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J. Hackbarth 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1938,10(6):145-150
Zusammenfassung Der Ölgehalt vonL. albus ist eine erbliche Eigenschaft, die von Außenbedingungen verhältnismäßig stark beeinflußt wird.Erhöhend auf den Ölgehalt wirken folgende Außenumstände: Guter Boden, frühe Aussaat, viel Niederschläge im Juni, reichlich Sonnenschein im Juli–August.Der Ölgehalt der Samen einer Pflanze schwankt je nach Insertionsstelle der Hülse im artspezifischen Maße.Zwischen Ölgehalt auf der einen Seite und Korngröße, Reifezeit und Eiweißgehalt auf der anderen bestehen keine Korrelationen.Die aus diesen Beobachtungen zu folgernden Maßnahmen für die Züchtung werden besprochen. 相似文献
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v. Berg Kuckuck Stubbe K. L. Noack v. Witsch v. Berg Lang Hackbarth Schaper Ufer Propach Schratz R. Schick Fuchs Hassebrauk Hans Freytag Zimmermann Beckmann Zimmermann Schmidt W. v. Wettstein Kuckuck 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1937,9(9):239-248
Ohne Zusammenfassung 相似文献
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The recommendations for minimum floor area given in the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes (1986), as well as in the Publication on the Planning and Structure of Animal Facilities for Institutes Performing Animal Experiments of the Society for Laboratory Animal Science (GV-SOLAS 1989), are plotted in a double logarithmic system in order to get an allometric function of recommended floor area to body weight. Both recommendations correspond very well with the so-called metabolic body weight seen at the allometric exponent of 0.73 and 0.70 respectively. Thus the recommendations in general attribute the floor space according to the metabolic body weight of the animal. Nevertheless, despite this general rule, some species are recommended less space than others when measured on this allometric scale. Thus it must be questioned why, for example, rabbits, chicken and pigs are recommended less space than other species. The general allometric measure seems at least to be a good scale for the comparison of recommended floor space, and for the discussion of species-specific needs for more or less space. 相似文献
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The rat tail vascularization is histologically re-examined especially with respect to blood sampling and vascular-injection methods. The terminal third of the tail is recommended for blood vessel puncturing. In this segment, the arteries and veins are most prominent, since the structures of the musculo-skeletal system diminish towards the tip of the tail. In addition to the commonly-known blood vessels (one ventral artery, two lateral veins), there is a dorsal vein in the rat tail that is well suited for puncture and cannulation. 相似文献
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Novel oxazolidinone-quinolone hybrid antimicrobials 总被引:3,自引:0,他引:3
Gordeev MF Hackbarth C Barbachyn MR Banitt LS Gage JR Luehr GW Gomez M Trias J Morin SE Zurenko GE Parker CN Evans JM White RJ Patel DV 《Bioorganic & medicinal chemistry letters》2003,13(23):4213-4216
Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2, 5, and 6 display an improved potency versus linezolid against gram-positive and fastidious gram-negative pathogens. The compounds are also active against linezolid- and ciprofloxacin-resistant Staphylococcus aureus and Enterococcus faecium strains. The MOA for these new antimicrobials is consistent with a combination of protein synthesis and gyrase A/topoisomerase IV inhibition, with a structure-dependent degree of the contribution from each inhibitory mechanism. 相似文献
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Interaction of Native and Mutant MecI Repressors with Sequences That Regulate mecA, the Gene Encoding Penicillin Binding Protein 2a in Methicillin-Resistant Staphylococci 下载免费PDF全文
Vijay K. Sharma Corinne J. Hackbarth Tanja M. Dickinson Gordon L. Archer 《Journal of bacteriology》1998,180(8):2160-2166
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Raju B Anandan S Gu S Herradura P O'Dowd H Kim B Gomez M Hackbarth C Wu C Wang W Yuan Z White R Trias J Patel DV 《Bioorganic & medicinal chemistry letters》2004,14(12):3103-3107
Deoxynegamycin (1b) is a protein synthesis inhibitor with activity against Gram-negative (GN) bacteria. A series of conformationally restricted analogs were synthesized to probe its bioactive conformation. Indeed, some of the constrained analogs were found to be equal or better than deoxynegamycin in protein synthesis assay (1b, IC(50)=8.2 microM; 44, IC(50)=6.6 microM; 35e(2), IC(50)=1 microM). However, deoxynegamycin had the best in vitro whole cell antibacterial activity (Escherichia coli, MIC=4-16 microg/mL; Klebsiella pneumoniae, MIC=8 microg/mL) suggesting that other factors such as permeation may also be contributing to the overall whole cell activity. A new finding is that deoxynegamycin is efficacious in an E. coli murine septicemia model (ED(50)=4.8 mg/kg), providing further evidence of the favorable in vivo properties of this class of molecules. 相似文献