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461.
Cecilia Bergenwald Gunilla Westermark B. Sander 《Cancer immunology, immunotherapy : CII》1997,44(6):335-340
Tumor necrosis factor α (TNFα) is a cytokine, produced by lymphocytes and monocytes, with cytotoxic activity against some
but not all tumor cell lines. Resistance to the cytolytic effects of TNFα has been reported in cell lines with autocrine TNFα
production. The purpose of this study was to investigate whether human primary malignant melanoma and tumor infiltrating lymphocytes
produce TNFα in vivo. Optimal conditions for in situ hybridization for TNFα mRNA in paraffin-embedded tissue were established.
Analysis of 13 primary malignant melanomas and 3 metastatic lesions with different degrees of immunohistochemical TNFα positivity
demonstrated that, in some tumors, both melanoma cells and leukocytes contained TNFα mRNA and protein. These findings demonstrate
variable production of TNFα in primary and metastatic melanoma in vivo.The previously described resistance to TNFα cytolytic
activity may, therefore, be clinically important.
Received: 18 December 1996 / Accepted: 12 June 1997 相似文献
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Inger M Brunborg Caroline Fossum Bjørn Lium Gunilla Blomqvist Elodie Merlot Anne Jørgensen Lena Eliasson-Selling Espen Rimstad Christine M Jonassen Per Wallgren 《Acta veterinaria Scandinavica》2010,52(1):22
Background
Despite that PMWS commonly affects pigs aged eight to sixteen weeks; most studies of PMWS have been conducted during the period before transfer to finishing herds. This study focused on PCV2 load and antibody dynamics in finishing herds with different PMWS status. 相似文献464.
465.
Phylogeny of Syrphidae (Diptera) inferred from combined analysis of molecular and morphological characters 总被引:3,自引:0,他引:3
Gunilla Ståhls Heikki Hippa Graham Rotheray Jyrki Muona Francis Gilbert 《Systematic Entomology》2003,28(4):433-450
Abstract. Syrphidae (Diptera) commonly called hoverflies, includes more than 5000 species world-wide. The aim of this study was to address the systematic position of the disputed elements in the intrafamilial classification of Syrphidae, namely the monophyly of Eristalinae and the placement of Microdontini and Pipizini, as well as the position of particular genera ( Nausigaster , Alipumilio , Spheginobaccha ). Sequence data from nuclear 28S rRNA and mitochondrial COI genes in conjunction with larval and adult morphological characters of fifty-one syrphid taxa were analysed using optimization alignment to explore phylogenetic relationships among included taxa. A species of Platypezidae, Agathomyia unicolor , was used as outgroup, and also including one representative ( Jassidophaga villosa ) of the sister-group of Syrphidae, Pipunculidae. Sensitivity of the data was assessed under six different parameter values. A stability tree summarized the results. Microdontini, including Spheginobaccha , was placed basally, and Pipizini appeared as the sister-group to subfamily Syrphinae. The monophyly of subfamily Eristalinae was supported. The results support at least two independent origins of entomophagy in syrphids, and frequent shifts between larval feeding habitats within the saprophagous eristalines. 相似文献
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Sonia Floris Antonella Fais Rosaria Medda Francesca Pintus Alessandra Piras Amit Kumar Piotr Marek Ku Gunilla Torstensdotter Westermark Benedetta Era 《Journal of enzyme inhibition and medicinal chemistry》2021,36(1):517
Washingtonia filifera seeds have revealed to possess antioxidant properties, butyrylcholinesterase and xanthine oxidase inhibition activities. The literature has indicated a relationship between Alzheimer’s disease (AD) and type-2 diabetes (T2D). Keeping this in mind, we have now evaluated the inhibitory properties of W. filifera seed extracts on α-amylase, α-glucosidase enzyme activity and the Islet Amyloid Polypeptide (IAPP) fibrils formation.Three extracts from seeds of W. filifera were evaluated for their enzyme inhibitory effect and IC50 values were calculated for all the extracts. The inhibition mode was investigated by Lineweaver-Burk plot analysis and the inhibition of IAPP aggregate formation was monitored.W. filifera methanol seed extract appears as the most potent inhibitor of α-amylase, α-glucosidase, and for the IAPP fibril formation.Current findings indicate new potential of this extract that could be used for the identification or development of novel potential agents for T2D and AD. 相似文献
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