全文获取类型
收费全文 | 156篇 |
免费 | 5篇 |
专业分类
161篇 |
出版年
2019年 | 1篇 |
2015年 | 2篇 |
2014年 | 1篇 |
2013年 | 6篇 |
2012年 | 13篇 |
2011年 | 8篇 |
2010年 | 8篇 |
2009年 | 6篇 |
2008年 | 6篇 |
2007年 | 11篇 |
2006年 | 8篇 |
2005年 | 11篇 |
2004年 | 5篇 |
2003年 | 6篇 |
2002年 | 7篇 |
2001年 | 5篇 |
2000年 | 8篇 |
1999年 | 3篇 |
1996年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 5篇 |
1986年 | 2篇 |
1985年 | 4篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1980年 | 1篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1973年 | 2篇 |
1971年 | 2篇 |
1970年 | 2篇 |
1968年 | 1篇 |
1965年 | 1篇 |
1963年 | 1篇 |
1962年 | 1篇 |
1957年 | 1篇 |
排序方式: 共有161条查询结果,搜索用时 15 毫秒
81.
Liu XP Goldring CE Copple IM Wang HY Wei W Kitteringham NR Park BK 《Life sciences》2007,80(17):1586-1591
The standard extract of Ginkgo biloba (EGb) has been demonstrated to possess remarkable antioxidant activity in both cell lines and animals. However, the molecular mechanism underlying this effect is not fully understood. Phase 2 enzymes play important roles in the antioxidant system by reducing electrophiles and reactive oxygen species (ROS). We demonstrated that EGb induced typical phase 2 genes: glutamate cysteine ligase catalytic subunit (GCLC) and glutathione-S-transferase subunit-P1 (GST-P1), by real-time PCR. To investigate the molecular mechanism of this induction, we used quinone oxidoreductase 1 (NQO1) -- Antioxidant response element (ARE) reporter assay and found that EGb activated the activity of the wild type but not the one with ARE mutated. It indicated that EGb induced these genes through ARE, a cis-acting motif located in the promoter region of nearly all phase 2 genes. Since nuclear factor erythroid 2-related factor 2 (Nrf2) binds ARE to enhance the expression of phase 2 genes, we detected the Nrf2 content in nucleus and found an accumulation of Nrf2 stimulated by EGb. In a further test of Kelch-like ECH-associated protein 1 (Keap1), the repression protein of Nrf2 in the cytosol under resting condition, we found that Keap1 content was inhibited by EGb and then more Nrf2 would be released to translocate into nucleus. Thus, EGb was testified for the first time to induce the phase 2 genes through the Keap1-Nrf2-ARE signaling pathway, which is (or part of) the antioxidant mechanism of EGb. 相似文献
82.
83.
Shen Z Crotti TN Flannery MR Matsuzaki K Goldring SR McHugh KP 《Biochimica et biophysica acta》2007,1769(11-12):659-667
84.
85.
The control of chondrogenesis 总被引:19,自引:0,他引:19
86.
Formerly known as a hypoendemic malaria country, the Republic of Djibouti declared the goal of pre-eliminating malaria in 2006. The aim of the present study was to evaluate the prevalence of Plasmodium falciparum, Plasmodium vivax and mixed infections in the Djiboutian population by using serological tools and to identify potential determinants of the disease and hotspots of malaria transmission within the country. The prevalence of P. falciparum and P. vivax within the districts of the capital city and the rest of the Republic of Djibouti were assessed using 13 and 2 serological markers, respectively. The relationship between the immune humeral response to P. falciparum and P. vivax and variables such as age, gender, wealth status, urbanism, educational level, distance to rivers/lakes, living area, having fever in the last month, and staying in a malaria-endemic country more than one year was estimated and analysed by questionnaires administered to 1910 Djiboutians. Multivariate ordinal logistic regression models of the immune humeral response were obtained for P. falciparum and P. vivax. The P. falciparum and P. vivax seroprevalence rates were 31.5%, CI95% [29.4-33.7] and 17.5%, CI95% [15.8-19.3], respectively. Protective effects against P. falciparum and P. vivax were female gender, educational level, and never having visited a malaria-endemic area for more than one year. For P. falciparum only, a protective effect was observed for not having a fever in the last month, living more than 1.5 km away from lakes and rivers, and younger ages. This is the first study that assessed the seroprevalence of P. vivax in the Republic of Djibouti. It is necessary to improve knowledge of this pathogen in order to create an effective elimination programme. As supported by recent observations on the subject, the Republic of Djibouti has probably demonstrated a real decrease in the transmission of P. falciparum in the past seven years, which should encourage authorities to improve efforts toward elimination. 相似文献
87.
Goldring A. Zamir D. Degani Ch. 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1985,71(3):491-494
Summary Avocado (Persea americana) cultivars were assayed for phosphoglucose isomerase (PGI) isozymes using starch gel electrophoresis. Three PGI genes were identified: one monomorphic locus, Pgi-I, coding for the plastid isozyme and two independently assorting loci, Pgi-2 and Pgi-3, coding for the cytosolic isozymes. The genetic analysis was based on comparisons of PGI zymograms from somatic and pollen tissue and on Mendelian analysis of progeny from selfed trees. The isozymic variability for PGI can be used for cultivar identification and for differentiating between hybrid and selfed progeny in avocado breeding. 相似文献
88.
Yeang HX Hamdam JM Al-Huseini LM Sethu S Djouhri L Walsh J Kitteringham N Park BK Goldring CE Sathish JG 《The Journal of biological chemistry》2012,287(13):10556-10564
89.
90.
Fernando M. Botelho Carla M. T. Bauer Donna Finch Jake K. Nikota Caleb C. J. Zavitz Ashling Kelly Kristen N. Lambert Sian Piper Martyn L. Foster James J. P. Goldring Jadwiga A. Wedzicha Jennifer Bassett Jonathan Bramson Yoichiro Iwakura Matthew Sleeman Roland Kolbeck Anthony J. Coyle Alison A. Humbles Martin R. St?mpfli 《PloS one》2011,6(12)