural systems》2002,12(6):425-434
A novel algorithm for unsupervised fuzzy clustering is introduced. The algorithm uses a so-called Weighted Fixed Neural Network (WFNN) to store important and useful information about the topological relations in a given data set. The algorithm produces a weighted connected net, of weighted nodes connected by weighted edges, which reflects and preserves the topology of the input data set. The weights of the nodes and the edges in the resulting net are proportional to the local densities of data samples in input space. The connectedness of the net can be changed, and the higher the connectedness of the net is chosen, the fuzzier the system becomes. The new algorithm is computationally efficient when compared to other existing methods for clustering multi-dimensional data, such as color images. 相似文献
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Hamed R. Goodarzi Ali Abbasi Mojtaba Saffari Mohammad B. Tabei Mohammad R. Noori Daloii 《Molecular biology reports》2010,37(6):2959-2965
Male Pattern Baldness (MPB) or androgenetic alopecia is a common form of hair loss with androgens and genetics having etiological
significance. Androgens are thought to pathophysiologically power on cascades of chronically dramatic alterations in genetically
susceptible scalp dermal papillas, specialized cells in hair follicles in which androgens react, and finally resulting in
a patterned alopecia. However, the exact mechanisms through which androgens, positive regulators of growth and anabolism in
most body sites, paradoxically exert their effects on balding hair follicles, are not yet known. The role of microRNAs, a
recently discovered class of non-coding RNAs, with a wide range of regulatory functions, has been documented in hair follicle
formation and their deregulation in cancer of prostate, a target organ of androgens has also been delineated. Yet, there is a lack of knowledge in agreement with microRNAs’ contribution in pathophysiology of MPB. To investigate the
role of microRNAs in pathogenesis of MPB, we selected seven microRNAs, predicted bioinformatically on a reverse engineering
basis, from previously published microarray gene expression data and analyzed their expression in balding relative to non-balding
dermal papillas. We found for the first time upregulation of four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that
could participate in pathogenesis of MPB. Regarding microRNAs’ therapeutic potential and accessibility of hair follicles for
gene therapy, these microRNAs can be considered as good candidates for a new revolutionized generation of treatments. 相似文献
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Ammar Shaker Hamed Hasan Tra Thi Huong Dinh Hoai Thu Le Saori Mizuno-Iijima Yoko Daitoku Miyuki Ishida Yoko Tanimoto Kanako Kato Atsushi Yoshiki Kazuya Murata Seiya Mizuno Fumihiro Sugiyama 《Experimental Animals》2021,70(1):22
Two members of the CDK5 and ABL enzyme substrate (CABLES) family, CABLES1 and CABLES2, share a highly homologous C-terminus. They interact and associate with cyclin-dependent kinase 3 (CDK3), CDK5, and c-ABL. CABLES1 mediates tumor suppression, regulates cell proliferation, and prevents protein degradation. Although Cables2 is ubiquitously expressed in adult mouse tissues at RNA level, the role of CABLES2 in vivo remains unknown. Here, we generated bicistronic Cables2 knock-in reporter mice that expressed CABLES2 tagged with 3×FLAG and 2A-mediated fluorescent reporter tdTomato. Cables2-3×FLAG-2A-tdTomato (Cables2Tom) mice confirmed the expression of Cables2 in various mouse tissues. Interestingly, high intensity of tdTomato fluorescence was observed in the brain, testis and ovary, especially in the corpus luteum. Furthermore, immunoprecipitation analysis using the brain and testis in Cables2Tom/Tom revealed interaction of CABLES2 with CDK5. Collectively, our new Cables2 knock-in reporter model will enable the comprehensive analysis of in vivo CABLES2 function. 相似文献
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Chaudhari Diptaraj Kiran Shashi Choudhary Ashish Silveira Kris Narwade Nitin Dhotre Dhiraj Khazir Jabeena Mir Bilal Ahmad Shouche Yogesh S. Rahi Praveen 《International microbiology》2023,26(2):257-267
International Microbiology - Indian lotus (Nelumbo nucifera) is one of the dominant aquatic plants cultivated in Dal Lake, situated at 1586 m above mean sea level (MSL) in the northeast of... 相似文献
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Seyyed Jaber Hosseini Zeinolabedin Tahmasebi-Sarvestani Ali Mokhtassi-Bidgoli Hamed Keshavarz Shahryar Kazemi Masoumeh Khalvandi Hematollah Pirdashti Seyyed Hamidreza Hashemi-Petroudi Silvana Nicola 《化学与生物多样性》2023,20(4):e202200247
Saline stress is responsible for significant reductions in the growth of plants, and it globally leads to limitations in the performance of crops, especially in drought-affected areas. However, a better understanding of the mechanisms involved in the resistance of plants to environmental stress can lead to a better plant breeding and selection of cultivars. Mint is one of the most important medicinal plants, and it has important properties for industry, and for the medicinal and pharmacy fields. The effects of salinity on the biochemical and enzymatic properties of 18 ecotypes of mint from six different species, that is, Mentha piperita, Mentha mozafariani, Mentha rotundifolia, Mentha spicata, Mentha pulegium and Mentha longifolia, have been examined in this study. The experimental results showed that salinity increased with increasing in stress integrity influenced the enzymatic properties, proline content, electrolyte leakage, and the hydrogen peroxide, malondialdehyde, and essential oil contents. Cluster analysis and principal component analysis were conducted, and they grouped the studied species on the basis of their biochemical characteristics. According to the obtained biplot results, M. piperita and M. rotundifolia showed better stress tolerance than the other varieties, and M. longifolia was identified as being salt sensitive. Generally, the results showed that H2O2 and malondialdehyde had a positive connection with each other and showed a reverse relationship with all the enzymatic and non-enzymatic antioxidants. Finally, it was found that the M. spicata, M. rotundifolia and M. piperita ecotypes could be used for future breeding projects to improve the salinity tolerance of other ecotypes. 相似文献
17.
Biomechanics and Modeling in Mechanobiology - In this paper, the tools of dynamical systems theory are applied to examine the streamline patterns and their local and global bifurcations for... 相似文献
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Ali HI Tomita K Akaho E Kambara H Miura S Hayakawa H Ashida N Kawashima Y Yamagishi T Ikeya H Yoneda F Nagamatsu T 《Bioorganic & medicinal chemistry》2007,15(1):242-256
Novel 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides were prepared as a new class of antitumor agents and showed significant antitumor activities against NCI-H 460, HCT 116, A 431, CCRF-HSB-2, andKB cell lines. In vivo investigation, 2-deoxo-10-methyl-2-phenyl-5-deazaflavin exhibited the effective antitumor activity against A 431 human adenocarcinoma cells transplanted subcutaneously into nude mouse. Furthermore, AutoDock study has been done by binding of the flavin analogs into PTK pp60(c-src), where a good correlation between their IC(50) and AutoDock binding free energy was exhibited. In particular, 2-deoxo-2-phenylflavin-5-oxides exhibited the highest potential binding affinity within the binding pocket of PTK. 相似文献