全文获取类型
收费全文 | 177篇 |
免费 | 24篇 |
国内免费 | 34篇 |
出版年
2022年 | 3篇 |
2021年 | 4篇 |
2020年 | 5篇 |
2019年 | 10篇 |
2018年 | 6篇 |
2017年 | 5篇 |
2016年 | 3篇 |
2015年 | 6篇 |
2014年 | 13篇 |
2013年 | 15篇 |
2012年 | 19篇 |
2011年 | 22篇 |
2010年 | 23篇 |
2009年 | 22篇 |
2008年 | 27篇 |
2007年 | 10篇 |
2006年 | 6篇 |
2005年 | 8篇 |
2004年 | 6篇 |
2003年 | 3篇 |
2002年 | 2篇 |
2001年 | 3篇 |
2000年 | 1篇 |
1997年 | 1篇 |
1993年 | 3篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 3篇 |
排序方式: 共有235条查询结果,搜索用时 46 毫秒
231.
脑钠肽与急性心肌梗死的研究进展 总被引:1,自引:0,他引:1
脑钠肽是心肌细胞分泌的一种循环激素。左心室的牵张和心室壁张力的增加对BNP的合成和分泌起主要调节作用;心肌缺血也是BNP释放的重要触发因素之一。对BNP水平进行分级能够很好的对急性心肌梗死进行危险分层,对诊断、预后的评估有重要意义。本文就脑钠肽的特性及与心肌梗死的关系做一综述。 相似文献
232.
233.
Da-wei Wang Jun-yi Tang Guo-qing Zhang 《Bioscience, biotechnology, and biochemistry》2020,84(7):1362-1372
ABSTRACT
We recently reported that Rho guanine nucleotide exchange factor 10-like protein (ARHGEF10L) activated Rho GTPases as guanine nucleotide exchange factor to stimulate liver tumorigenesis. The present study continued to explore the effect of ARHGEF10L on the tumorigenic process of gastric cancer. This study detected increased expression of ARHGEF10L in GC tissues compared to peritumoral tissue samples. SGC7901 cells with ARHGEF10L overexpression showed increased cell proliferation, cell migration, and tube-like structure formation abilities, as well as increased expression of GTP-RhoA, ROCK1, and phospho-Ezrin/Radixin/Moesin. ARHGEF10L overexpression downregulated the expression of E-cadherin and upregulated the expression of N-cadherin and Slug, indicating an activation of EMT in the transfected cells. RNA-sequencing assay detected an increased expression of Heat shock 70 kDa protein 6 in the SGC7901 cells overexpressing ARHGEF10L. The above results suggest that ARHGEF10L expression can stimulate gastric tumorigenesis by prompting RhoA-ROCK1-phospho-ERM signaling, inducing EMT and increasing HSPA6 expression. 相似文献
234.
235.
Juan Xu Chen-wei ZhouRui-zhi Wang Lu YangShan-shan Du Feng-ping WangHui Ruan Guo-qing He 《Carbohydrate polymers》2012,87(3):2137-2144
Enzymatic modification of starch was conducted by lipase-coupling esterification with octenyl succinic anhydride (OSA). Parameters affecting the esterification were systematically studied. Products were characterized by Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), X-ray diffraction, differential scanning calorimetry (DSC) and viscosity analysis (VA). Optimum condition for lipase-coupling OSA starch preparation was as follows: starch pretreatment at 65 °C for 15 min, starch concentration 35%, amount of lipase and OSA, 0.6% and 3%, reaction pH, temperature and time, 8.0, 40 °C and 30 min respectively, which resulted in 0.0195 of the degree of substitution and 84.05 ± 2.07% of the reaction efficiency. FT-IR spectroscopy confirmed the formation of OSA starch. SEM and X-ray diffraction showed apparent surface change, but no crystalline change. DSC and VA results indicated the synthesized OSA starch gelatinized rapidly with high viscosity. Attractively, reaction time drastically reduced to 30 min, showing vast potential for scale production of OSA starch. 相似文献