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排序方式: 共有429条查询结果,搜索用时 46 毫秒
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Five antioxidative agents (BW755C, 1-naphtol, NDGA, propylgallate and quercetin) were compared with indomethacin and ETYA for their effects on (14C) arachidonic acid metabolism by cyclooxygenase (CO) and lipoxygenase (LPO) enzymes in intact human platelets. All tested compounds inhibited CO activity in a concentration-dependent manner. LPO activity was suppressed by NDGA, propylgallate, quercetin and ETYA but strongly enhanced by BW755C, 1-napthol and indomethacin. Whereas NDGA and ETYA showed almost equipotent inhibitory effects towards both fatty acid oxygenases, propylgallate and quercetin were found to be respectively 6.5 and 4 times better inhibitors of LPO than of CO activities.These data indicate that antioxidants affect arachidonic acid metabolism in intact human platelets in different ways: BW755C and 1-naphtol exerted the same activity as indomethacin, a selective CO blocker, whereas NDGA, propylgallate and quercetin behaved as ETYA, a dual CO-LPO inhibitor. Considering their inhibition selectivity, propylgallate and quercetin may serve as prototypes for more specific blockers of LPO activity. 相似文献
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Summary Electron microscopic investigation of neural isolated and normal pars ventralis of the tuber cinereum showed the presence, in Rana temporaria, of a tubero-hypophysial neurosecretory system. A striking structural resemblance between this parvicellular, aldehydefuchsin negative, tubero-hypophysial neurosecretory system and the magnocellular, aldehydefuchsin positive, hypothalamo-hypophysial neurosecretory system was observed. Six different neurosecretory cell types are described, characterized by different shape and size of their respective secretory granules. The nature of the secretory product of these cells is briefly discussed.Of the results of this investigation, a preliminary note has been published (Dierickx, 1971).The authors wish to thank Prof. Dr. H. Steyaert and Dr. W. Moerdijk of the Laboratory for Mathematical Statistics, Ghent University, for invaluable advice and assistance with their computers. They thank Dr. G. De Waele for his help with the scanning electron microscopy. 相似文献
426.
Goossens Yanne Berrens Paulien Custers Kristof Van Hemelryck Steven Kellens Karel Geeraerd Annemie 《The International Journal of Life Cycle Assessment》2019,24(4):688-693
The International Journal of Life Cycle Assessment - After publishing the abovementioned article in the “Online First Articles” list, an error was discovered. 相似文献
427.
Régis Millet Laurence Goossens Karine Bertrand-Caumont Raymond Houssin Benoît Rigo Jean-François Goossens Jean-Pierre Hénichart 《Letters in Peptide Science》2000,7(5):269-279
New chemical entities were designed from the C-terminal sequence of GR71251, an NK1 pseudopeptide antagonist. Three new NK1 antagonists were identified with high affinity and selectivity for NK1 receptors. 相似文献
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G Contrafatto G K Campbell P J Taylor V Goossens K Willan J A Meester 《Cytogenetics and cell genetics》1992,60(1):45-47
Results of chromosome G- and C-banding studies on 12 specimens of the ice rat, Otomys sloggetti robertsi, from three localities and allozyme analyses of seven individuals from two localities are reported. The subspecies karyotype contains 42, mostly acrocentric, chromosomes. No chromosomal variation was detected among animals from these localities. Allozyme analysis tentatively suggested a limited gene flow between the two populations examined. 相似文献
429.
Veronique van den Berghe Elke Stappers Bram Vandesande Jordane Dimidschstein Roel Kroes Annick Francis Andrea Conidi Flore Lesage Ruben Dries Silvia Cazzola Geert Berx Nicoletta Kessaris Pierre Vanderhaeghen Wilfred van IJcken Frank G. Grosveld Steven Goossens Jody J. Haigh Gord Fishell Eve Seuntjens 《Neuron》2013,77(1):70-82