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排序方式: 共有298条查询结果,搜索用时 15 毫秒
101.
Andrew MF Liu Rico KH Lo Emily X Guo Maurice KC Ho Richard D Ye Yung H Wong 《BMC structural biology》2011,11(1):17
Background
G protein-coupled receptors constitute the largest family of cell surface receptors in the mammalian genome. As the core of the G protein signal transduction machinery, the Gα subunits are required to interact with multiple partners. The GTP-bound active state of many Gα subunits can bind a multitude of effectors and regulatory proteins. Yet it remains unclear if the different proteins utilize distinct or common structural motifs on the Gα subunit for binding. Using Gα16 as a model, we asked if its recently discovered adaptor protein tetratricopeptide repeat 1 (TPR1) binds to the same region as its canonical effector, phospholipase Cβ (PLCβ). 相似文献102.
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Hermann Grote 《Journal of Ornithology》1920,68(2):124-156
Ohne Zusammenfassung
Schlufs von S. 70. 相似文献
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Hermann Grote 《Journal of Ornithology》1921,69(3):406-408
Ohne Zusammenfassung 相似文献
107.
A covariance structure model for the admixture of binary genetic variation 总被引:1,自引:0,他引:1 下载免费PDF全文
Grote MN 《Genetics》2007,176(4):2405-2420
I derive a covariance structure model for pairwise linkage disequilibrium (LD) between binary markers in a recently admixed population and use a generalized least-squares method to fit the model to two different data sets. Both linked and unlinked marker pairs are incorporated in the model. Under the model, a pairwise LD matrix is decomposed into two component matrices, one containing LD attributable to admixture, and another containing, in an aggregate form, LD specific to the populations forming the mixture. I use population genetics theory to show that the latter matrix has block-diagonal structure. For the data sets considered here, I show that the number of source populations can be determined by statistical inference on the canonical correlations of the sample LD matrix. 相似文献
108.
David J Sewell Richard Turner Ray Field William Holmes Rahul Pradhan Christopher Spencer Stephen G Oliver Nigel KH Slater Duygu Dikicioglu 《Biotechnology and bioengineering》2019,116(6):1315-1325
Without a scale-down model for perfusion, high resource demand makes cell line screening or process development challenging, therefore, potentially successful cell lines or perfusion processes are unrealized and their ability untapped. We present here the refunctioning of a high-capacity microscale system that is typically used in fed-batch process development to allow perfusion operation utilizing in situ gravity settling and automated sampling. In this low resource setting, which involved routine perturbations in mixing, pH and dissolved oxygen concentrations, the specific productivity and the maximum cell concentration were higher than 3.0 × 106 mg/cell/day and 7 × 10 7 cells/ml, respectively, across replicate microscale perfusion runs conducted at one vessel volume exchange per day. A comparative analysis was conducted at bench scale with vessels operated in perfusion mode utilizing a cell retention device. Neither specific productivity nor product quality indicated by product aggregation (6%) was significantly different across scales 19 days after inoculation, thus demonstrating this setup to be a suitable and reliable platform for evaluating the performance of cell lines and the effect of process parameters, relevant to perfusion mode of culturing. 相似文献
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Bryndan P. Durham Jana Grote Kerry A. Whittaker Sara J. Bender Haiwei Luo Sharon L. Grim Julia M. Brown John R. Casey Antony Dron Lennin Florez-Leiva Andreas Krupke Catherine M. Luria Aric H. Mine Olivia D. Nigro Santhiska Pather Agathe Talarmin Emma K. Wear Thomas S. Weber Jesse M. Wilson Matthew J. Church Edward F. DeLong David M. Karl Grieg F. Steward John M. Eppley Nikos C. Kyrpides Stephan Schuster Michael S. Rappé 《Standards in genomic sciences》2014,9(3):632-645
Strain HIMB11 is a planktonic marine bacterium isolated from coastal seawater in Kaneohe Bay, Oahu, Hawaii belonging to the ubiquitous and versatile Roseobacter clade of the alphaproteobacterial family Rhodobacteraceae. Here we describe the preliminary characteristics of strain HIMB11, including annotation of the draft genome sequence and comparative genomic analysis with other members of the Roseobacter lineage. The 3,098,747 bp draft genome is arranged in 34 contigs and contains 3,183 protein-coding genes and 54 RNA genes. Phylogenomic and 16S rRNA gene analyses indicate that HIMB11 represents a unique sublineage within the Roseobacter clade. Comparison with other publicly available genome sequences from members of the Roseobacter lineage reveals that strain HIMB11 has the genomic potential to utilize a wide variety of energy sources (e.g. organic matter, reduced inorganic sulfur, light, carbon monoxide), while possessing a reduced number of substrate transporters. 相似文献