全文获取类型
收费全文 | 83篇 |
免费 | 14篇 |
专业分类
97篇 |
出版年
2022年 | 1篇 |
2021年 | 2篇 |
2018年 | 1篇 |
2016年 | 1篇 |
2014年 | 6篇 |
2013年 | 2篇 |
2012年 | 3篇 |
2011年 | 2篇 |
2010年 | 1篇 |
2009年 | 2篇 |
2008年 | 2篇 |
2007年 | 2篇 |
2006年 | 6篇 |
2005年 | 2篇 |
2004年 | 1篇 |
2003年 | 3篇 |
2002年 | 2篇 |
2001年 | 4篇 |
2000年 | 10篇 |
1999年 | 8篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 6篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1971年 | 2篇 |
1969年 | 1篇 |
1966年 | 1篇 |
1965年 | 1篇 |
1960年 | 1篇 |
1959年 | 1篇 |
1958年 | 1篇 |
1956年 | 1篇 |
1948年 | 1篇 |
1946年 | 1篇 |
1945年 | 1篇 |
1943年 | 1篇 |
1936年 | 2篇 |
1933年 | 1篇 |
1907年 | 1篇 |
排序方式: 共有97条查询结果,搜索用时 0 毫秒
21.
Magdalena Winiarska Kamil Bojarczuk Beata Pyrzynska Jacek Bil Marta Siernicka Michal Dwojak Malgorzata Bobrowicz Nina Miazek Piotr Zapala Agnieszka Zagozdzon Magdalena Krol Aleksandra Syta Paulina Podszywalow-Bartnicka Zofia Pilch Anna Dabrowska-Iwanicka Przemyslaw Juszczynski Dimitar G Efremov Mikolaj Slabicki Thorsten Zenz Aude Le Roy Daniel Olive Tomasz P Rygiel Jeanette HW Leusen Jakub Golab 《MABS-AUSTIN》2014,6(5):1300-1313
22.
Increased longevity, expressed as the number of individuals surviving to older adulthood, represents a key way that Upper Paleolithic Europeans differ from earlier European (Neandertal) populations. Here, we address whether longevity increased as a result of cultural/adaptive change in Upper Paleolithic Europe, or whether it was introduced to Europe as a part of modern human biology. We compare the ratio of older to younger adults (OY ratio) in an early modern human sample associated with the Middle Paleolithic from Western Asia with OY ratios of European Upper Paleolithic moderns and penecontemporary Neandertals from the same region. We also compare these Neandertals to European Neandertals. The difference between the OY ratios of modern humans of the Middle and Upper Paleolithic is large and significant, but there is no significant difference between the Neandertals and early modern humans of Western Asia. Longevity for the West Asian Neandertals is significantly more common than for the European Neandertals. We conclude that the increase in adult survivorship associated with the Upper Paleolithic is not a biological attribute of modern humans, but reflects important cultural adaptations promoting the demographic and material representations of modernity. 相似文献
23.
Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9 下载免费PDF全文
Caspari T Dahlen M Kanter-Smoler G Lindsay HD Hofmann K Papadimitriou K Sunnerhagen P Carr AM 《Molecular and cellular biology》2000,20(4):1254-1262
Hus1 is one of six checkpoint Rad proteins required for all Schizosaccharomyces pombe DNA integrity checkpoints. MYC-tagged Hus1 reveals four discrete forms. The main form, Hus1-B, participates in a protein complex with Rad9 and Rad1, consistent with reports that Rad1-Hus1 immunoprecipitation is dependent on the rad9(+) locus. A small proportion of Hus1-B is intrinsically phosphorylated in undamaged cells and more becomes phosphorylated after irradiation. Hus1-B phosphorylation is not increased in cells blocked in early S phase with hydroxyurea unless exposure is prolonged. The Rad1-Rad9-Hus1-B complex is readily detectable, but upon cofractionation of soluble extracts, the majority of each protein is not present in this complex. Indirect immunofluorescence demonstrates that Hus1 is nuclear and that this localization depends on Rad17. We show that Rad17 defines a distinct protein complex in soluble extracts that is separate from Rad1, Rad9, and Hus1. However, two-hybrid interaction, in vitro association and in vivo overexpression experiments suggest a transient interaction between Rad1 and Rad17. 相似文献
24.
Supramolecular structures of peptide assemblies in membranes by neutron off-plane scattering: method of analysis 总被引:1,自引:1,他引:1 下载免费PDF全文
In a previous paper (Yang et al., Biophys. J. 75:641-645, 1998), we showed a simple, efficient method of recording the diffraction patterns of supramolecular peptide assemblies in membranes where the samples were prepared in the form of oriented multilayers. Here we develop a method of analysis based on the diffraction theory of two-dimensional liquids. Gramicidin was used as a prototype model because its pore structure in membrane in known. At full hydration, the diffraction patterns of alamethicin and magainin are similar to gramicidin except in the scale of q (the momentum transfer of scattering), clearly indicating that both alamethicin and magainin form pores in membranes but of different sizes. When the hydration of the multilayer samples was decreased while the bilayers were still fluid, the in-plane positions of the membrane pores became correlated from one bilayer to the next. We believe that this is a new manifestation of the hydration force. The effect is most prominent in magainin patterns, which are used to demonstrate the method of analysis. When magainin samples were further dehydrated or cooled, the liquid-like diffraction turned into crystal-like patterns. This discovery points to the possibility of investigating the supramolecular structures with high-order diffraction. 相似文献
25.
26.
27.
28.
29.