全文获取类型
收费全文 | 5061篇 |
免费 | 549篇 |
国内免费 | 826篇 |
专业分类
6436篇 |
出版年
2024年 | 31篇 |
2023年 | 141篇 |
2022年 | 213篇 |
2021年 | 343篇 |
2020年 | 249篇 |
2019年 | 322篇 |
2018年 | 256篇 |
2017年 | 197篇 |
2016年 | 303篇 |
2015年 | 382篇 |
2014年 | 437篇 |
2013年 | 476篇 |
2012年 | 489篇 |
2011年 | 477篇 |
2010年 | 281篇 |
2009年 | 228篇 |
2008年 | 280篇 |
2007年 | 203篇 |
2006年 | 168篇 |
2005年 | 129篇 |
2004年 | 125篇 |
2003年 | 125篇 |
2002年 | 117篇 |
2001年 | 78篇 |
2000年 | 54篇 |
1999年 | 58篇 |
1998年 | 38篇 |
1997年 | 40篇 |
1996年 | 26篇 |
1995年 | 20篇 |
1994年 | 22篇 |
1993年 | 24篇 |
1992年 | 22篇 |
1991年 | 17篇 |
1990年 | 20篇 |
1989年 | 4篇 |
1988年 | 6篇 |
1987年 | 7篇 |
1986年 | 7篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1950年 | 1篇 |
排序方式: 共有6436条查询结果,搜索用时 0 毫秒
31.
Liu Xi Ding Li Yuan Jing Liao Jian Duan Lian Wang Wenfei Tan Weiguo Yu Weiye Zhou Boping Chen Xinchun Yang Zheng 《中国病毒学》2019,34(3):334-337
<正>Dear Editor,H7 N9 is a recently identified subtype of influenza A virus that caused a major outbreak in humans in China in 2013.According to the latest data provided by the Chinese Center for Disease Control and Prevention(http://www.moh.gov.cn/zwgk/yqbb3/ejlist.shtml, updated on October 31, 2018),the mortality rate of H7 N9 infections in China amounts to 相似文献
32.
Plastome phylogeny and lineage diversification of Salicaceae with focus on poplars and willows 下载免费PDF全文
Phylogenetic relationships and lineage diversification of the family Salicaceae sensu lato (s.l.) remain poorly understood. In this study, we examined phylogenetic relationships between 42 species from six genera based on the complete plastomes. Phylogenetic analyses of 77 protein coding genes of the plastomes produced good resolution of the interrelationships among most sampled species and the recovered clades. Of the sampled genera from the family, Flacourtia was identified as the most basal and the successive clades comprised both Itoa and Poliothyrsis, Idesia, two genera of the Salicaceae sensu stricto (s.s.) (Populus and Salix). Five major subclades were recovered within the Populus clade. These subclades and their interrelationships are largely inconsistent with morphological classifications and molecular phylogeny based on nuclear internal transcribed spacer sequence variations. Two major subclades were identified for the Salix clade. Molecular dating suggested that species diversification of the major subclades in the Populus and Salix clades occurred mainly within the recent Pliocene. In addition, we found that the rpl32 gene was lost and the rps7 gene evolved into a pseudogene multiple times in the sampled genera of the Salicaceae s.l. Compared with previous studies, our results provide a well‐resolved phylogeny from the perspective of the plastomes. 相似文献
33.
Summary . We derive estimates of the minimum capture proportion required to obtain a reliable estimate of the population size for several continuous and discrete-time capture–recapture models. The models considered are , and in the notation of Otis et al. , (1978, Wildlife Monograph 62 , 1–135). Numerical results with simulation studies are given, and two real examples for the model are also considered. Potential applications of these results are suggested. 相似文献
34.
35.
Oxidized low density lipoprotein (oxLDL) is believed to play a central role in atherogenesis. LDL is oxidized in the arterial intima by mechanisms that are still only partially understood. OxLDL is then taken up by macrophages through scavenger receptor-mediated endocytosis, which then leads to cellular damage, including apoptosis. The complex mechanisms by which oxLDL induces cell injury are mostly unknown. This study has demonstrated that oxLDL-induced damage of macrophages is associated with iron-mediated intralysosomal oxidative reactions, which cause partial lysosomal rupture and ensuing apoptosis. This series of events can be prevented by pre-exposing cells to the iron-chelator, desferrioxamine (DFO), whereas it is augmented by pretreating the cells with a low molecular weight iron complex. Since both DFO and the iron complex would be taken up by endocytosis, and thus directed to the lysosomal compartment, the results suggest that the normal contents of lysosomal low molecular weight iron may play an important role in oxLDL-induced cell damage, presumably by catalyzing intralysosomal fragmentation of lipid peroxides and the formation of toxic aldehydes and oxygen-centered radicals. 相似文献
36.
采用RNA斑点杂交分析,对21例人脑原发性胶质瘤和11例人脑膜瘤中p53,Rb和c-myc基因转录水平的表达进行研究.发现48.4%的肿瘤中p53基因表达减弱,21.9%的肿瘤中Rb基因表达减弱;71.9%的肿瘤中c-myc基因表达增强.在p53基因表达减弱的15例病例中有13例(80%)c-myc基因表达增强.结果表明,p53基因表达减弱和c-myc基因表达增强与人脑原发性肿瘤的发生有关. 相似文献
37.
Jian-Guo Hu Xing-Jun Wu Yi-Fan Feng Gang-ming Xi Ling-Xiao Deng Zhen-Huan Wang Rui Wang Lin Shen Jian-Sheng Zhou He-Zuo Lü 《Neurochemical research》2013,38(3):601-609
The conditioned medium from B104 neuroblastoma cells (B104CM) induces proliferation of oligodendrocyte progenitor cells (OPCs) in vitro. However, the molecular events that occur during B104CM-induced proliferation of OPCs has not been well clarified. In the present study, using OPCs immunopanned from embryonic day 14 Sprague–Dawley rat spinal cords, we explored the activation of several signaling pathways and the expression of several important immediate early genes (IEGs) and cyclins in OPCs in response to B104CM. We found that B104CM can induce OPC proliferation through the activation of the extracellular signal-regulated kinases 1 and 2 (Erk1/2), but not PI3K or p38 MAPK signaling pathways in vitro. The IEGs involved in B104CM-induced OPC proliferation include c-fos, c-jun and Id2, but not c-myc, fyn, or p21. The cyclins D1, D2 and E are also involved in B104CM-stimulated proliferation of OPCs. The activation of Erk results in subsequent expression of IEGs (such as c-fos, c-jun and Id-2) and cyclins (including cyclin D1, D2 and E), which play key roles in cell cycle initiation and OPC proliferation. Collectively, these results suggest that the phosphorylation of Erk1/2 is an important molecular event during OPC proliferation induced by B104CM. 相似文献
38.
39.
40.
Zhijiang Yan Mathieu Delannoy Chen Ling Danielle Daee Fekret Osman Parameswary A. Muniandy Xi Shen Anneke B. Oostra Hansen Du Jurgen Steltenpool Ti Lin Beatrice Schuster Chantal Décaillet Andrzej Stasiak Alicja Z. Stasiak Stacie Stone Maureen E. Hoatlin Detlev Schindler Christopher L. Woodcock Hans Joenje Weidong Wang 《Molecular cell》2010,37(6):865-878