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501.
502.
P. M. Guyre Robert F. Graziano Joel Goldstein Paul K. Wallace Peter M. Morganelli Kathleen Wardwell Alexandra L. Howell 《Cancer immunology, immunotherapy : CII》1997,45(3-4):146-148
A major challenge for using native and modified T cell epitopes to induce or suppress immunity relates to achieving efficient
uptake and processing by antigen-presenting cells (APC) in vivo. IgG Fc receptors, which are expressed constitutively by professional
APC including monocytes and dendritic cells, have long been known to mediate antigen uptake in a manner leading to efficient
T cell activation. We have previously demonstrated enhanced presentation of antigenic and antagonistic peptides by targeting
them to the type I Fc receptor for IgG (FcγRI, CD64) on human monocytes. In the present report we review the literature suggesting
that CD64-targeted antigens are likely to be effective in vivo, and present data demonstrating enhanced immunogenicity in
CD64 transgenic mice of a fusion protein that combines the specificities of HIV gp120 and the humanized anti-CD64 monoclonal
antibody H22. Overall, these studies suggest that targeting antigens to CD64 represents an effective approach to enhancing
the effectiveness of vaccines in vivo.
Accepted: 14 October 1997 相似文献
503.
Isabella Barajon Graziano Serrao Francesca Arnaboldi Emanuela Opizzi Gerlomina Ripamonti Andrea Balsari Cristiano Rumio 《The journal of histochemistry and cytochemistry》2009,57(11):1013-1023
The aim of the present study was to evaluate the expression of innate immunity receptors belonging to the Toll-like family in the neural plexuses of the different tracts of murine intestine, of the human ileum, and in lower dorsal root ganglia (DRGs) from where extrinsic afferents to these plexuses originate. Results obtained by immunohistochemistry and immunofluorescence on paraffin-embedded tissue and whole-mount preparations show that Toll-like receptors (TLRs) -3 and -7, recognizing viral RNA, and TLR4, recognizing lipopolysaccharide (membrane component of Gram-negative bacteria), are expressed in the myenteric and submucous plexuses of murine intestine and human ileum, and in DRGs primary sensory neurons. They also show that TLR4 immunostaining is stronger in murine distal large bowel. In murine tissue, expression of TLRs was present in both neurons and glial cells. These observations indicate that the enteric neural network might be directly activated by bacterial and viral components and is therefore more in the forefront than previously envisaged in defense responses of the intestinal wall and in the cross-talk with intestinal microbiota. They also highlight the presence of a peripheral neural network that by way of hardwired neurotransmission could potentially convey to the central nervous system specific information on our microbial counterpart and invading or potentially invading pathogens. (J Histochem Cytochem 57:1013–1023, 2009) 相似文献
504.