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411.
Teratology and Early Fish Development 总被引:1,自引:0,他引:1
SYNOPSIS. The developing teleost embryo is a highly complexand balanced physico-chemical system in equilibrium with itsenvironment. Even slight alterations of the external aquaticenvironment, or a pathochemical modification of the immediatematernal environment, may lead to developmental modifications.Multiple malformations produced as a result of metabolism ofteratogens and interacting factors are similar to syndromesobtained by hybridization. Modifying factors, although possessingsome specificity as to intracellular targets are nonspecificas to the types of anomalies produced in most instances. Embryonic responses to teratogens occur at various developmentalstages and at different levels of organization, modifying thenormal development. Intracellular molecular syntheses and sensitivemetabolic targets essential for normal development may be blockedor modified, and rates of differentiation and growth affected.Embryo-sensitivity and resistance is related to tolerance leveland regulatory capacity. The terata observed have been correlatedwith molecular mechanisms and disorganization with disruptionsof cellular contacts and translocatory yolk cytoplasmic movements. Causality as it pertains to early teleost aberrant developmentis reviewed, and suggestions for research and an extensive bibliographyof the relevant literature provided. 相似文献
412.
Oxytricha granulifera sp.n. differs from other members of the genus by its subpellicular granules and the strongly shortened dorsal kinety 4. The overall pattern of the morphogenetic events is similar to that known from other Oxytrichidae. However, the oral primordium evolves de novo between the left marginal cirral row and the postoral cirri. The six anlagen of the frontoventral cirri are of different origin. Two anlagen of the proter evolve from parental frontal cirri, two from the opisthe, and one includes basal bodies of the proter and opisthe. Two anlagen of the opisthe evolve from the oral primordium, and three primordia originate from the postoral cirri. Frontal cirrus 1 evolves from the paroral membrane in the proter, and from the oral primordium and the anlagen of the frontoventral cirri in the opisthe. The genus Oxytricha can be subdivided into several groups with regard to the origin of its oral primordium and the development of the frontoventral cirri. The morphogenesis of the dorsal kineties in the Hypotrichida is reviewed. Seven different modes of origin are distinguished. We conclude that morphogenetic features cannot be used in the classification of the Hypotrichida at the generic level, because we have too little information to decide whether special morphogenetic features are important at the generic or species level. 相似文献
413.
ERIK WESTBERG HANS‐HELMUT POPPENDIECK JOACHIM W. KADEREIT 《Biological journal of the Linnean Society. Linnean Society of London》2010,101(3):526-535
Oenanthe conioides is a lower Elbe endemic plant species growing in the freshwater tidal zone around Hamburg (Germany). Its closest relative Oenanthe aquatica is widely distributed in Eurasia and grows in calm and shallow freshwater. The two species differ in habitat requirements but are otherwise sympatrically distributed, suggesting that ecological divergence has to be maintained in the face of gene flow. In the present study, we investigated ecological differentiation and reproductive isolation in these two species. An amplified fragment length polymorphism analysis found clear genetic differentiation between the two species implying reproductive isolation. A reciprocal transplantation experiment including artificial F1 hybrids showed strong selection against immigrants. In the two parental habitats, the non‐native species are less fit than the native species. Hybrids are less fit in the habitat of Oe. aquatica but perform as well as the native species in the habitat of Oe. conioides. We hypothesize that selection against immigrants is the most important component of reproductive isolation between the two species, and that selection against immigrants is the result of exposure to cold and wind in the tidal habitat of Oe. conioides and to herbivory in the habitat of Oe. aquatica. These results are congruent with a role for differential ecological selection in the formation and maintenance of these two species. © 2010 The Linnean Society of London, Biological Journal of the Linnean Society, 2010, 101 , 526–535. 相似文献
414.
OLIVER KRAETKE BURKHARD WIESNER JENNY EICHHORST JENS FURKERT MICHAEL BIENERT MICHAEL BEYERMANN 《Journal of receptor and signal transduction research》2013,33(4-6):251-276
As described previously, receptor dimerization of G protein-coupled receptors may influence signaling, trafficking, and regulation in vivo. Up to now, most studies aiming at the possible role of receptor dimerization in receptor activation and signal transduction are focused on class A GPCRs. In the present work, the dimerization behavior of the corticotropin-releasing factor receptor type 1 (CRF1R), which belongs to class B of GPCRs and plays an important role in coordination of the immune response, stress, and learning behavior, was investigated by using fluorescence resonance energy transfer (FRET). For this purpose, we generated fusion proteins of CRF1R tagged at their C-terminus to a cyan or yellow fluorescent protein, which can be used as a FRET pair. Binding studies verified that the receptor constructs were able to bind their natural ligands in a manner comparable with the wild-type receptor, whereas cAMP accumulation proved the functionality of the constructs. In microscopic studies, a dimerization of the CRF1R was observed, but the addition of either CRF-related agonists or antagonists did not show any dose-related increase of the observed FRET signal, indicating that the dimer-monomer ratio is not changed on addition of ligand. 相似文献
415.
416.
417.
JAN OLOF G. KARLSSON SAMUEL P.S. SVENSSON LENA G.E. MRTENSSON SVANTE
DMAN HANS ELWING K. INGEMAR LUNDSTR
M 《Pigment cell & melanoma research》1994,7(1):61-64
Odor perception within olfactory neuroepithelium and pigment translocation within melanophores both seem to rely on a cAMP-based second messenger system. From studies on cultured frog melanophores, Lerner et al. (Proc. Natl. Acad. Sci. USA 85:261-264, 1988) suggested that some aspect of odor perception may be mediated by a nonspecific mechanism whose signal is transduced by a cAMP-based second messenger system. In the present study, odorants (β-ionone, benzylaldehyde, cineole, cinnamaldehyde, and octanol), which previously have been shown to stimulate formation of cAMP in the olfactory neuroepithelium, were investigated for possible pigment dispersing and cAMP-increasing effects. Pretreatment of fish melanophores with the adenylate cyclase activator forskolin (1 μM) resulted in an approximately 300% increase in cAMP and an almost complete blockage of noradrenaline-induced pigment aggregation. However, none of the tested odorants were able to increase the cAMP level and only cinnaldehyde and β-ionone were found to have any pigment dispersing activity. 相似文献
418.
Abstract. A method is presented for the rapid isolation of eye-colour mutants in anopheline mosquitoes based on their inability to undergo a background-stimulated morphological colour change. For application of this method, larval mosquitoes, whose grandfathers had been mutagenized, were reared in black containers and examined with the naked eye en masse during the third or fourth instar. The vast majority of larvae became dark-coloured; however, rare exceptional pale larvae were observed and examined individually microscopically. Approximately half of the pale types examined were eye-colour mutants. By this method, seven sex-linked mutations in the mosquito Anopheles gambiae s.s. were easily isolated. Additional existing anopheline eye-colour mutants in An. gambiae and An. stephensi were tested and were found to be unable to undergo colour change. Several applications of this simple technique are suggested. 相似文献
419.
420.
1. The mate-locating strategies of Pararge aegeria (L.) males were studied in relation to adult morphology (dorsal wing colour, forewing length, body length and forewing length : body length ratio) and generation.
2. Males locate females either by perching and defending territories, or by patrolling. Individuals were more consistent in their mating strategies than expected by chance.
3. Forewing length : body length ratio was positively correlated with thorax mass : body mass; relatively short-bodied males had relatively heavy thoraxes. Therefore, forewing length : body length ratio was an index of mass allocation.
4. Perching males had higher forewing length : body length ratios and were paler than patrolling males.
5. The higher forewing length : body length ratio was due to the differences in body length and not wing length. Perchers had shorter bodies than patrollers. 相似文献
2. Males locate females either by perching and defending territories, or by patrolling. Individuals were more consistent in their mating strategies than expected by chance.
3. Forewing length : body length ratio was positively correlated with thorax mass : body mass; relatively short-bodied males had relatively heavy thoraxes. Therefore, forewing length : body length ratio was an index of mass allocation.
4. Perching males had higher forewing length : body length ratios and were paler than patrolling males.
5. The higher forewing length : body length ratio was due to the differences in body length and not wing length. Perchers had shorter bodies than patrollers. 相似文献