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The Fourier transform infrared spectra of 15 purified retinoids were compared. Retinoids with conjugated C = O groups revealed the presence of a band between 1730 and 1630 cm-1 X A characteristic of retinoids is the presence of a band between 1650 and 1620 cm-1 due to C = C stretching where three to four conjugated C = O and C = C bonds were present or between 1610 and 1555 cm-1 where more conjugated unsaturations were present. The presence of cis double bonds was confirmed by a band at 1380 cm-1 while unsubstituted trans double bonds gave absorbances at 990 to 955 cm-1. Epoxy rings, which are present in some retinoids, resulted in bands at 1250, 880, and 790 cm-1 while a furan structure was confirmed by bands at 1175, 1083, and 1065 cm-1. 相似文献
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Barbora de Courten Michaela Jakubova Maximilian PJ de Courten Ivica Just Kukurova Silvia Vallova Patrik Krumpolec Ladislav Valkovic Timea Kurdiova Davide Garzon Silvia Barbaresi Helena J. Teede Wim Derave Martin Krssak Giancarlo Aldini Jozef Ukropec Barbara Ukropcova 《Obesity (Silver Spring, Md.)》2016,24(5):1027-1034
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Charlotte Bezzina Laure Verret Cécile Juan Jessica Remaud Hélène Halley Claire Rampon Lionel Dahan 《PloS one》2015,10(3)
Cortical and hippocampal hypersynchrony of neuronal networks seems to be an early event in Alzheimer’s disease pathogenesis. Many mouse models of the disease also present neuronal network hypersynchrony, as evidenced by higher susceptibility to pharmacologically-induced seizures, electroencephalographic seizures accompanied by spontaneous interictal spikes and expression of markers of chronic seizures such as neuropeptide Y ectopic expression in mossy fibers. This network hypersynchrony is thought to contribute to memory deficits, but whether it precedes the onset of memory deficits or not in mouse models remains unknown. The earliest memory impairments in the Tg2576 mouse model of Alzheimer’s disease have been observed at 3 months of age. We thus assessed network hypersynchrony in Tg2576 and non-transgenic male mice at 1.5, 3 and 6 months of age. As soon as 1.5 months of age, Tg2576 mice presented higher seizure susceptibility to systemic injection of a GABAA receptor antagonist. They also displayed spontaneous interictal spikes on EEG recordings. Some Tg2576 mice presented hippocampal ectopic expression of neuropeptide Y which incidence seems to increase with age among the Tg2576 population. Our data reveal that network hypersynchrony appears very early in Tg2576 mice, before any demonstrated memory impairments. 相似文献
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N.L. Rockley B.A. Halley E.C. Nelson 《Biochimica et Biophysica Acta (BBA)/General Subjects》1980,627(3):270-275
The oxidative decarboxylation of retinoic acid was investigated utilizing a model system concisting of all-trans-retinoic acid, H2O2 and horseradish peroxidase. The decarboxylation products were purified by high-performance liquid chromatography on bonded, octadecylsilane columns. Based on mass spectral, nuclear magnetic resonance, ultraviolet and Fourier transform infrared analyses, the major decarboxylation product was identified as a 4-oxo-C19 aldehyde with a hyrdoxyl group on the side chain at C9, specifically 8-(2,6,6,-trimethyl-3-oxocyclohex-1-enyl)2,6-dimethyl-6-hydroxyoctatrienal. 相似文献
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Background
Amino acid repeat-containing proteins have a broad range of functions and their identification is of relevance to many experimental biologists. In human-infective protozoan parasites (such as the Kinetoplastid and Plasmodium species), they are implicated in immune evasion and have been shown to influence virulence and pathogenicity. RepSeq is a new database of amino acid repeat-containing proteins found in lower eukaryotic pathogens. The RepSeq database is accessed via a web-based application which also provides links to related online tools and databases for further analyses. 相似文献60.
Victor Certal Frank Halley Angela Virone-Oddos Fabienne Thompson Bruno Filoche-Rommé Youssef El-Ahmad Jean-Christophe Carry Cécile Delorme Andreas Karlsson Pierre-Yves Abecassis Loic Vincent Hélène Bonnevaux Jean-Paul Nicolas Renaud Morales Nadine Michot Isabelle Vade Audrey Louboutin Sébastien Perron Gilles Doerflinger Bernadette Tric Laurent Schio 《Bioorganic & medicinal chemistry letters》2012,22(20):6381-6384
From a HTS campaign, a new series of pyrimidone anilides exemplified by compound 1 has been identified with good inhibitory activity for the PI3Kβ isoform. The structure of compound 1 in PI3Kγ was solved revealing a binding mode in agreement with the SAR observed on PI3Kβ. These compounds displayed inhibition in the nanomolar range in the biochemical assay and were also potent p-Akt inhibitors in a PTEN-deficient PC3 prostate cancer cell line. Optimization of in vitro pharmocokinetic properties led to compound 25 exhibiting 52% bioavailability in mice and target engagement in an acute PK/PD study. 相似文献