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排序方式: 共有247条查询结果,搜索用时 171 毫秒
241.
Natalia Prevarskaya Halima Ouadid-Ahidouch Roman Skryma Yaroslav Shuba 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2014,369(1638)
Cancer involves defects in the mechanisms underlying cell proliferation, death and migration. Calcium ions are central to these phenomena, serving as major signalling agents with spatial localization, magnitude and temporal characteristics of calcium signals ultimately determining cell''s fate. Cellular Ca2+ signalling is determined by the concerted action of a molecular Ca2+-handling toolkit which includes: active energy-dependent Ca2+ transporters, Ca2+-permeable ion channels, Ca2+-binding and storage proteins, Ca2+-dependent effectors. In cancer, because of mutations, aberrant expression, regulation and/or subcellular targeting of Ca2+-handling/transport protein(s) normal relationships among extracellular, cytosolic, endoplasmic reticulum and mitochondrial Ca2+ concentrations or spatio-temporal patterns of Ca2+ signalling become distorted. This causes deregulation of Ca2+-dependent effectors that control signalling pathways determining cell''s behaviour in a way to promote pathophysiological cancer hallmarks such as enhanced proliferation, survival and invasion. Despite the progress in our understanding of Ca2+ homeostasis remodelling in cancer cells as well as in identification of the key Ca2+-transport molecules promoting certain malignant phenotypes, there is still a lot of work to be done to transform fundamental findings and concepts into new Ca2+ transport-targeting tools for cancer diagnosis and treatment. 相似文献
242.
Dawood Mahmoud A. O. Zommara Mohsen Eweedah Nabil M. Helal Azmy I. 《Biological trace element research》2020,195(2):624-635
Biological Trace Element Research - The present study was conducted to investigate the effects of nano-selenium (Nano Se) or/and vitamin E (VE) on growth performance, blood health, intestinal... 相似文献
243.
Romain Gasser Marc Cloutier Jérémie Prévost Corby Fink Éric Ducas Shilei Ding Nathalie Dussault Patricia Landry Tony Tremblay Audrey Laforce-Lavoie Antoine Lewin Guillaume Beaudoin-Bussières Annemarie Laumaea Halima Medjahed Catherine Larochelle Jonathan Richard Gregory A. Dekaban Jimmy D. Dikeakos Andrés Finzi 《Cell reports》2021,34(9):108790
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244.
Ashraf A. Dawood Amany A. Saleh Osama Elbahr Suzy Fawzy Gohar Mona S. Habieb 《Biochemistry and Biophysics Reports》2021
Background and aimHepatocellular carcinoma (HCC) is a major health burden globally. Dysregulation of miRNA 148a-3p is engaged in carcinogenesis. TGF-β is a profibrogenic cytokine. This study assesses the expression level of miRNA 148a-3p and its relationship with serum TGF-β1 and fibrosis index based on four factors (FIB-4) in Egyptian patients with HCV-associated HCC.Subjectsand Methods: The study included 72 HCC patients with HCV, 48 HCV cirrhotic patients, and 47 healthy controls. Serum TGF-β1 was assessed by ELISA and the expression of miRNA 148a-3p was measured by RT-PCR.ResultsPatients with HCC had lower plasma miRNA 148a-3p, higher serum TGF-β1, and higher FIB-4 levels than patients with cirrhosis and controls. miRNA 148a-3p discriminated HCC either from control (AUC: 0.997, 95.83% sensitivity, 85.11% specificity) or from cirrhosis (AUC: 0.943, 91.67% sensitivity, 81.25% specificity). Moreover, it distinguished metastatic from nonmetastatic patients (AUC: 0.800, 88.89% sensitivity, 60.0% specificity). The decreased miRNA 148a-3p and the increased TGF-β1 levels were related to distant metastasis, multinodular lesions, advanced TNM stage, and BCLC score (C). A negative correlation between miRNA 148a-3p and each of FIB-4 and TGF-β1 was detected. The decreased miRNA 148a-3p was associated with poor overall survival and poor progression-free survival.ConclusionAn inverse relationship between miRNA 148a-3p and both TGF-β1 and FIB-4 was observed, which could be involved in HCC pathogenesis. Moreover, this miRNA is a potential diagnostic and prognostic biomarker for HCC. 相似文献
245.
246.
Raina N. Fichorova Hidemi S. Yamamoto Titilayo Fashemi Evan Foley Stanthia Ryan Noah Beatty Hassan Dawood Gary R. Hayes Guillaume St-Pierre Sachiko Sato Bibhuti N. Singh 《The Journal of biological chemistry》2016,291(2):998-1013
Trichomoniasis is the most common non-viral sexually transmitted infection caused by the vaginotropic extracellular protozoan parasite Trichomonas vaginalis. The infection is recurrent, with no lasting immunity, often asymptomatic, and linked to pregnancy complications and risk of viral infection. The molecular mechanisms of immune evasion by the parasite are poorly understood. We demonstrate that galectin-1 and -3 are expressed by the human cervical and vaginal epithelial cells and act as pathogen-recognition receptors for the ceramide phosphoinositol glycan core (CPI-GC) of the dominant surface protozoan lipophosphoglycan (LPG). We used an in vitro model with siRNA galectin knockdown epithelial clones, recombinant galectins, clinical Trichomonas isolates, and mutant protozoan derivatives to dissect the function of galectin-1 and -3 in the context of Trichomonas infection. Galectin-1 suppressed chemokines that facilitate recruitment of phagocytes, which can eliminate extracellular protozoa (IL-8) or bridge innate to adaptive immunity (MIP-3α and RANTES (regulated on activation normal T cell expressed and secreted)). Silencing galectin-1 increased and adding exogenous galectin-1 suppressed chemokine responses to Trichomonas or CPI-GC/LPG. In contrast, silencing galectin-3 reduced IL-8 response to LPG. Live Trichomonas depleted the extracellular levels of galectin-3. Clinical isolates and mutant Trichomonas CPI-GC that had reduced affinity to galectin-3 but maintained affinity to galectin-1 suppressed chemokine expression. Thus via CPI-GC binding, Trichomonas is capable of regulating galectin bioavailability and function to the benefit of its parasitic survival. These findings suggest novel approaches to control trichomoniasis and warrant further studies of galectin-binding diversity among clinical isolates as a possible source for symptom disparity in parasitic infections. 相似文献
247.
Physiological and biochemical effects of Olea europaea leaf extracts from four phenological growth stages on the oogenesis of female locust Locusta migratoria
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Khemais Abdellaoui Meriem Hazzoug Olfa Boussadia Meriam Miladi Ghofrane Omri Fatma Acheuk Monia Ben Halima‐Kamel Mohamed Brahem 《Physiological Entomology》2018,43(2):129-139
The effects of olive leaf extract (OLE) are studied on several reproductive variables and the ovarian biochemical composition of Locusta migratoria (Orthoptera: Acrididae) adult females. The methanolic extracts are prepared from the leaves sampled during four phenological growth stages of olive tree: cluster formation (Cf), swelling inflorescence buds (Sib), full flowering (Ff) and endocarp hardening (Eh). When applied to adult females during the pre‐ovipositional phase, the treatment elicites a significant adverse effect on their reproductive potential. Indeed, OLE significantly reduces both fecundity and fertility and affects oocyte growth during the first gonadotrophic cycle, as indicated by measurements of ovarian weight, length of terminal oocytes and ovarian index. Furthermore, OLE is examined with respect to ovarian biochemical components. Biochemical analyses reveal a significant reduction of ovarian contents of proteins, lipids and carbohydrates, suggesting a disruption in the incorporation of the haemolymph metabolites in the oocytes and an interference of OLE with the vitellogenesis process. The antigonadotrophic effect is confirmed by a histological study of the ovaries, which clearly shows a delay in ovarian development and in yolk accumulation in the basal oocytes of treated females. The most effect is noted with the extract prepared from the leaves collected at the swelling inflorescence buds for all measured parameters, which appears to be related to its high content of polyphenols. 相似文献