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161.
Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells 下载免费PDF全文
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Genetic characterization of high-level gentamicin-resistant strains of Enterococcus faecalis in Iran
Feizabadi MM Asadi S Zohari M Gharavi S Etemadi G 《Canadian journal of microbiology》2004,50(10):869-872
The prevalence of resistance to high levels of gentamicin among 182 isolates of Enterococcus faecalis from 2 Iranian hospitals was 42%. Gentamicin resistance was associated with conjugative plasmids (>70 kb) in most strains. Fingerprinting using EcoRI and HindIII showed genetic variation among these plasmids and gave evidence of nosocomial outbreaks and persistence of infection in different wards of the study hospitals, as well as transfer of plasmids between genetically diverse isolates. Using EcoRI, hospital-based specific plasmid fingerprints were detected for the isolates that had previously proved to be unrelated by multilocus enzyme electrophoresis, suggesting the persistence of related plasmids at each hospital, though minor changes in these related plasmids could be detected with HindIII. 相似文献
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Both the trans and cis isomers of [Ru(acac)2{P(OMe)3}2] were isolated in the form of single crystals and characterized by single crystal X-ray diffraction, UV-Vis, MS, 1H, 13C and 31P NMR spectroscopy. The compounds of ruthenium(II), both mononuclear complexes, crystallize in triclinic space group. The metal ion in both compounds has similar, slightly distorted octahedral coordination geometry. Both complexes were tested as catalyst in hydrogen generation from the hydrolysis of sodium borohydride. When used alone, none of the trans- and cis-[Ru(acac)2{P(OMe)3}2] complexes shows significant catalytic activity. However, the catalytic activity of cis-[Ru(acac)2{P(OMe)3}2] in the hydrolysis of sodium borohydride is significantly enhanced by the addition of two equivalents of trimethylphosphite per ruthenium into the medium. 相似文献
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Sohrabi N Hassan ZM Khosravi AR Tebianian M Mahdavi M Tootian Z Ebrahimi SM Yadegari MH Gheflati Z 《Canadian journal of microbiology》2010,56(9):771-776
Invasive aspergillosis increases in chronic immunosuppressive diseases such as cancer. There is little information about the mechanisms by which Aspergillus infection affects the immune regulation and microenvironment of cancer cells. Hence, this study was aimed at investigating the effect of invasive aspergillosis on immunosurveillance, metastasis, and prognosis of cancer in tumor-bearing mice. After implantation of mouse mammary tumor in BALB/c mice, they were infected with Aspergillus conidia intravenously. For comparison, groups of mice were experimentally infected with Aspergillus conidia or implanted with tumor cells separately. Seven days after Aspergillus infection, the serum levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) were measured by ELISA, and subsequently regulatory T lymphocytes were analyzed by flow cytometry. The survival of animals and mean tumor size were then determined. Our results indicated that tumor sizes in mice increased significantly after infection with Aspergillus conidia. Moreover, invasive aspergillosis enhanced the population of regulatory lymphocytes and level of TIMP-1. This study supports the idea that massive Aspergillus infection could stimulate tumor growth and increases the possibility of a bad prognosis. As a result, treatment of Aspergillus infection could be considered an important issue for efficient cancer therapy. 相似文献
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Razzaghi-Abyaneh M Shams-Ghahfarokhi M Eslamifar A Schmidt OJ Gharebaghi R Karimian M Naseri A Sheikhi M 《Mycopathologia》2006,161(4):245-249
The effects of Akacid plus, a novel guanidine-based polymer first introduced as a biocidal and disinfectant agent were studied on Aspergillus parasiticus growth and its aflatoxin (AF) productivity. The fungus was cultured on yeast extract-sucrose (YES) broth in presence of various twofold serial dilutions of 25% Akacid plus (1.5-96 microL/50 mL medium) and then incubated in shaking condition with 150 rev./min at 28 degrees C for 96 h. Based on obtained results, Akacid plus was found to significantly inhibit both growth and aflatoxin B1 (AFB1) synthesis in very low concentrations in a dose-dependent manner. Fungal growth inhibition was determined in the range of 9.6-99.6% in mycelia exposed to the total concentration range of 1.5-48 microL. A final concentration of 96 microL was necessary to completely inhibit the growth of fungus. Under similar conditions, AFB1 synthesis was found to be strongly inhibited by 8.1-98.0% in presence of 1.5-24 microL Akacid plus with a maximum of 100% by 48 microL concentration. With respect to the unique physico-chemical properties of Akacid plus, its marked inhibitory effects on A. parasiticus growth and its AFB1 synthesis shown for the first time in this study make it a promising candidate for application in prevention programmes of AF contamination of susceptible crops. 相似文献