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Jeung Il Kim Tae Wan Kim Sung Min Hong Tae Yong Moon In Sook Lee Kyung Un Choi Hak Sun Yu 《The Korean journal of parasitology》2014,52(1):69-73
Sparganosis is a parasitic infection caused by the plerocercoid tapeworm larva of the genus Spirometra. Although the destination of the larva is often a tissue or muscle in the chest, abdominal wall, extremities, eyes, brain, urinary tract, spinal canal, and scrotum, intramuscular sparganosis is uncommon and therefore is difficult to distinguish from a soft tissue tumor. We report a case of intramuscular sparganosis involving the gastrocnemius muscle in an elderly patient who was diagnosed using ultrasonography and MRI and treated by surgical excision. At approximately 1 cm near the schwannoma at the right distal sciatic nerve, several spargana worms were detected and removed. 相似文献
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Chilling stress-induced proteomic changes in rice roots 总被引:4,自引:0,他引:4
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Yun Hee Baek Jeung Hyun Park Young Jun Song Min-Suk Song Philippe Noriel Q. Pascua Yoon-Soo Hahn Heon-Seok Han Ok-Jun Lee Ki-Soon Kim Chun Kang Young-Ki Choi 《Journal of microbiology (Seoul, Korea)》2009,47(1):91-100
To investigate the genetic characteristics of human influenza viruses circulating in Chungbuk province, we tested 510 clinical
samples of nasopharyngeal suction from pediatric patients diagnosed with respiratory illness between June 2007 and June 2008.
Genetic characterization of the HA genes of H3N2 isolates indicated the relative higher similarity to A/Virginia/04/07 (99.6%)
rather than that of A/Wisconsin/67/2005 (98.4%), a Northern Hemisphere 2007∼2008 vaccine strain, based on amino acid sequences.
We found several altered amino acids at the H3 HA1 antigenic sites compared with the vaccine strain; K140I at site A, K158R
at site B, and K173N (H471) or K173Q, and S262N at site E, but there was no antigenic shift among the H3N2 viruses. Interestingly,
A/Cheongju/H383/08 and A/Cheongju/H407/08 isolates had single amino acid substitution at D151G on the catalytic site of the
N2 NA while A/Cheongju/H412/08 and A/Cheongju/ H398/07 isolates had one amino acid deletion at residue 146. Furthermore, we
found that 25% (3 out of 12 isolates) of the H3N2 subtype viruses had the amino acid substitution at position 31 on the M2
protein (Aspartic acid to Asparagine) and confirmed their drug-resistance by biological assays. Taken together, the results
of this study demonstrated continuous evolutions of human H3N2 viruses by antigenic drift and also highlighted the need to
closely monitor antigenic drug resistance in influenza A viruses to aid in the early detection of potentially pandemic strains,
as well as underscore the need for new therapeutics. 相似文献
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Bo-Mi Lee Geun-Shik Lee Eui-Man Jung Kyung-Chul Choi Eui-Bae Jeung 《Reproductive biology and endocrinology : RB&E》2009,7(1):49
Transient receptor potential cation channel, subfamily V, member 6 (TRPV6) is an epithelial Ca2+ channel protein expressed in calcium absorbing organs. In the present study, we investigated the expression and regulation
of uterine and placental TRPV6 during gestation in rodents. Uterine TRPV6 peaked at pregnancy day (P) 0.5, P5.5 and, P13.5
and was detected in uterine epithelium and glands of rats, while placental TRPV6 mRNA levels increased in mid-gestation. Uterine
and placental TRPV6 mRNA levels in rats appear to cyclically change during pregnancy, suggesting that TRPV6 may participate
in the implantation process. In addition, uterine TRPV6 mRNA is only expressed in placenta-unattached areas of the uterus,
and uterine TRPV6 immunoreactivity was observed in luminal and glandular epithelial cells. In the placenta, TRPV6 was detected
in the labyrinth and spongy zone. These results may indicate that TRPV6 has at least two functions: implantation of the embryo
and maintenance of pregnancy. To investigate the pathway(s) mediating TRPV6 expression in rodents, anti-steroid hormone antagonists
were injected prior to maximal TRPV6 expression. In rats, TRPV6 expression was reduced by RU486 (an anti-progesterone) through
progesterone receptors, and ICI 182,780 (an anti-estrogen) blocked TRPV6 expression via estrogen receptors in mice. The juxtaposition
of uterine and placental TRPV6 expressed in these tissues supports the notion that TRPV6 participates in transferring calcium
ions between the maternal and fetal compartments. Taken together, TRPV6 gene may function as a key element in controlling
calcium transport in the uterus between the embryo and the placenta during pregnancy. 相似文献
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Jeung HC Che XF Haraguchi M Zhao HY Furukawa T Gotanda T Zheng CL Tsuneyoshi K Sumizawa T Roh JK Akiyama S 《FEBS letters》2006,580(5):1294-1302
Thymidine phosphorylase (TP) is involved both in pyrimidine nucleoside metabolism and in angiogenesis. TP also conferred the resistance to hypoxia-induced apoptosis of the cancer cells. In U937 cells, DNA damage-inducing agents significantly enhanced the expression of TP. Cell lines stably transfected with TP cDNA were more resistant to the DNA damage-inducing agents than the mock-transfected cells and showed augmented activity of Akt. The cytoprotective function of TP against DNA damage was independent of its enzymatic activity. The resistance to apoptosis was partially abrogated by treatment with the phosphatidyl inositol 3-kinase (PI3K) inhibitors, suggesting that the cytoprotective function of TP is mediated, at least in part, by regulation of the PI3K/Akt pathway. These findings indicate that TP expression in increased by various stress including DNA damage and that TP molecules confer resistance to DNA damage-induced apoptosis in cancer cells. 相似文献
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Lee JW Lee SM Hong EJ Jeung EB Kang HY Kim MK Choi IG 《Journal of microbiology (Seoul, Korea)》2006,44(2):177-184
The characteristic biodegradation of monomeric styrene by Phanerochaete chrysosporium KFRI 20742, Trametes versicolor KFRI 20251 and Daldinia concentrica KFRI 40-1 was carried out to examine the resistance, its degradation efficiency and metabolites analysis. The estrogenic reduction effect of styrene by the fungi was also evaluated. The mycelium growth of fungi differentiated depending on the concentration levels of styrene. Additionally P. chrysosporium KFRI 20742 showed superior mycelium growth at less than 200 mg/l, while D. concentrica KFRI 40-1 was more than 200 mg/l. The degradation efficiency reached 99% during one day of incubation for all the fungi. Both manganese-dependent peroxidase and laccase activities in liquid medium were the highest at the initial stage of incubation, whereas the lowest was after the addition of styrene. However, both activities were gradually recovered after. The major metabolites of styrene by P. chrysosporium KFRI 20742 were 2-phenyl ethanol, benzoic acid, cyclohexadiene-1,4-dione, butanol and succinic acid. From one to seven days of incubating the fungi, the expression of pS2 mRNA widely known as an estrogen response gene was decreased down to the level of baseline after one day. Also, the estrogenic effect of styrene completely disappeared after treatment with supernatant of P. chrysosporium KFRI 20742 from one week of culture down to the levels of vehicle. 相似文献
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Hiroshi Fukamachi Hyang Sook Seol Shu Shimada Chikako Funasaka Kanako Baba Ji Hun Kim Young Soo Park Mi Jeung Kim Keiji Kato Mikito Inokuchi Hiroshi Kawachi Jeong Hwan Yook Yoshinobu Eishi Kazuyuki Kojima Woo Ho Kim Se Jin Jang Yasuhito Yuasa 《PloS one》2013,8(8)
Identification of gastric tumor-initiating cells (TICs) is essential to explore new therapies for gastric cancer patients. There are reports that gastric TICs can be identified using the cell surface marker CD44 and that they form floating spheres in culture, but we could not obtain consistent results with our patient-derived tumor xenograft (PDTX) cells. We thus searched for another marker for gastric TICs, and found that CD49fhigh cells from newly-dissected gastric cancers formed tumors with histological features of parental ones while CD49flow cells did not when subcutaneously injected into immunodeficient mice. These results indicate that CD49f, a subunit of laminin receptors, is a promising marker for human gastric TICs. We established a primary culture system for PDTX cells where only CD49fhigh cells could grow on extracellular matrix (ECM) to form ECM-attaching spheres. When injected into immunodeficient mice, these CD49fhigh sphere cells formed tumors with histological features of parental ones, indicating that only TICs could grow in the culture system. Using this system, we found that some sphere-forming TICs were more resistant than gastric tumor cell lines to chemotherapeutic agents, including doxorubicin, 5-fluorouracil and doxifluridine. There was a patient-dependent difference in the tumorigenicity of sphere-forming TICs and their response to anti-tumor drugs. These results suggest that ECM plays an essential role for the growth of TICs, and that this culture system will be useful to find new drugs targeting gastric TICs. 相似文献