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161.
Killer activity expressed at pH values ranging from 3.5 to 6.0 was found in the ustilaginaceous yeast-like species, Pseudozyma tsukubaensis. Its killer phenotype was incurable, and extrachromosomal genetic elements were not detected. The toxin excreted with a molecular
mass above 15 kDa is fungicidal, resistant to proteolytic cleavage, thermolabile and active only against fungi within the
Ustilaginomycetes (the orders Microstromatales and Ustilaginales). 相似文献
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Golubeva EK Nazarov SB Kazak MV 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2004,90(9):1151-1155
Influence of acute hemorrhage on peritoneal and splenic macrophages function and NO production was studied. Interaction of peritoneal and splenic macrophages with autologous erythrocytes was examined the day after the hemorrhage. Concentration of nitrate ions: the stable metabolites of nitric oxide, was measured in peritoneal lavage, splenic cells suspension, blood, as well as in supernatant of peritoneal and splenic macrophages before and after hemorrhage. The data obtained suggest that splenic macrophages of intact rats are more active than peritoneal ones. After hemorrhage peritoneal macrophages activity increases, whereas splenic macrophages remain unchanged. Concentration of nitrate ions is significantly reduced after hemorrhage. 相似文献
165.
Nosikov AN Chichikalo EV Golubeva LI Zvyagilskaya RA L'vov NP 《Biochemistry. Biokhimii?a》2000,65(2):204-207
Tungsten in the presence of molybdenum stimulates nitrate reductase activity and growth of the salt-tolerant yeast Rhodotorula glutinis on medium with nitrates. Tungsten is not incorporated in proteins possessing nitrate reductase activity. A significant increase in molybdenum cofactor in cells grown on medium with equimolar amounts of molybdenum and tungsten may relate to the stimulatory action of tungsten. 相似文献
166.
Kostanian IA Zhokhov SS Astapova MV Dranitsyna SM Bogachuk AP Baĭdakova LK Rodionov IL Baskin II Golubeva ON Tombran-Tink J Lipkin VM 《Bioorganicheskaia khimiia》2000,26(8):563-570
It was shown that the full-size neurotrophic factor from pigment epithelium (PEDF) induces the cell differentiation of the human promyelocyte leukemia cell line HL-60. A structural analysis of PEDF revealed in its C-terminal region a six-membered peptide fragment PEDF-(352-357) (PEDF-6) whose sequence is highly homologous to the 41-46 fragment of the active site of the human leukocyte differentiation factor HLDF (HLDF-6). The biological effect of PEDF and synthetic peptides PEDF-6 and HLDF-6 on the HL-60 cells and the early gastrula ectoderm of Xenopus laevis embryos was studied. On the basis of the structural and functional homologies of HLDF, PEDF, and their homologous peptides and the computer models of the spatial structures of the full-size PEDF and the PEDF with the C-terminal fragment split off tby the cleavage of the Leu380-Thr381 bond in the serpin loop, a hypothesis on the functional role of the serpin loop in PEDF was put forward. 相似文献
167.
EB Adamah-Biassi Y Zhang H Jung S Vissapragada RJ Miller ML Dubocovich 《The journal of histochemistry and cytochemistry》2014,62(1):70-84
The pineal hormone melatonin activates two G-protein coupled receptors (MT1 and MT2) to regulate in part biological functions. The MT1 and MT2 melatonin receptors are heterogeneously distributed in the mammalian brain including humans. In the mouse, only a few reports have assessed the expression of the MT1 melatonin receptor expression using 2-iodomelatonin binding, in situ hybridization and/or polymerase chain reaction (PCR). Here, we described a transgenic mouse in which red fluorescence protein (RFP) is expressed under the control of the endogenous MT1 promoter, by inserting RFP cDNA at the start codon of MTNR1a gene within a bacterial artificial chromosome (BAC) and expressing this construct as a transgene. The expression of RFP in the brain of this mouse was examined either directly under a fluorescent microscope or immunohistochemically using an antibody against RFP (RFP-MT1). RFP-MT1 expression was observed in many brain regions including the subcommissural organ, parts of the ependyma lining the lateral and third ventricles, the aqueduct, the hippocampus, the cerebellum, the pars tuberalis, the habenula and the habenula commissure. This RFP-MT1 transgenic model provides a unique tool for studying the distribution of the MT1 receptor in the brain of mice, its cell-specific expression and its function in vivo. 相似文献
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Pregnancy block in mice requires exposure of recently mated females to
urinary pheromones of a strange male, and when working with inbred strains
this invariably requires urine from an outbred line. The pheromones which
induce oestrus and early puberty in mice have been identified as the
brevicomins and dihydrothiazoles. Since the same vomeronasal, neural and
neuroendocrine pathways are also activated in pregnancy block, these
compounds are likely candidates for pregnancy blocking pheromones. However,
these relatively simple chemicals lack the capacity to code for differing
mouse strains. Since large quantities of the polymorphic major urinary
proteins from the lipocalin family found in urine serve as transporters for
the dihydrothiazoles and brevicomins, and differ across strains, then these
proteins must participate in pheromone recognition in the context of
pregnancy block.
相似文献