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301.
Ozturk-Engin Derya Agalar Canan Cag Yasemin Can Fatma Kesmez Balkan Ilker Inanc Karabay Oguz Senbayrak Seniha Çetinkaya Busra Meral Aydın Mehmet Timuçin Tomas Kadir Disci Esra Surmelioglu Ali Alimoglu Orhan Ekinci Ozgur Akın Emrah Köroglu Mehmet Velidedeoglu Mehmet Ankaralı Handan Kocoglu Esra Javadov Mirkhaliq Papilla-Kundaktepe Berrin Oguzoglu Naz Ozmen Erkan Donmez Ramazan Mega Ertunç Aksaray Sebahat Agalar Fatih 《International microbiology》2022,25(4):759-767
International Microbiology - Gallbladder and biliary tract infections are diseases with high mortality rates if they are not treated properly. Microbiological evaluation of perioperatively... 相似文献
302.
Metehan Gümüş Fehmi Çelebi Abdullah Böyük Nesrin Gürsan Fatih Akçay 《Cell biochemistry and function》2010,28(6):515-520
We aimed to investigate the ameliorating effect of dehydroepiandrosterone (DHEA) on the potential hepatocellular damage in experimental obstructive jaundice. Twenty‐four male rabbits in the study were randomly allocated into three groups. In the sham group, the choledochal canal was identified and explored. In the obstructive jaundice and treatment groups, the choledochal canal was ligated. Placebo and DHEA were administered to the obstructive jaundice and treatment groups, respectively. Blood samples were obtained at baseline, and both blood samples and liver tissue samples were obtained by re‐laparotomy performed on day 8. Biochemical parameters were measured in blood samples, and liver samples were histopathologically evaluated. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP) and bilirubin levels were lower in the treatment group than in obstructive jaundice. Mononuclear inflammation in the portal region and hepatocyte degeneration were milder in the treatment group compared to obstructive jaundice group. Fibrosis and necrosis were also recovered by the DHEA treatment. In conclusion, these findings suggested that DHEA may reduce the obstructive jaundice‐induced hepatocellular damage. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
303.
304.
Kocyigit-Kaymakcioglu B Toklu HZ Ikiz S Bagcigil AF Rollas S Ozgur NY Ak S 《Journal of enzyme inhibition and medicinal chemistry》2008,23(4):454-461
Some N-(3,5-di-/1,3,5-trimethylpyrazole-4-yl)-4-substitutedbenzamide derivatives were prepared as possible antiociceptive-antimicrobial agents. New amide derivatives (3-12) were synthesized by reacting 4-amino-3,5-di and 1,3,5-trimethylpyrazoles with 4-substitutedbenzoyl chlorides. Hotplate and tail-immersion tests were used for the determination of the antinociceptive activity. Morphine, was used as a standard test drug. All compounds were administered at a dose of 100 mg/kg ip and some of them had significant antinociceptive activity in both tests. Compound 10 (N-(1,3,5-trimethylpyrazole-4-yl)-4-bromobenzamide), was the most active one in both tests among the compounds. The antinociceptive activity of the compounds 10, 11 (N-(1,3,5-trimethylpyrazole-4-yl)-4-chlorobenzamide), and 12 (N-(1,3,5-trimethylpyrazole-4-yl)-4-fluorobenzamide), started at 30 minutes and continued up to 150 minutes in the hotplate test. Also compounds were tested for their in vitro antimicrobial activity, but exhibited weak antibacterial activity. 相似文献
305.
Yavuz Elif Gunes Hatice Bulut Cisem Harsa Sebnem Yenidunya A. Fazil 《World journal of microbiology & biotechnology》2004,20(6):535-537
The 16S-ITS (internal transcribed spacer) region of the rrn operon was amplified by polymerase chain reaction (PCR). The amplification products were analysed by restriction fragment
length polymorphism (RFLP) using a set of restriction enzymes, AluI, HaeIII, and TaqI. Restriction pattern analyses revealed that TaqI restriction enzyme could clearly differentiate the nine reference strains of Lactobacillus used in the study.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
306.
Sariyar-Akbulut B Salman-Dilgimen A Ceylan S Perk S Denizci AA Kazan D 《Archives of microbiology》2008,189(1):19-26
The emerging need for rapid screening and identification methods for microbiological purposes necessitates the combined uses
of high-tech instruments. In this work, electrospray ionization mass spectrometry was used to visualize the relation of ten
newly isolated moderately halophilic microorganisms, to Halomonas salina DSMZ 5928 and Halomonas halophila DSMZ 4770. The method was based on the global analysis of the metabolites in culture media and is termed as metabolic footprinting.
Since it was not possible to gain insight into the similarities solely based on the visual inspection of the chromatograms,
principal component (PC) analysis was applied on the data. Three PCs alone were able to explain 99% of the information in
the data set. The score plots revealed the relation of the new isolates to the two type strains whereas the loading plots
gave important clues on the significant ions responsible for the observed clustering. Loading plots also indicated inversely
correlated ions that give clues on differing metabolic pathways. The work described here offers a potentially useful way for
preliminary rapid phenotypic characterization of new and closely related isolates and a method for screening of similar microorganisms
for different and valuable secondary metabolites. 相似文献
307.
Uluoglu C Cimen B Ozbey G Karasu C Durakoglugil DB Gunes A Turkozkan N Zengil H 《General physiology and biophysics》2008,27(1):25-31
This study investigated time-dependent variations in the activities of adenosine deaminase (ADA), an adenosine-metabolizing enzyme, and myeloperoxidase (MPO), an oxidation reaction-catalyzing enzyme, in control and streptozotocin (STZ)-induced diabetic rat liver. The animals were sacrificed at six different times of day (1, 5, 9, 13, 17 and 21 hours after lights on - HALO). The hepatic activity of ADA did not change depending on the STZ treatment whereas MPO activity was significantly higher in the diabetics than in the controls. Hepatic ADA activity was dependent on the time of sacrifice with the lowest activity at 21 HALO and the highest activity at 5 HALO. Both enzyme activities failed to show any significant interaction between STZ treatment and time of sacrifice, which means that diabetes does not influence the 24 h pattern of these activities. Since MPO, a heme protein localized in the leukocytes, is involved in the killing of microorganisms, increased MPO activity in diabetic rat liver may reflect leukocyte infiltration secondary to diabetes. A reduction in ADA activity during the dark (activity/feeding) period will presumably lead to high concentrations of adenosine in the liver, possibly contributing to changes in some metabolic processes, such as glycogen turnover and oxygen supply. 相似文献
308.
Gunes S Okten G Kara N Saglam Y Tasdemir HA Kayacik OE Tural S 《Genetic counseling (Geneva, Switzerland)》2008,19(3):261-265
We report an 18-year-old Turkish girl with an 18q- deletion and abnormalities of face, mental and growth retardation, mitral deficiency and hypothyroidism. Mitral deficiency has not been reported in 18q deletion syndrome cases previously. We performed cytogenetic and molecular cytogenetic analysis, and brain MRI. Her karyotype was 46,XX,del(18)(q21.2-->qter). This report compares the symptoms and features of the present patient with previously reported cases with 18q syndrome. 相似文献
309.
Occupational Health and Safety (OHS) is a basis to reduce occupational accidents in an acceptable level, and it covers employee health, safety, and welfare in the workplaces. Hospitals as the largest employer group in healthcare industry in Turkey face major hazards categorized as chemical, biological, physical, ergonomic, and psychosocial risks. Although Turkey demonstrates rapid economic growth, OHS practices have not been fully put into practice, and necessary attention has not been paid to the health industry. For this reason, this paper aims to assess risks for health staff, contribute for planning of health services, and enhance regulations. A case study was carried out in a leading hospital in Turkey using a two-stage fuzzy multi-criteria approach, which provides more consistency in decision-making process and gives an appropriate final rank of hazard types. Fuzzy Analytic Hierarchy Process (FAHP) is used in weighing five risk parameters, which are severity, occurrence, undetectability, sensitivity to maintenance non-execution, and sensitivity to personal protective equipment (PPE) non-utilization. The fuzzy VIKOR (FVIKOR) approach is then applied for prioritization of hazard types in each department of the hospital. On conclusion of the hazard control hierarchy, measures are overtaken for the hazards, and areas open for improvement are presented. 相似文献
310.
For decades, the entire pharmaceutical industry has focused on a limited number of drug targets. Owing to advances in molecular biology and genome technology at the beginning of the 1990s, discovery and isolation of a large number of genes from the human genome became feasible. This triggered a multi billion US dollars investment by both biotechnology and pharmaceutical companies to gain access to and patent as many potential drug targets as possible. Although the combined effort of publicly funded projects and private investments resulted in rapid identification of essentially all genes of the human genome, harnessing this information to enable drug discovery has turned out to be more challenging and time consuming than initially anticipated. 相似文献