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Wen-Yong Guo Carla Lambertini Xiao Guo Xiu-Zhen Li Franziska Eller Hans Brix 《Biological invasions》2016,18(9):2551-2561
The environmental conditions in the new ranges of introduced plant species are often different from the conditions in their native ranges, and invasive plant species have been assumed to adapt to different environmental conditions by rapid ecological evolution in the invasive range after the introduction. Another interpretation of the change in plant traits after their introduction, however, is ecological fitting, which is based on the inherently high phenotypic plasticity of the species rather than on evolution. The Mediterranean haplotype M1 lineage of the wetland grass Phragmites australis was introduced to the coastal wetlands along the Gulf Coast of North America, where it is exposed to a different climate compared to its original range. The climate in the native range is arid or temperate with dry and hot summers, whereas the climate in the introduced range is warmer and has a higher and more uniform precipitation than that in the native range. This warmer and more humid environment is likely to pose different selection pressures to the plants in the introduced range and thus cause rapid evolutionary change and phenotypic differentiation in the introduced range. Here, we compared phenotypic traits of the M1 lineage from the native and introduced ranges in a common garden experiment to study the processes assisting the successful spread in the introduced range. Overall, the native and introduced groups were similar, but we detected a few phenotypic traits that diverged. Ecological fitting could be the fundamental mechanism by which the P. australis M1 lineage survives and spreads in the introduced Gulf Coast region. However, further research is needed to assess how the diverging traits observed in our study in Denmark (lower photosynthetic rates, lower chlorophylls concentration and higher leaf K concentration for the introduced than for the native genotypes) are expressed in the two ranges. 相似文献
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The yellowhammer Emberiza citrinella is a common European bird that sings in dialects that for decades have been distinguished by the existence of one single
element (called a “specific”). In this study we looked into other possibilities for dialect discrimination, measuring 24 different
variables. For the first time, multivariate statistics were used to discriminate dialect in yellowhammer song. Two similar
dialects (XlB and XsB) that are not clearly defined in the literature were studied. Statistics incorporated (1) all variables,
(2) no variables of “specific” elements, and (3) no variables under the influence of these “specific” variables. Multivariate
statistics support dialect discrimination by ear and confirmed that only one element in yellowhammer song characterises dialect.
In addition, we looked for local differences within two dialects and found that one local observation area showed a higher
separation than the other sites (Meck1). However, as yet there is insufficient evidence for the existence of a new subdialect.
The experiments comply with the current laws of the study area. 相似文献
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Evidence suggests that dietary calcium (Ca) and particularly dairy foods may attenuate weight gain and improve symptoms of the metabolic syndrome. The purpose of this study was to determine the effect of different Ca‐enriched dairy protein sources on the prevention of weight gain in Sprague‐Dawley diet‐induced obese (DIO) rats. Twelve week‐old DIO rats were assigned to one of eight ad libitum diets that varied in protein source (casein, whey, or complete dairy), Ca content (0.67 or 2.4%) and energy level (high fat/high sucrose (HFHS); or normal calorie density (NC)). Body composition and response to a meal tolerance test (MTT) were measured. Average daily caloric intake did not differ within normal or high energy density groups. At the end of 8 weeks, the dairy/HFHS/0.67% and 2.4% groups had significantly lower body weight than all other HFHS groups. The dairy/HFHS/0.67% and 2.4% groups also had lower body fat and greater lean mass expressed as a percent (P < 0.05). Homeostatic model assessment of insulin resistance (HOMAIR) was lowest for dairy/HFHS/0.67% and significantly different from whey/HFHS/0.67% and 2.4%. Independent of protein source, high Ca decreased plasma insulin at 30 min in the MTT more so than low Ca (P < 0.05). Hepatic sterol regulatory element–binding protein (SREBP1c) and peroxisome proliferator–activated receptor‐γ (PPARγ) mRNA was downregulated by dairy and whey compared to casein in the HFHS/0.67% diets. Overall, these data suggest that complete dairy improves body composition and insulin sensitivity to a greater extent than whey or casein alone. 相似文献
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Zilbauer M Jenke A Wenzel G Postberg J Heusch A Phillips AD Noble-Jamieson G Torrente F Salvestrini C Heuschkel R Wirth S 《PloS one》2010,5(10):e15389
Background
Human beta-defensins (hBDs) are antimicrobial peptides known to play a major role in intestinal innate host defence. Altered mucosal expression of hBDs has been suggested to be implicated in chronic inflammatory bowel disease pathogenesis. However, little is known about expression of these peptides in children.Methods
Intestinal biopsies were obtained from the duodenum (n = 88), terminal ileum (n = 90) and ascending colon (n = 105) of children with Crohn''s disease (n = 26), ulcerative colitis (n = 11) and healthy controls (n = 16). Quantitative real-time (RT) PCR was performed and absolute mRNA copy numbers analyzed for hBD1-3 as well as inflammatory cytokines IL-8 and TNF-alpha.Results
Significant induction of hBD2 and hBD3 was observed in the inflamed terminal ileum and ascending colon of IBD children. In the ascending colon induction of hBD2 was found to be significantly lower in children with Crohn''s disease compared to ulcerative colitis. A strong correlation was found between inducible defensins hBD2 and 3 and the inflammatory cytokines IL-8 and TNF-alpha, both in the terminal ileum and ascending colon.Conclusion
Our study demonstrates distinct changes in hBD expression throughout the intestinal tract of children with IBD, lending further support for their potential role in disease pathogenesis. 相似文献49.
Eller K Wolf D Huber JM Metz M Mayer G McKenzie AN Maurer M Rosenkranz AR Wolf AM 《Journal of immunology (Baltimore, Md. : 1950)》2011,186(1):83-91
Both mast cells (MCs) and regulatory T cells (Tregs) have gained attention as immunosuppressive cell populations. To investigate a possible interaction, we used the Th1- and Th17-dependent model of nephrotoxic serum nephritis (NTS), in which both MCs and Tregs have been shown to play a protective role. Transfer of wild-type (wt) Tregs into wt recipients almost completely prevents development of NTS and leads to a profound increase of MCs in the renal draining lymph nodes (LNs). By contrast, transfer of wt Tregs into animals deficient in MCs, which are characterized by an exaggerated susceptibility to NTS, no longer exhibited protective effects. Blocking the pleiotropic cytokine IL-9, known to be involved in MC recruitment and proliferation, by means of a mAb in mice receiving Tregs abrogated protection from NTS. Moreover, transfer of IL-9-deficient Tregs also failed to protect from NTS. In the absence of Treg-derived IL-9, MCs fail to accumulate in the LNs, despite the fact that IL-9 deficiency does not alter the general suppressive activity of Tregs. In summary, to our knowledge, we provide the first direct in vivo evidence that the nephroprotective, anti-inflammatory effects of Tregs critically depend on IL-9-mediated attraction of MCs into kidney-draining LNs. 相似文献
50.
Eller MA Koehler RN Kijak GH Eller LA Guwatudde D Marovich MA Michael NL de Souza MS Wabwire-Mangen F Robb ML Currier JR Sandberg JK 《Journal of virology》2011,85(10):4802-4811
Natural killer (NK) cells are important innate effector cells controlled by an array of activating and inhibitory receptors. Some alleles of the inhibitory killer-cell immunoglobulin-like receptor KIR3DL1 in combination with its HLA class I ligand Bw4 have been genetically associated with slower HIV-1 disease progression. Here, we observed that the presence of HLA-B Bw4 was associated with elevated frequencies of KIR3DL1(+) CD56(dim) NK cells in chronically HIV-1-infected individuals from the rural district of Kayunga, Uganda. In contrast, levels of KIR2DL1(+) CD56(dim) NK cells were decreased, and levels of KIR2DL3(+) CD56(dim) NK cells were unchanged in infected subjects carrying their respective HLA-C ligands. Furthermore, the size of the KIR3DL1(+) NK cell subset correlated directly with viral load, and this effect occurred only in HLA-B Bw4(+) patients, suggesting that these cells expand in response to viral replication but may have relatively poor antiviral capacity. In contrast, no association with viral load was present for KIR2DL1(+) and KIR2DL3(+) NK cells. Interestingly, chronic HIV-1 infection was associated with an increased polyfunctional response in the NK cell compartment, and, upon further investigation, KIR3DL1(+) CD56(dim) NK cells exhibited a significantly increased functional response in the patients carrying HLA-B Bw4. These results indicate that chronic HIV-1 infection is associated with increased NK cell polyfunctionality and elevated levels of KIR3DL1(+) NK cells in Ugandans carrying the HLA-B Bw4 motif. 相似文献