The Effect of the Lipogenic Inhibitor Cerulenin, on Macrostomal Cell Formation in Tetrahymena vorax

ABSTRACT. Macrostomal cell formation is blocked by the antibiotic cerulenin at levels of 15 μg/ml or higher. Inhibition can be reversed up to 4 h following cerulenin addition by washing and resuspending cells in new, noncerulenin-treated transforming principle. In these latter cases, additional time equal to the time spent in the inhibitor, is needed for cells to reach control values of transformation. Neither the addition of saturated or unsaturated fatty acids, cholesterol added alone or in combination with stearic acid, nor a mixture of lipids extracted from Tetrahymena vorax reversed the cerulenin effect. Radioisotope incorporation data showed while protein synthesis was reduced by the end of 1 h and tetrahymanol synthesis by the end of 2 h, little or no effect of this inhibitor occurred on RNA or fatty acid synthesis during these times. One interpretation of these results is that cerulenin, by preventing first protein synthesis and later tetrahymanol synthesis, interferes with synthesis and formation of membranes required for the microstome to macrostome transition.     

The Flight Behavior of Migrating Birds in Changing Wind Fields: Radar and Visual Analyses

This paper examines the influence of atmospheric structure andmotion (principally winds aloft) on the flight behavior andaltitudinal distribution of migrating songbirds. Bird migrationdata that I gathered using surveillance radars operated by theUnited States National Weather Service and the Federal AviationAdministration and a vertically directed fixed-beam marine radarmounted on a mobile laboratory are analyzed in relation to windsaloft. Migrating birds appear to fly at altitudes where windswill minimize the cost of transport and assist movements inseasonally appropriate directions. When migratory flights occurat altitudes that are higher than usual, a significant correlationexists between the altitude of densest migration and the altitudeof most favorable wind. Lower altitudes may be favored overslightly more favorable winds at much higher altitudes. Radardata on the flight behavior of migrating birds in the vicinityof frontal systems is also examined. The flight strategies ofmigrants (fly over the front, change the direction of flight,or land and terminate the flight) differ depending on seasonand the "thickness" of the front. Recent migration studies thatare related to atmospheric structure and motion are summarizedand related to atmospheric processes operating simultaneouslyat vastly different spatial and temporal scales.