排序方式: 共有128条查询结果,搜索用时 15 毫秒
41.
42.
43.
Ertan T Yildiz I Ozkan S Temiz-Arpaci O Kaynak F Yalcin I Aki-Sener E Abbasoglu U 《Bioorganic & medicinal chemistry》2007,15(5):2032-2044
A new series of N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamide and phenylacetamide derivatives (1a-1n, 2a-2n) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and their drug-resistant isolate. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 500 and 1.95 microg/ml. Benzamide derivative 1d exhibited the greatest activity with MIC values of 1.95, 3.9, and 7.8 microg/ml against drug-resistant B. subtilis, B. subtilis, and S. aureus, respectively. 相似文献
44.
Hashmi Muneeb Hassan Saeed Faisal Demirel Ufuk Bakhsh Allah 《In vitro cellular & developmental biology. Plant》2022,58(6):1066-1076
In Vitro Cellular & Developmental Biology - Plant - A simple and improved Agrobacterium-mediated transformation protocol of tomato (Solanum lycopersicum) cultivar Rio Grande was developed to... 相似文献
45.
The objective of the present study was to investigate gene expression pattern of two docetaxel resistant MCF-7 breast carcinoma sublines step wisely selected in 30 and 120 nM docetaxel. Cell proliferation assay was performed in order to demonstrate development of docetaxel resistance. cDNA microarray analysis was performed using Affymetrix® Human Genome U133 Plus 2.0 Arrays in duplicate experiments. Quantitative and semi-quantitative gene expression analysis was also performed to confirm gene expression analysis for selected genes. XTT results demonstrated that 30 (MCF-7/30nM DOC) and 120 nM (MCF-7/120nM DOC) docetaxel selected cells were 13- and 47-fold resistant, respectively. cDNA microarray analysis demonstrated that expression profiles of MCF-7 and MCF-7/30nM DOC were more similar to each other where expression profile of MCF-7/120nM DOC was different as examined by line graphs and scatter plots. 2,837 and 4,036 genes were significantly altered in 30 and 120 nM docetaxel resistant sublines, respectively. Among these, 849 genes were altered in common in two docetaxel resistant sublines. Antiapoptotic gene expression (e.g., Bcl-2 and APRIL) were noticeably altered in MCF-7/30nM DOC. However, docetaxel resistance in MCF-7/120nM DOC were more complicated with the involvement of ECM related gene expression, cytokine and growth factor signaling, ROS metabolism and EMT related gene expression together with higher level of MDR1 expression. Expression profiles in 30 and 120 nM docetaxel resistant sublines changed gradually with increasing resistance index. Drug resistance development seems to be step wise event in MCF-7 cells. 相似文献
46.
Olgac U Kurtcuoglu V Poulikakos D 《American journal of physiology. Heart and circulatory physiology》2008,294(2):H909-H919
The work herein represents a novel approach for the modeling of low-density lipoprotein (LDL) transport from the artery lumen into the arterial wall, taking into account the effects of local wall shear stress (WSS) on the endothelial cell layer and its pathways of volume and solute flux. We have simulated LDL transport in an axisymmetric representation of a stenosed coronary artery, where the endothelium is represented by a three-pore model that takes into account the contributions of the vesicular pathway, normal junctions, and leaky junctions also employing the local WSS to yield the overall volume and solute flux. The fraction of leaky junctions is calculated as a function of the local WSS based on published experimental data and is used in conjunction with the pore theory to determine the transport properties of this pathway. We have found elevated levels of solute flux at low shear stress regions because of the presence of a larger number of leaky junctions compared with high shear stress regions. Accordingly, we were able to observe high LDL concentrations in the arterial wall in these low shear stress regions despite increased filtration velocity, indicating that the increase in filtration velocity is not sufficient for the convective removal of LDL. 相似文献
47.
Carbonic Anhydrase and Urease Inhibitory Potential of Various Plant Phenolics Using in vitro and in silico Methods
下载免费PDF全文
![点击此处可从《化学与生物多样性》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Abdur Rauf Muslim Raza Muhammad Saleem Ufuk Ozgen Esen Sezen Karaoglan Gulin Renda Erhan Palaska Ilkay Erdogan Orhan 《化学与生物多样性》2017,14(6)
Plant phenolics are known to display many pharmacological activities. In the current study, eight phenolic compounds, e.g., luteolin 5‐O‐β‐glucoside ( 1 ), methyl rosmarinate ( 2 ), apigenin ( 3 ), vicenin 2 ( 4 ), lithospermic acid ( 5 ), soyasaponin II ( 6 ), rubiadin 3‐O‐β‐primeveroside ( 7 ), and 4‐(β‐d ‐glucopyranosyloxy)benzyl 3,4‐dihydroxybenzoate ( 8 ), isolated from various plant species were tested at 0.2 mm against carbonic anhydrase‐II (CA‐II) and urease using microtiter assays. Urease inhibition rate for compounds 1 – 8 ranged between 5.0 – 41.7%, while only compounds 1 , 2 , and 4 showed a considerable inhibition over 50% against CA‐II with the IC50 values of 73.5 ± 1.05, 39.5 ± 1.14, and 104.5 ± 2.50 μm , respectively, where IC50 of the reference (acetazolamide) was 21.0 ± 0.12 μm . In silico experiments were also performed through two docking softwares (Autodock Vina and i‐GEMDOCK) in order to find out interactions between the compounds and CA‐II. Actually, compounds 6 (30.0%) and 7 (42.0%) possessed a better binding capability toward the active site of CA‐II. According to our results obtained in this study, among the phenolic compounds screened, particularly 1 , 2 , and 4 appear to be the promising inhibitors of CA‐II and may be further investigated as possible leads for diuretic, anti‐glaucoma, and antiepileptic agents. 相似文献
48.
Type 2 Diabetes Inhibited Human Mesenchymal Stem Cells Angiogenic Response by Over‐Activity of the Autophagic Pathway
下载免费PDF全文
![点击此处可从《Journal of cellular biochemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
49.
Influence of the activated sludge system configuration on heavy metal toxicity reduction 总被引:1,自引:0,他引:1
Ufuk Alkan Sevil Çalışkan Eleren Berrak Erol Nalbur Elif Odabaş 《World journal of microbiology & biotechnology》2008,24(8):1435-1443
The effect of configuration of activated sludge systems on heavy metal toxicity was investigated. Two bench-scale completely
mixed activated sludge systems were operated identically in order to determine the toxic effects of Cr(VI), Zn(II) and industrial
wastewater on the activated sludge biomass. One system was operated with an aerobic selector and the other without. Batch
experiments based on OECD 209 (Organisation for Economic Cooperation and Development) were performed using a respirometer
to find out potential toxicity reduction effect of an aerobic selector. The IC50 (concentration of a chemical that exhibits 50% respiration inhibition) values of Cr(VI), Zn(II) and industrial wastewater
in the activated sludge were determined. Results indicated that the heavy metals and industrial wastewater caused less inhibitory
effect on the selector activated sludge system in comparison to the conventional activated sludge system. Cr(VI) was found
to exert higher inhibition on both systems. 相似文献
50.
Öztürk Gökçe Zahide Neslihan Aksoy Emre Bakhsh Allah Demirel Ufuk Çalışkan Sevgi Çalışkan Mehmet Emin 《Functional & integrative genomics》2021,21(3-4):489-502
Functional & Integrative Genomics - MicroRNAs are small, non-coding RNAs that are responsible for regulation of gene expression during plant growth and development. Although there are many... 相似文献