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排序方式: 共有178条查询结果,搜索用时 109 毫秒
81.
Peters U Hutter CM Hsu L Schumacher FR Conti DV Carlson CS Edlund CK Haile RW Gallinger S Zanke BW Lemire M Rangrej J Vijayaraghavan R Chan AT Hazra A Hunter DJ Ma J Fuchs CS Giovannucci EL Kraft P Liu Y Chen L Jiao S Makar KW Taverna D Gruber SB Rennert G Moreno V Ulrich CM Woods MO Green RC Parfrey PS Prentice RL Kooperberg C Jackson RD Lacroix AZ Caan BJ Hayes RB Berndt SI Chanock SJ Schoen RE Chang-Claude J Hoffmeister M Brenner H Frank B Bézieau S Küry S Slattery ML Hopper JL Jenkins MA 《Human genetics》2012,131(2):217-234
Colorectal cancer is the second leading cause of cancer death in developed countries. Genome-wide association studies (GWAS) have successfully identified novel susceptibility loci for colorectal cancer. To follow up on these findings, and try to identify novel colorectal cancer susceptibility loci, we present results for GWAS of colorectal cancer (2,906 cases, 3,416 controls) that have not previously published main associations. Specifically, we calculated odds ratios and 95% confidence intervals using log-additive models for each study. In order to improve our power to detect novel colorectal cancer susceptibility loci, we performed a meta-analysis combining the results across studies. We selected the most statistically significant single nucleotide polymorphisms (SNPs) for replication using ten independent studies (8,161 cases and 9,101 controls). We again used a meta-analysis to summarize results for the replication studies alone, and for a combined analysis of GWAS and replication studies. We measured ten SNPs previously identified in colorectal cancer susceptibility loci and found eight to be associated with colorectal cancer (p value range 0.02 to 1.8?×?10(-8)). When we excluded studies that have previously published on these SNPs, five SNPs remained significant at p?0.05 in the combined analysis. No novel susceptibility loci were significant in the replication study after adjustment for multiple testing, and none reached genome-wide significance from a combined analysis of GWAS and replication. We observed marginally significant evidence for a second independent SNP in the BMP2 region at chromosomal location 20p12 (rs4813802; replication p value 0.03; combined p value 7.3?×?10(-5)). In a region on 5p33.15, which includes the coding regions of the TERT-CLPTM1L genes and has been identified in GWAS to be associated with susceptibility to at least seven other cancers, we observed a marginally significant association with rs2853668 (replication p value 0.03; combined p value 1.9?×?10(-4)). Our study suggests a complex nature of the contribution of common genetic variants to risk for colorectal cancer. 相似文献
82.
Mathieu Lemire Conghui Qu Lenora W. M. Loo Syed H. E. Zaidi Hansong Wang Sonja I. Berndt Stéphane Bézieau Hermann Brenner Peter T. Campbell Andrew T. Chan Jenny Chang-Claude Mengmeng Du Christopher K. Edlund Steven Gallinger Robert W. Haile Tabitha A. Harrison Michael Hoffmeister John L. Hopper Lifang Hou Li Hsu Eric J. Jacobs Mark A. Jenkins Jihyoun Jeon Sébastien Küry Li Li Noralane M. Lindor Polly A. Newcomb John D. Potter Gad Rennert Anja Rudolph Robert E. Schoen Fredrick R. Schumacher Daniela Seminara Gianluca Severi Martha L. Slattery Emily White Michael O. Woods Michelle Cotterchio Loïc Le Marchand Graham Casey Stephen B. Gruber Ulrike Peters Thomas J. Hudson 《Human genetics》2015,134(11-12):1249-1262
83.
Foster Bryan S. Haile Brendan B. Campnell Justin T. Canam Thomas Gallagher Marci J. Meiners Scott J. 《Plant Ecology》2022,223(2):201-212
Plant Ecology - Plant–soil microbe interactions are a key determinant of plant community composition and structure, with each plant species generating a unique soil microbiota. However, the... 相似文献
84.
The inhibition of the corrosive action of Acidithiobacillus thiooxidans on concrete specimens coated by functionalised zeolite-A containing 14% zinc and 5% silver by weight was studied. Uncoated concrete specimens, epoxy-coated concrete specimens (EP), and functionalised zeolite-A coated concrete specimens with epoxy to zeolite weight ratios of 3:1 (Z1), 2:2 (Z2) and 1:3 (Z3) were studied. Specimens were characterised by x-ray powder diffraction and field emission scanning electron microscopy for the identification of corrosion products and morphological changes. Biomass growth at the conclusion of the 32-day experiments was 4, 179 and 193 mg volatile suspended solids g(-1) sulphur for the uncoated, EP and Z1 specimens, whereas that of Z2 and Z3 were negligible. In the uncoated, EP and Z1 specimens, sulphate production rates were 0.83, 9.1 and 8.8 mM SO(4)(2-) day(-1) and the specific growth rates, mu, were 0.14, 0.57 and 0.47 day(-1), respectively. The corresponding values for Z2 and Z3 were negligible due to their bacterial inhibition characteristics. 相似文献
85.
86.
Warmus JS Flamme C Zhang LY Barrett S Bridges A Chen H Gowan R Kaufman M Sebolt-Leopold J Leopold W Merriman R Ohren J Pavlovsky A Przybranowski S Tecle H Valik H Whitehead C Zhang E 《Bioorganic & medicinal chemistry letters》2008,18(23):6171-6174
This paper reports a second generation MEK inhibitor. The previously reported potent and efficacious MEK inhibitor, PD-184352 (CI-1040), contains an integral hydroxamate moiety. This compound suffered from less than ideal solubility and metabolic stability. An oxadiazole moiety behaves as a bioisostere for the hydroxamate group, leading to a more metabolically stable and efficacious MEK inhibitor. 相似文献
87.
88.
Hamasur B Bruchfeld J Haile M Pawlowski A Bjorvatn B Källenius G Svenson SB 《Journal of microbiological methods》2001,45(1):41-52
There is an urgent need for improved tools for laboratory diagnosis of active tuberculosis (TB). Here, we describe two methods, a catch-up ELISA and a dipstick test based on the detection in urine of lipoarabinomannan (LAM). LAM is a major and specific glycolipid component of the outer mycobacterial cell wall. Preliminary experiments showed that LAM is excreted in the urine of mice injected intraperitoneally with a crude cell wall preparation of Mycobacterium tuberculosis. Both methods were highly sensitive, detecting LAM at concentrations of 1 ng/ml and 5 pg/ml, respectively. Of 15 patients with active TB, all showed intermediate to high levels of LAM in their urine (absorbance values from 0.3 to 1.2, mean 0.74). Only one sample showed an absorbance value below the chosen cut off value of 0.4. All but one of the urine samples from 26 healthy nursing workers exhibited OD value below 0.4 cut off. These methods may prove valuable for rapid and simple diagnosis of TB in particular in developing countries lacking biosafety level 3 (BSL3) facilities. 相似文献
89.
Yang F Haile DJ Berger FG Herbert DC Van Beveren E Ghio AJ 《American journal of physiology. Lung cellular and molecular physiology》2003,284(2):L402-L409
The biological functions of the acute- phase protein haptoglobin (Hp) may be related to its ability to bind hemoglobin (Hb) or to modulate immune response. Hp is expressed at a high level in lung cells, yet its protective role(s) in the lung is not known. With the use of transgenic mice overexpressing Hp in alveolar macrophages, we demonstrated that Hp diminished Hb-induced lung injury when the lung was exposed to whole blood. In transgenic mouse lungs, Hb was more efficiently removed, and the induction of stress- responsive heme oxygenase-1 gene was significantly lower when compared with wild-type mice. At 24 h after blood treatment, the ferritin level that serves as an index for intracellular iron content was also lower in alveolar macrophages in transgenic mice than in wild-type mice. We propose that an Hp-mediated Hb catabolism process exists in alveolar macrophages. This process is likely coupled to an iron mobilization pathway and may be an efficient mechanism to reduce oxidative damage associated with hemolysis. 相似文献
90.
Insecticides are used extensively on lettuce, Lactuca sativa L., grown in southwestern Arizona because of heavy insect pressure that can potentially reduce lettuce productivity. Multiple sprays are made per season to manage these insects in lettuce. One of the major concerns related to extensive insecticide applications in lettuce is the potential subtle impact of insecticides that may reduce lettuce photosynthesis and yield. We conducted field and greenhouse experiments to examine the impact of multiple insecticides and surfactant spray applications on lettuce photosynthesis and yield. Lettuce was planted in the field in 1998, insecticides and surfactant were applied, and lettuce gas-exchange and dry weights were determined. Treatments were arranged in a split-plot consisting of insecticides as main plot and surfactant as subplot treatments in a randomized complete block design with four replications. Photosynthetic rates of lettuce were significantly reduced by endosulfan, methomyl, acephate, and surfactant at seedling stage 4 h and 2 d after the spray application was made. However, the reduction in lettuce photosynthesis by these insecticides and surfactant was only transient, and lettuce photosynthesis recovered 5 d after the spray application was made. Photosynthetic rates were not altered by zeta-cypermethrin, emamectin benzoate, and spinosad at the seedling stage. Insecticides or surfactant (Kinetic, a nonionic surfactant) did not significantly affect lettuce photosynthesis after rosette formation. In addition, lettuce dry weight was not significantly altered. These studies suggest that lettuce photosynthesis may be susceptible to some insecticides at the seedling stage. Consequently, we found that biorational insecticides, introduced to manage insect pests in lettuce, have no influence on lettuce physiology at the seedling stage, unlike the chlorinated hydrocarbons, organophosphates, or carbamates tested in this study. In a greenhouse study, we found that lettuce photosynthesis and yield were not altered by Bacillus thuringiensis application. Our results indicate that B. thuringiensis and the newer insecticides, particularly biorationals, can be used to manage lettuce insect pests without significantly altering lettuce gas-exchange and yield. 相似文献