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101.
Julia Kuehnert Gunhild Sommer Avery W. Zierk Alena Fedarovich Alexander Brock Dzmitry Fedarovich Tilman Heise 《Nucleic acids research》2015,43(1):581-594
The cellular function of the cancer-associated RNA-binding protein La has been linked to translation of viral and cellular mRNAs. Recently, we have shown that the human La protein stimulates IRES-mediated translation of the cooperative oncogene CCND1 in cervical cancer cells. However, there is little known about the underlying molecular mechanism by which La stimulates CCND1 IRES-mediated translation, and we propose that its RNA chaperone activity is required. Herein, we show that La binds close to the CCND1 start codon and demonstrate that La''s RNA chaperone activity can change the folding of its binding site. We map the RNA chaperone domain (RCD) within the C-terminal region of La in close proximity to a novel AKT phosphorylation site (T389). Phosphorylation at T389 by AKT-1 strongly impairs its RNA chaperone activity. Furthermore, we demonstrate that the RCD as well as T389 is required to stimulate CCND1 IRES-mediated translation in cells. In summary, we provide a model whereby a novel interplay between RNA-binding, RNA chaperoning and AKT phosphorylation of La protein regulates CCND1 IRES-mediated translation. 相似文献
102.
Liu Na Skauge Tormod Landa-Marbán David Hovland Beate Thorbjørnsen Bente Radu Florin Adrian Vik Bartek Florczyk Baumann Thomas Bødtker Gunhild 《Journal of industrial microbiology & biotechnology》2019,46(6):855-868
Journal of Industrial Microbiology & Biotechnology - Biofilm accumulation in porous media can cause pore plugging and change many of the physical properties of porous media. Engineering... 相似文献
103.
Abstract We examined the production of virulence factors of Vibrio cholerae O1 bacteria, and especially compared expression in vitro under near optimal growth conditions with that in vivo during experimental cholera infection. The results show that the in vitro formation of cholera toxin (CT), soluble hemagglutinin (SHA), colonizing pilus TCP, and the biotype associated hemagglutinins FSHA and MSHA, as well as of various cell envelope antigens often rather poorly reflected expression in vivo. For instance, production of CT by vibrios of classical biotype and of TCP by the El Tor biotype were enhanced in vivo, while production of SHA was instead suppressed. Likewise significant differences in cell envelope antigen composition were found between bacteria grown in vivo and in vitro. A more precise definition of the role of different postulated virulence factors in the processes of infection and immunity should include in vivo studies as outlined by this study. 相似文献
104.
Øivind Enger Kjell Arne Hoff Gunhild H. Schei Ian Dundas 《FEMS microbiology letters》1990,74(2-3):215-220
Abstract The possible fate in sea water of the two fish pathogenic bacteria Vibrio anguillarum and Vibrio salmonicida is discussed on the basis of microcosm experiments with these and other copiotrophic bacteria. Recent articles dealing with the survival of fish pathogens are reviewed, and the reported survival capacities are discussed in relation to ecological mechanisms, such as death, and predation, leading to the removal of bacteria from the water column. 相似文献