全文获取类型
收费全文 | 2786篇 |
免费 | 264篇 |
国内免费 | 1篇 |
专业分类
3051篇 |
出版年
2024年 | 2篇 |
2023年 | 32篇 |
2022年 | 48篇 |
2021年 | 112篇 |
2020年 | 64篇 |
2019年 | 76篇 |
2018年 | 91篇 |
2017年 | 80篇 |
2016年 | 126篇 |
2015年 | 162篇 |
2014年 | 188篇 |
2013年 | 233篇 |
2012年 | 307篇 |
2011年 | 280篇 |
2010年 | 137篇 |
2009年 | 126篇 |
2008年 | 169篇 |
2007年 | 164篇 |
2006年 | 141篇 |
2005年 | 104篇 |
2004年 | 91篇 |
2003年 | 92篇 |
2002年 | 83篇 |
2001年 | 25篇 |
2000年 | 20篇 |
1999年 | 15篇 |
1998年 | 11篇 |
1997年 | 13篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 4篇 |
1991年 | 6篇 |
1990年 | 4篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1967年 | 2篇 |
1965年 | 1篇 |
1956年 | 2篇 |
排序方式: 共有3051条查询结果,搜索用时 0 毫秒
41.
Avadí Angel Hodomihou Nounagnon Richard Amadji Guillaume Lucien Feder Frédéric 《The International Journal of Life Cycle Assessment》2021,26(10):1977-1997
The International Journal of Life Cycle Assessment - The goal of this work is to analyse the environmental impacts across the productive continuum of market gardening in southern Benin, to... 相似文献
42.
Leen Depauw Michael P. Perring Dries Landuyt Sybryn L. Maes Haben Blondeel Emiel De Lombaerde Guntis Brūmelis Jörg Brunet Déborah Closset-Kopp Guillaume Decocq Jan Den Ouden Werner Härdtle Radim Hédl Thilo Heinken Steffi Heinrichs Bogdan Jaroszewicz Martin Kopecký Ilze Liepiņa Martin Macek František Máliš Wolfgang Schmidt Simon M. Smart Karol Ujházy Monika Wulf Kris Verheyen 《应用植被学》2021,24(1):e12532
43.
Guillaume Allorent Ryutaro Tokutsu Thomas Roach Graham Peers Pierre Cardol Jacqueline Girard-Bascou Daphné Seigneurin-Berny Dimitris Petroutsos Marcel Kuntz Cécile Breyton Fabrice Franck Francis-André Wollman Krishna K. Niyogi Anja Krieger-Liszkay Jun Minagawa Giovanni Finazzi 《The Plant cell》2013,25(2):545-557
Absorption of light in excess of the capacity for photosynthetic electron transport is damaging to photosynthetic organisms. Several mechanisms exist to avoid photodamage, which are collectively referred to as nonphotochemical quenching. This term comprises at least two major processes. State transitions (qT) represent changes in the relative antenna sizes of photosystems II and I. High energy quenching (qE) is the increased thermal dissipation of light energy triggered by lumen acidification. To investigate the respective roles of qE and qT in photoprotection, a mutant (npq4 stt7-9) was generated in Chlamydomonas reinhardtii by crossing the state transition–deficient mutant (stt7-9) with a strain having a largely reduced qE capacity (npq4). The comparative phenotypic analysis of the wild type, single mutants, and double mutants reveals that both state transitions and qE are induced by high light. Moreover, the double mutant exhibits an increased photosensitivity with respect to the single mutants and the wild type. Therefore, we suggest that besides qE, state transitions also play a photoprotective role during high light acclimation of the cells, most likely by decreasing hydrogen peroxide production. These results are discussed in terms of the relative photoprotective benefit related to thermal dissipation of excess light and/or to the physical displacement of antennas from photosystem II. 相似文献
44.
Erick Dousset Jean Guillaume Steinberg Marion Faucher Yves Jammes 《Free radical research》2013,47(6):701-704
In healthy humans sustaining static handgrip at 60% of maximal voluntary contraction (MVC) until exhaustion, we measured the venous blood concentration of reduced ascorbic acid (RAA) and thiobarbituric acid reactive substances (TBARS), respectively, used as markers of the post-exercise oxidative stress and lipid peroxidation. Measurements were conducted in normoxemia, then during a 30-min period of hypoxemia (PaO 2 =56 mmHg) produced by inhalation of an hypoxic gas mixture. Compared to normoxemia, hypoxemia did not significantly modify the resting concentrations of TBARS and RAA, and did not affect the consumption of ascorbic acid after 60% MVC but suppressed the post-exercise TBARS increase. We conclude that acute hypoxemia does not modify the production of oxygen free radicals after strenuous static efforts and even seems to attenuate the lipid peroxidation. 相似文献
45.
46.
Marie-Pierre Lézé Pascal Marchand Denis Loquet Manuela Kogler Guillaume Le Baut 《Journal of enzyme inhibition and medicinal chemistry》2013,28(6):549-557
The present study was designed to follow our pharmacomodulation work in the field of non-steroidal aromatase inhibitors. All target compounds 12a–h and 28a–h were tested in vitro for human placental aromatase inhibition, using testosterone or androstenedione as the substrate for the aromatase enzyme and the IC50 and relative potency to aminoglutethimide data are included. A SAR study indicated that 3-[(4-fluorophenyl)(1H-imidazol-1-yl)methyl]-1-ethyl-2-methyl-1H-indole (28?g) was a highly potent and selective aromatase inhibitor with IC50 value of 0.025?μM. 28?g was also a weak inhibitor of androstenedione synthesis. 相似文献
47.
Fabrice Pagniez Hiam Abdala-Valencia Pascal Marchand Marc Le Borgne Guillaume Le Baut Sylvie Robert-Piessard 《Journal of enzyme inhibition and medicinal chemistry》2013,28(3):277-283
Two 3-(α-azolylbenzyl)indoles were evaluated against Leishmania amastigotes. Both compounds proved to be very active against intracellular and axenic amastigotes. The IC50 values of the imidazole derivative, PM17, and the triazole analogue, PM19, against L. mexicana axenic amastigotes, were 4.4 ± 0.1 and 6.4 ± 0.1 μM, respectively. Against intracellular amastigotes, PM17 produced a 66% decrease of leishmanial burden at 1 μM and PM19 had an IC50 of 1.3 μM. In a Balb/c mice model of L. major leishmaniasis, administration of PM17 led to a clear-cut parasite burden reduction: 98.9% in the spleen, 79.0% in the liver and 49.9% in the popliteal node draining the cutaneous lesion. As anticipated, it was brought to the fore that PM17 decreases ergosterol biosynthesis leading to membrane fungal cell alterations. Moreover it was proved that this imidazole antifungal agent induces a parasite burden-correlated decrease in interleukine-4 production both in the splenocyte and the popliteal node of the mouse. 相似文献
48.
49.
Emmanuelle Braud Muriel Duflos Guillaume Le Baut Pierre Renard Bruno Pfeiffer Gordon Tucker 《Journal of enzyme inhibition and medicinal chemistry》2013,28(3):253-257
The synthesis and pharmacological evaluation of new 3-(imidazol-4(5)-ylmethylene)-2,3-dihydrobenzo[b]furan-2-ones 8-10 and 3-(3,5-dimethylpyrrol-2-ylmethylene)-2,3-dihydrobenzo[b]furan-2-one 11, analogues of SU-5416, as potential inhibitors of angiogenesis, are reported. Compounds 8 and 11 were prepared by a Knoevenagel reaction starting from 2-hydroxyphenylacetic acid 2 and 4-formylimidazole 5 or 2-formyl-3,5-dimethylpyrrole 7, followed by acid-catalysed cyclodehydration. For compounds 9 and 10, an alternative method was used; it consisted in carrying out the Knoevenagel reaction with the 2,3-dihydrobenzo[b]furan-2-ones 3 and 4. The antiangiogenic activity of these compounds was evaluated in the three-dimensional in vitro rat aortic rings test at 1 μM. At this concentration, compound 11 induced a decrease of angiogenesis comparable to that observed with SU-5416; the vascular density index at 1 μM of 11 and SU-5416 were 30±10 and 22±4% of control, respectively. 相似文献
50.
Vahan Kepenekian Marie-Thérèse Aloy Nicolas Magné Guillaume Passot Emma Armandy Evelyne Decullier Annie Sayag-Beaujard François-Noël Gilly Olivier Glehen Claire Rodriguez-Lafrasse 《Cell stress & chaperones》2013,18(5):623-630
Despite the strong rationale for combining cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal carcinomatosis, thermotolerance and chemoresistance might result from heat shock protein overexpression. The aim of the present study was thus to determine whether the heat shock protein 27 (Hsp27), a potential factor in resistance to treatment, could have a higher level in serum from patients under this combined therapy. Patients receiving CRS plus HIPEC for peritoneal carcinomatosis (group 1), patients with cancer or a history of cancer undergoing abdominal surgery (group 2), and patients without malignancies undergoing abdominal surgery (group 3) were included. Hsp27 serum levels were determined before and at different times following CRS and HIPEC using enzyme-linked immunosorbent assay. In group 1 (n = 25), the high Hsp27 levels, observed at the end of surgery compared with before (p < 0.0001), decreased during HIPEC, but remained significantly higher than before surgery (p < 0.0005). In groups 2 (n = 11) and 3 (n = 15), surgery did not significantly increase Hsp27 levels. A targeted molecular strategy, inhibiting Hsp27 expression in tumor tissue, could significantly reduce resistance to the combined CRS plus HIPEC treatment. This approach should be further assessed in a clinical phase I trial. 相似文献