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91.
Galoyan AA Sarkissian JS Sulkhanyan RM Chavushyan VA Avetisyan ZA Avakyan ZE Gevorgyan AJ Abrahamyan DO Grigorian YKh 《Neurochemical research》2005,30(4):487-505
We investigated the action of the new hypothalamic proline-rich peptide (PRP-1), normally produced by neurosecretory cells of hypothalamic nuclei (NPV and NSO), 3 and 4 weeks following rat sciatic nerve transection. The impulse activity flow of interneurons (IN) and motoneurons (MN) on stimulation of mixed (n. ischiadicus), flexor (n. gastrocnemius – G) and extensor (n. peroneus communis – P) nerves of both injured and symmetric intact sides of spinal cord (SC) was recorded in rats with daily administration of PRP-1 (for a period of 3 weeks) and without it (control). On the injured side of SC in control, there were no responses of IN and MN on ipsilateral G and P stimulation, while responses were elicited on contralateral nerve stimulation. The neuron responses on the intact side of SC were revealed in a reverse ratio. Thus, there were no effects upon stimulation of the injured nerve distal stump in the control because of the absence of fusion between transected nerve stumps. This was also testified by the atrophy of the distal stump and the absence of motor activity of the affected limb. In PRP-1-treated animals, the responses of SC IN and MN in postaxotomy 3 weeks on the injured side of SC at ipsilateral nerve stimulation and on the intact side at contralateral nerve stimulation were recorded because of the obvious fusion of the severed nerve stumps. The histochemical data confirmed the electrophysiological findings. Complete coalescence of transected fibers together with restoration of the motor activity of the affected limb provided evidence for reinnervation on the injured side. Thus, it may be concluded that PRP-1 promotes nerve regeneration and may be used clinically to improve the outcome of peripheral nerve primary repair. 相似文献
92.
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94.
G E Grigorian A M Stol'berg 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1989,39(2):259-266
Behaviour of the rats, previously learnt to come back to one and the same place of reinforcement was studied in conditions of periodical changes of this place. It was found that after detection of the new place of reinforcement, the rats could optimize their behaviour according to disposition of this place. Optimization of behaviour consisted in shifts of running direction towards the new reinforcement place and (or) in selective displacements before blinds, according to the places of reinforcement in the experiment. It is suggested that an increase of the role of working memory and apparatus of probabilistic prognosis at choice lies in the basis of optimization. 相似文献
95.
Restriction map of the temperate phage E105 from the polylysogenic culture of Erwinia carotovora 268
Iu A Grigorian F I Tovkach V V Danile?chenko Ia G Kishko 《Molekuliarnaia genetika, mikrobiologiia i virusologiia》1988,(3):24-27
DNA structure of the temperate bacteriophage E105 from polylysogenic culture of Erwinia carotovora 268 has been studied. The viral 29.12-29.17 MD DNA has been shown to be linear and nonpermuted. The complete restriction map of the viral DNA has been constructed for MvaI and HpaI and partial for Eco31 restriction endonucleases based on the pair hydrolysis of the native DNA as well as its fragments. Altogether, 19 sites for restriction endonucleases have been localized on bacteriophage DNA. 相似文献
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97.
In sheep from biogeochemical provinces enriched by molybdenum and copper and in a model form of molybdenum toxicosis in animals, the important role of enzymic and neurohumoral systems in the development of adaptation to excessive uptake of molybdenum and copper has been demonstrated. Adaptive reorganization of the activity of enzymic systems (xanthine oxidase, ceruloplasmin, succinate dehydrogenase, aspartate and alanine aminotransferases) and gradual involvement of neurohumoral mechanisms of the sympathoadrenal and cholinoreactive systems provide for adaptation of some animals in molybdenum and copper-molybdenum biogeochemical provinces. In other sheep, under the same conditions, dystonic disturbances in the vegetative nervous systems are observed together with the development of molybdenum toxicosis. 相似文献
98.
G E Grigorian A M Stol'berg 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1991,41(4):717-723
Comparison of rats behaviour with different preliminary experience in elaboration of the strategy of return to place of reinforcement was conducted. Significant differences in the number of selective replacements to the place of reinforcement in previous tests in experienced, inexperienced and naive rats were found. It was proved that decisive role in the appearance of the found differences played gained experience and the process of engram extraction from memory. Inhibition of search in naive rats and ability to selective use of strategies corresponding to situation in the experienced ones in condition of stress of permanent changes were shown. 相似文献
99.
Some characteristics of olfactory behaviour of albino rats in three-arm maze have been studied. It was found that the olfactory discrimination of different food reinforcements may be elaborated in passages as long as 90 cm. Choice reactions were determined by olfactory, not visual, stimuli on their simultaneous presentation. 相似文献
100.
The formation of carbonitride (C x N y ) films in the active and afterglow phases of a glow discharge in CH4-N2 mixtures (as well in these mixtures diluted with argon and helium) was studied experimentally. The dependences of the film growth rate on the discharge current and gas pressure are obtained. The composition (the N/C ratio) and IR absorption spectra of the films are determined. Measurements of the absorption spectra made it possible to identify bonds between C and N atoms. A novel method of carbonitride film deposition in the “double afterglow” mode was proposed. The use of this method appreciably increases the film deposition rate. Possible mechanisms of the formation and destruction of carbonitride films in the active and afterglow phases of the discharge are discussed. 相似文献