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Evolutionary correlation between control region sequence and restriction polymorphisms in the mitochondrial genome of a large Senegalese Mandenka sample 总被引:25,自引:2,他引:23
Graven L; Passarino G; Semino O; Boursot P; Santachiara-Benerecetti S; Langaney A; Excoffier L 《Molecular biology and evolution》1995,12(2):334-345
We present here the first comparative analysis at the population level
between Restriction Fragment Length Polymorphism (RFLP) and control region
sequence polymorphism in a large and homogeneous Senegalese Mandenka
sample. Eleven RFLP haplotypes and 60 different sequences are found in 119
individuals, revealing that a very high level of mtDNA diversity can be
maintained in a small population. A sequence neighbor- joining tree and an
analysis of molecular variance show that sequences associated with a given
restriction haplotype are evolutionarily highly correlated: sequencing
generally leads to the subtyping of RFLP haplotypes. Evolutionary
relationships among RFLP haplotypes inferred from restriction site
differences are in good agreement with those inferred from sequence data. A
single difference is observed and is likely due to a single restriction
homoplasy having occurred in the control region. Selective neutrality tests
on both RFLP and sequence data accept the hypotheses of mtDNA neutrality
and population equilibrium. The deep coalescence times (exceeding 50,000
yr) of sequences associated with the two most frequent restriction
haplotypes confirm that the Niokolo Mandenka population has not passed
through a recent bottleneck and that gene flow is maintained among West
African populations despite ethnic differences.
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22.
Anette Graven Sams Gitte Kobberøe Mikkelsen Mogens Larsen Lars Torup Lise Tøttrup Brennum Tenna Juul Schrøder Benny Bang-Andersen 《Bioorganic & medicinal chemistry letters》2010,20(17):5241-5244
Herein we describe the discovery of a series of novel adenosine A2A receptor antagonists. A successful hit-to-lead optimization of an HTS hit led to replacement of a metabolically labile ester moiety with a heteroaromatic group. A compound from the series, (cyclopropanecarboxylic acid [5-(5-methyl-[1,2,4]oxadiazol-3-yl)-4-phenyl-thiazol-2-yl]-amide, compound 13), was shown to be effective in reversing haloperidol-induced hypolocomotion, a model of motor dysfunction in Parkinson’s Disease. 相似文献
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