全文获取类型
收费全文 | 183篇 |
免费 | 13篇 |
国内免费 | 9篇 |
出版年
2015年 | 12篇 |
2014年 | 12篇 |
2013年 | 12篇 |
2012年 | 7篇 |
2011年 | 13篇 |
2010年 | 8篇 |
2009年 | 9篇 |
2008年 | 3篇 |
2007年 | 7篇 |
2006年 | 10篇 |
2005年 | 2篇 |
2004年 | 6篇 |
2003年 | 5篇 |
2002年 | 2篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 9篇 |
1997年 | 7篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 7篇 |
1988年 | 2篇 |
1986年 | 2篇 |
1982年 | 2篇 |
1977年 | 2篇 |
1955年 | 1篇 |
1954年 | 2篇 |
1952年 | 1篇 |
1934年 | 1篇 |
1929年 | 1篇 |
1925年 | 1篇 |
1924年 | 1篇 |
1921年 | 1篇 |
1919年 | 1篇 |
1918年 | 1篇 |
1916年 | 1篇 |
1915年 | 1篇 |
1910年 | 2篇 |
1908年 | 1篇 |
1907年 | 1篇 |
1905年 | 2篇 |
1904年 | 1篇 |
1903年 | 3篇 |
1900年 | 1篇 |
1899年 | 7篇 |
1898年 | 1篇 |
1888年 | 1篇 |
1882年 | 3篇 |
1879年 | 1篇 |
排序方式: 共有205条查询结果,搜索用时 15 毫秒
101.
102.
103.
Dawn M. Cooper David J. Granville Carl Lowenberger 《Apoptosis : an international journal on programmed cell death》2009,14(3):247-256
Developmental and tissue homeostasis is a delicate balance between cell proliferation and cell death. The activation of caspases,
a conserved family of cysteine proteases, is a main event in the initiation and execution of programmed cell death. While
caspases have been characterized from many organisms, comparatively little is known about insect caspases. In Drosophila melanogaster, seven caspases have been characterized; three initiators and four effectors. In mosquitoes, several putative caspases have
been identified in the genomes of Aedes aegypti and Anopheles gambiae. A small number of caspases have been identified in the Lepidoptera, the flour beetle, Tribolium castaneum, and the pea aphid, Acyrthosiphon pisum. The availability of new insect genome sequences will provide a unique opportunity to examine the caspase family across an
evolutionarily diverse phylum and will provide valuable insights into their function and regulation. 相似文献
104.
105.
CA Lei- CHEN Run-Zheng- YIN Zhi-Jian- ZHANG Guo-Xue- CHEN Wen-Hong- SHUI Yu-Min 《Plant Diversity》2015,37(6):733-736
A new species of Gesneriaceae from Honghe County, Southeastern Yunnan, China, Tremacron hongheense WH. Chen & YM. Shui, is described and illustrated. The new species is similar to Tremacron forrestii Craib, but differs by its leaf blade adaxially sparsely long setose (vs. densely white appressed pubescent and sparsely rusty brown villous), corolla tube outside short white glandular (vs. nearly glabrous), corolla lobes red and thickening at apex, especially adaxial lip (vs. yellow and not thickening), stamens 16-18cm long (vs. 04-12cm long), staminode 05-14cm long (vs. 02-04cm long). 相似文献
106.
Grasslands are one of the most widespread landscapes worldwide, covering approximately one-fifth of the world’s land surface, where grazing is a common practice. How carbon storage responds to grazing in steppes remains poorly understood. We quantified the effects of grazing on community composition and species diversity, and carbon storage in two typical grasslands of northeastern China, one in Horqin and the other one in Hulunbeier. In both grasslands, grazing did not influence plant species diversity. However, it substantially decreased aboveground carbon by 31% and 54% in Horqin and Hulunbeier, respectively. Fenced and grazing treatments showed a similar belowground carbon at both locations. The predominant carbon pool in the study grassland ecosystem was found in the upper 100 cm soil depth, from 98.2 to 99.1% of the total carbon storage. There were no significant effects of grazing on soil carbon neither in the whole profile nor in the uppermost 20 cm soil depth in the two study grasslands. Studies on the effects of varying rangeland management, such as region disparity and grazing systems, may have important consequences on species diversity and carbon partitioning, and thus on rangeland stability and ecosystem functioning. 相似文献
107.
108.
Craig J Smith Hedley CA Emsley Carole M Gavin Rachel F Georgiou Andy Vail Elisa M Barberan Gregory J del Zoppo John M Hallenbeck Nancy J Rothwell Stephen J Hopkins Pippa J Tyrrell 《BMC neurology》2004,4(1):1-8
Background
Cerebral ischaemia initiates an inflammatory response in the brain and periphery. We assessed the relationship between peak values of plasma interleukin-6 (IL-6) in the first week after ischaemic stroke, with measures of stroke severity and outcome.Methods
Thirty-seven patients with ischaemic stroke were prospectively recruited. Plasma IL-6, and other markers of peripheral inflammation, were measured at pre-determined timepoints in the first week after stroke onset. Primary analyses were the association between peak plasma IL-6 concentration with both modified Rankin score (mRS) at 3 months and computed tomography (CT) brain infarct volume.Results
Peak plasma IL-6 concentration correlated significantly (p < 0.001) with CT brain infarct volume (r = 0.75) and mRS at 3 months (r = 0.72). It correlated similarly with clinical outcome at 12 months or stroke severity. Strong associations were also noted between either peak plasma C-reactive protein (CRP) concentration or white blood cell (WBC) count, and all outcome measures.Conclusions
These data provide evidence that the magnitude of the peripheral inflammatory response is related to the severity of acute ischaemic stroke, and clinical outcome. 相似文献109.
Germana B Rona Natalia P Almeida Gilson C Santos Jr Tatiana KS Fidalgo Fabio CL Almeida Elis CA Eleutherio Anderson S Pinheiro 《Journal of cellular biochemistry》2019,120(4):5377-5385
NSD3s, the proline-tryptophan-tryptophan-proline (PWWP) domain-containing, short isoform of the human oncoprotein NSD3, displays high transforming properties. Overexpression of human NSD3s or the yeast protein Pdp3 in Saccharomyces cerevisiae induces similar metabolic changes, including increased growth rate and sensitivity to oxidative stress, accompanied by decreased oxygen consumption. Here, we set out to elucidate the biochemical pathways leading to the observed metabolic phenotype by analyzing the alterations in yeast metabolome in response to NSD3s or Pdp3 overexpression using 1H nuclear magnetic resonance (NMR) metabolomics. We observed an increase in aspartate and alanine, together with a decrease in arginine levels, on overexpression of NSD3s or Pdp3, suggesting an increase in the rate of glutaminolysis. In addition, certain metabolites, including glutamate, valine, and phosphocholine were either NSD3s or Pdp3 specific, indicating that additional metabolic pathways are adapted in a protein-dependent manner. The observation that certain metabolic pathways are differentially regulated by NSD3s and Pdp3 suggests that, despite the structural similarity between their PWWP domains, the two proteins act by unique mechanisms and may recruit different downstream signaling complexes. This study establishes for the first time a functional link between the human oncoprotein NSD3s and cancer metabolic reprogramming. 相似文献
110.
The role of Granzyme B in atheromatous diseases 总被引:1,自引:0,他引:1