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Yi Zhang Lee Opresko Harish Shankaran William B Chrisler H Steven Wiley Haluk Resat 《BMC cell biology》2009,10(1):78
Background
Knowledge about signaling pathways is typically compiled based on data gathered using different cell lines. This approach implicitly assumes that the cell line dependence is not important. However, different cell lines do not always respond to a particular stimulus in the same way, and lack of coherent data collected from closely related cellular systems can be detrimental to the efforts to understand the regulation of biological processes. To address this issue, we created a clone library of human mammary epithelial (HME) cells that expresses different levels of HER2 and HER3 receptors in combination with endogenous EGFR/HER1. Using our clone library, we have quantified the receptor activation patterns and systematically tested the validity of the existing hypotheses about the interaction patterns between HER1-3 receptors. 相似文献153.
Gretchen Tibbits Abdelrhman Mohamed Suzanne Gelston Laure Flurin Yash S. Raval Kerryl E. Greenwood-Quaintance Robin Patel Haluk Beyenal 《Biotechnology and bioengineering》2023,120(1):250-259
The activity of a hypochlorous acid-producing electrochemical bandage (e-bandage) in preventing methicillin-resistant Staphylococcus aureus infection (MRSA) infection and removing biofilms formed by MRSA was assessed using a porcine explant biofilm model. e-Bandages inhibited S. aureus infection (p = 0.029) after 12 h (h) of exposure and reduced 3-day biofilm viable cell counts after 6, 12, and 24 h exposures (p = 0.029). Needle-type microelectrodes were used to assess HOCl concentrations in explant tissue as a result of e-bandage treatment; toxicity associated with e-bandage treatment was evaluated. HOCl concentrations in infected and uninfected explant tissue varied between 30 and 80 µM, decreasing with increasing distance from the e-bandage. Eukaryotic cell viability was reduced by an average of 71% and 65% in fresh and day 3-old explants, respectively, when compared to explants exposed to nonpolarized e-bandages. HOCl e-bandages are a promising technology that can be further developed as an antibiotic-free treatment for wound biofilm infections. 相似文献
154.
In this work, a new approach is proposed to evaluate substrate consumption rate, average biofilm density and active thickness of a spherical bioparticle in a completely mixed fluidized bed system. The substrate consumption rate and average biofilm density are predicted for a given biofilm surface substrate concentration and operational biofilm thickness. A diffusion and reaction model is developed with an effective diffusion coefficient that depends on the average biofilm density. This approach, a first in the literature, predicts the optimum average density of a biofilm to yield the maximum substrate consumption rate within the biofilm. A reasonable correlation was observed between the model prediction and experimental results for substrate consumption rate and average biofilm density for thin and fully active biofilms. 相似文献
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B. Fontaine Sophie Nicole Haluk Topaloglu C. Ben Hamida Peter Beighton Frank Spaans Jose M. A. Cantu Salim Bakouri Norma Romero K. Ricker Patricio Barros-Nunez Gérard Ponsot M. Ben Hamida Jean Weissenbach F. Hentati Frank Lehmann-Horn 《Human genetics》1996,98(3):380-385
Schwartz-Jampel syndrome (SJS), or chondrodystrophic myotonia, is a rare autosomal recessive disorder characterized by generalized
myotonia resulting in a particular, recognizable facies and osteoarticular abnormalities. Some of us have recently shown genetic
linkage of SJS to a locus on 1p34–p36.1 in five families. Here, we show by homozygosity mapping and segregation analysis that
eight new families are most likely linked to the SJS locus on chromosome 1, confirming the localization of SJS to chromosome
1p and suggesting genetic homogeneity. Recombination events reduced the SJS locus from a genetic interval of 8 to 3 cM, which
should facilitate the identification of the SJS gene. Low clinical variability was observed between the studied families,
except for osteoarticular abnormalities. Since the severity and the location of osteoarticular abnormalities varied from one
individual to another, even in the same families, other factors than the SJS gene itself, genetic or epigenetic, might contribute
to the phenotype.
Received: 11 February 1996 / Revised: 6 April 1996 相似文献