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61.
62.
Mihalis N. Mindrinos William H. Petri Vasilis K. Galanopoulos Mary F. Lombard Lukas H. Margaritis 《Development genes and evolution》1980,189(3):187-196
Summary TheDrosophila chorion contains an endogenous peroxidase activity which remains inactive until late stage 14 when it catalyzes the crosslinking of the chorionic proteins. Using explanted follicles developing in vitro, premature, but otherwise normal crosslinking can be induced with hydrogen peroxide and normal crosslinking can be prevented with peroxidase inhibitors. Inhibition or premature activation of the shell peroxidase allows characterization of chorionic filament specific proteins and establishes new criteria for the identification of eggshell components. 相似文献
63.
Luis E. Escobar Sandra Pritzkow Steven N. Winter Daniel A. Grear Megan S. Kirchgessner Ernesto Dominguez‐Villegas Gustavo Machado A. Townsend Peterson Claudio Soto 《Biological reviews of the Cambridge Philosophical Society》2020,95(2):393-408
Prions are misfolded infectious proteins responsible for a group of fatal neurodegenerative diseases termed transmissible spongiform encephalopathy or prion diseases. Chronic Wasting Disease (CWD) is the prion disease with the highest spillover potential, affecting at least seven Cervidae (deer) species. The zoonotic potential of CWD is inconclusive and cannot be ruled out. A risk of infection for other domestic and wildlife species is also plausible. Here, we review the current status of the knowledge with respect to CWD ecology in wildlife. Our current understanding of the geographic distribution of CWD lacks spatial and temporal detail, does not consider the biogeography of infectious diseases, and is largely biased by sampling based on hunters' cooperation and funding available for each region. Limitations of the methods used for data collection suggest that the extent and prevalence of CWD in wildlife is underestimated. If the zoonotic potential of CWD is confirmed in the short term, as suggested by recent results obtained in experimental animal models, there will be limited accurate epidemiological data to inform public health. Research gaps in CWD prion ecology include the need to identify specific biological characteristics of potential CWD reservoir species that better explain susceptibility to spillover, landscape and climate configurations that are suitable for CWD transmission, and the magnitude of sampling bias in our current understanding of CWD distribution and risk. Addressing these research gaps will help anticipate novel areas and species where CWD spillover is expected, which will inform control strategies. From an ecological perspective, control strategies could include assessing restoration of natural predators of CWD reservoirs, ultrasensitive CWD detection in biotic and abiotic reservoirs, and deer density and landscape modification to reduce CWD spread and prevalence. 相似文献
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65.
Sabela Da Silva‐lvarez Jorge Guerra‐Varela Daniel Sobrido‐Camen Ana Quelle Antn Barreiro‐Iglesias Laura Snchez Manuel Collado 《Aging cell》2020,19(1)
Cellular senescence is a stress response that limits the proliferation of damaged cells by establishing a permanent cell cycle arrest. Different stimuli can trigger senescence but excessive production or impaired clearance of these cells can lead to their accumulation during aging with deleterious effects. Despite this potential negative side of cell senescence, its physiological role as a pro‐regenerative and morphogenetic force has emerged recently after the identification of programmed cell senescence during embryogenesis and during wound healing and limb regeneration. Here, we explored the conservation of tissue injury‐induced senescence in a model of complex regeneration, the zebrafish. Fin amputation in adult fish led to the appearance of senescent cells at the site of damage, and their removal impaired tissue regeneration. Despite many conceptual similarities, this tissue repair response is different from developmental senescence. Our results lend support to the notion that cell senescence is a positive response promoting tissue repair and homeostasis. 相似文献
66.
Ingrid S. Garcia Susana A. Teixeira Karine A. Costa Daniele B. D. Marques Gustavo de A. Rodrigues Thaís C. Costa Jos D. Guimares Pamela I. Otto Alysson Saraiva Adriana M. G. Ibelli Maurício E. Canto Haniel C. de Oliveira Mnica C. Ledur Jane de O. Peixoto Simone E. F. Guimares 《Molecular reproduction and development》2020,87(7):819-834
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68.
Federico Machinandiarena Leandro Nakamatsu Gustavo E. Schujman Diego de Mendoza Daniela Albanesi 《Molecular microbiology》2020,114(4):653-663
A key aspect in membrane biogenesis is the coordination of fatty acid to phospholipid synthesis rates. In most bacteria, PlsX is the first enzyme of the phosphatidic acid synthesis pathway, the common precursor of all phospholipids. Previously, we proposed that PlsX is a key regulatory point that synchronizes the fatty acid synthase II with phospholipid synthesis in Bacillus subtilis. However, understanding the basis of such coordination mechanism remained a challenge in Gram-positive bacteria. Here, we show that the inhibition of fatty acid and phospholipid synthesis caused by PlsX depletion leads to the accumulation of long-chain acyl-ACPs, the end products of the fatty acid synthase II. Hydrolysis of the acyl-ACP pool by heterologous expression of a cytosolic thioesterase relieves the inhibition of fatty acid synthesis, indicating that acyl-ACPs are feedback inhibitors of this metabolic route. Unexpectedly, inactivation of PlsX triggers a large increase of malonyl-CoA leading to induction of the fap regulon. This finding discards the hypothesis, proposed for B. subtilis and extended to other Gram-positive bacteria, that acyl-ACPs are feedback inhibitors of the acetyl-CoA carboxylase. Finally, we propose that the continuous production of malonyl-CoA during phospholipid synthesis inhibition provides an additional mechanism for fine-tuning the coupling between phospholipid and fatty acid production in bacteria with FapR regulation. 相似文献
69.
José A. González Raül Triay-Portella Sandra Correia Albertino Martins Gustavo González-Lorenzo José M. Lorenzo José G. Pajuelo 《Zeitschrift fur angewandte Ichthyologie》2021,37(2):350-353
The length–weight relationships (LWR) were estimated for five selected demersal marine fishes from the relatively undisturbed shelves and slopes of the Cabo Verde Islands. Most of them were of ecological and/or commercial interest. Occasional sampling was carried out during different fisheries research projects. LWRs were taken for the following bycatch species for which no such estimates exists in the science literature: Myroconger compressus, Synaphobranchus affinis, Physiculus cyanostrophus, Physiculus caboverdensis and Canthidermis maculata. Total length and fork length (to the nearest 0.1 cm) and total weight (to the nearest 0.1 g) were determined. The resulting length–weight equations are characterized by a high accompanying coefficient of correlation. The present data help improving the knowledge base needed for further fish biology studies and fisheries management. 相似文献
70.
Checchio Mirela Vantini de Cássia Alves Rita de Oliveira Kevein Ruas Moro Gustavo Vitti Santos Durvalina Maria Mathias dos Gratão Priscila Lupino 《Journal of plant research》2021,134(6):1279-1289
Journal of Plant Research - Salinity has become one of the major factors limiting agricultural production. In this regard, different cost-effective management strategies such as the use of plant... 相似文献