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281.
Bavat Bornstein Hagar Meltzer Ruth Adler Idan Alyagor Victoria Berkun Gideon Cummings Fabienne Reh Hadas KerenShaul Eyal David Thomas Riemensperger Oren Schuldiner 《The EMBO journal》2021,40(12)
The mechanisms controlling wiring of neuronal networks are not completely understood. The stereotypic architecture of the Drosophila mushroom body (MB) offers a unique system to study circuit assembly. The adult medial MB γ‐lobe is comprised of a long bundle of axons that wire with specific modulatory and output neurons in a tiled manner, defining five distinct zones. We found that the immunoglobulin superfamily protein Dpr12 is cell‐autonomously required in γ‐neurons for their developmental regrowth into the distal γ4/5 zones, where both Dpr12 and its interacting protein, DIP‐δ, are enriched. DIP‐δ functions in a subset of dopaminergic neurons that wire with γ‐neurons within the γ4/5 zone. During metamorphosis, these dopaminergic projections arrive to the γ4/5 zone prior to γ‐axons, suggesting that γ‐axons extend through a prepatterned region. Thus, Dpr12/DIP‐δ transneuronal interaction is required for γ4/5 zone formation. Our study sheds light onto molecular and cellular mechanisms underlying circuit formation within subcellular resolution. 相似文献
282.
Anat Lerner Susana Castro-Sowinski Hadas Lerner Yaacov Okon & Saul Burdman 《FEMS microbiology letters》2009,300(1):75-82
Here we report the identification of a glycogen phosphorylase ( glgP ) gene in the plant growth-promoting rhizobacterium Azospirillum brasilense , Sp7, and the characterization of a glgP marker exchange mutant of this strain. The glgP mutant showed a twofold reduction of glycogen phosphorylase activity and an increased glycogen accumulation as compared with wild-type Sp7, indicating that the identified gene indeed encodes a protein with glycogen phosphorylase activity. Interestingly, the glgP mutant had higher survival rates than the wild type after exposure to starvation, desiccation and osmotic pressure. The mutant was shown to be compromised in its biofilm formation ability. Analysis of the exopolysaccharide sugar composition of the glgP mutant revealed a decrease in the amount of glucose, accompanied by increases in rhamnose, fucose and ribose, as compared with the Sp7 exopolysaccharide. To the best of our knowledge, this is the first study that demonstrates GlgP activity in A. brasilense , and shows that glycogen accumulation may play an important role in the stress endurance of this bacterium. 相似文献
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Hadas Hawlena Evelyn Rynkiewicz Evelyn Toh Andrew Alfred Lance A Durden Michael W Hastriter David E Nelson Ruichen Rong Daniel Munro Qunfeng Dong Clay Fuqua Keith Clay 《The ISME journal》2013,7(1):221-223
Bacterial community composition in blood-sucking arthropods can shift dramatically across time and space. We used 16S rRNA gene amplification and pyrosequencing to investigate the relative impact of vertebrate host-related, arthropod-related and environmental factors on bacterial community composition in fleas and ticks collected from rodents in southern Indiana (USA). Bacterial community composition was largely affected by arthropod identity, but not by the rodent host or environmental conditions. Specifically, the arthropod group (fleas vs ticks) determined the community composition of bacteria, where bacterial communities of ticks were less diverse and more dependent on arthropod traits—especially tick species and life stage—than bacterial communities of fleas. Our data suggest that both arthropod life histories and the presence of arthropod-specific endosymbionts may mask the effects of the vertebrate host and its environment. 相似文献
286.
Domestic firewood collection is compared across study sites in Malawi and Tanzania. The study focuses on accommodation of infant-care within wood collection, the influence of family size on firewood demand and the contribution of girls to firewood collection. Malawian women carry their infants on wood collection trips. The Tanzanian women leave their infants behind. The shorter trips of the Tanzanian women, and the ready availability of alloparental care may facilitate this. Mean per capita wood consumption was similar across the two sites. However, a marked economy of scale was evident in wood use at the Malawi site. Girls at both sites assist with wood collection. Their contribution appears more than sufficient to compensate for their own wood use. Having a daughter therefore need not represent a net energetic cost to a woman in terms of firewood acquisition and consumption. While family size and structure appear to influence firewood consumption and acquisition, differences in the environment between the two sites may underpin much of the variation. The longer journey times, heavier load, and less frequent journeys undertaken by Malawian women may reflect the steep terrain and risks associated with firewood collection within a national park. 相似文献
287.