Effect of cobalt and copper complexes with o-phenanthroline on the respiratory activity of mitochondria]

The effects of cobalt and copper complexes with o-phenantroline on the respiratory activity of mitochondria from pea sprouts and submitochondrial particles from bovine heart and on the oxidative phosphorylation in mitochondria were studied. The catalytic activity of the complexes in several components of the respiratory chain autooxidation reactions was investigated. It was shown that the bis (o-phenantroline) cobalt (II) chloride complex is more active in exidation of NADH. The tris (o-phenantroline) cobolt (III) perchlorate complex stimulates the respiratory activity of mitochondria and submitochondrial particles. Possible localization of the effect of this complex was postulated. The (o-phenantroline) copper chloride complex completely inhibits the succinate-dependent respiration of submitochondrial particles and causes disturbances in oxidative phosphorylation of mitochondria.