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361.
362.
Godwin Bökel 《Plant Systematics and Evolution》1855,5(13):101-102
Ohne Zusammenfassung 相似文献
363.
Godwin Pancras Mangi Ezekiel David Nderitu Bege Dauda Erasto Vitus Mbugi 《Developing world bioethics》2023,23(3):220-228
Debates about what constitutes benefits in human research continue to be less informed due to a lack of empirical evidence from the developing world. This study aimed to explore what constitutes benefits in HIV vaccine trials in Tanzania and examine inherent ethical implications. A qualitative case study design was deployed and a total of 29 purposively selected study participants comprising of experienced researchers, institutional review board members and community advisory board members were included. Collected data were analyzed by thematic analysis aided by computer software: MAXQDA version 20.4.0. The study findings indicate that there is a growing appreciation of benefits beyond actual vaccines to include 1) capacity building at individual, community, institutional and regulatory levels; and 2) non-capacity building related benefits such as strengthened collaborations, ancillary care and employment opportunities. So, as the struggle for viable HIV vaccines continues, other benefits that have accrued from such trials are not to be blindsided especially for developing countries like Tanzania. 相似文献
364.
Godwin I. Adoga 《Bioscience reports》1986,6(10):909-912
The effect on glutathione reductase activities of feeding garlic oil to white albino rats maintained on high sucrose and alcohol diets was studied. Whereas high sucrose and alcohol diets resulted in significant increases in the activity of glutathione reductase in liver, kidneys and serum, the presence of garlic oil restored the levels to near normal. It is proposed that the mechanism of this action of garlic oil involves the active principle, diallyl disulphide, which interacts in an exchange reaction with enzymes and substrates such as glutathione reductase and glutathione which contain thiol groups. 相似文献
365.
M. Ira Thabrew Godwin O. Emerole 《Biochimica et Biophysica Acta (BBA)/General Subjects》1983,756(2):242-246
trans-Stilbene oxide (400 mg/kg) produced a 500% increase in the microsomal in the microsomal epoxide hydratase activity in rat and mouse with little change in the soluble enzyme activity. However, in guinea pig, the soluble epoxide hydratase activity increased by about 33% with only a small increase (47.6%) in the microsomal enzyme activity. The soluble glutathione S-transferase activities were also induced in both rat and mouse, with little change in that of the guinea pig. Increasing dosage of trans-stilbene oxide from 400 mg/kg to 1000 mg/kg had little effect on the above enzyme activities. That the guinea pig was not relatively refractory to all inducing agents was shown by the fact phenobarbital (100 mg/kg) and 3-methylcholanthrene (25 mg/kg) produced relatively similar increases in the activities of aniline hydroxylase and P-aminopyrineP-demethylase in rat, mouse and guinea pig. However, these inducers produced only a 15–20% stimulation in the soluble glutathione S-transferase and microsomal epoxide hydratase activities in guinea pig, when compared to a 50–80% increase in rat and mouse, suggesting a general resistance to induction by the phase II enzymes in guinea liver. In all animal models, the inducer markedly increased th emicrosomal total phospholipid content, although the sphingomyelin content itself was decreased. In both rat and mouse, the microsomal cholesterol content was significantly decreased while that in guinea pig was unaffected. Possible factors responsible for the observed species differences are discussed. 相似文献
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Ryan T. Godwin 《Biometrical journal. Biometrische Zeitschrift》2019,61(6):1541-1556
The one‐inflated positive Poisson mixture model (OIPPMM) is presented, for use as the truncated count model in Horvitz–Thompson estimation of an unknown population size. The OIPPMM offers a way to address two important features of some capture–recapture data: one‐inflation and unobserved heterogeneity. The OIPPMM provides markedly different results than some other popular estimators, and these other estimators can appear to be quite biased, or utterly fail due to the boundary problem, when the OIPPMM is the true data‐generating process. In addition, the OIPPMM provides a solution to the boundary problem, by labelling any mixture components on the boundary instead as one‐inflation. 相似文献
369.
Seth D. Judson Matthew LeBreton Trevon Fuller Risa M. Hoffman Kevin Njabo Timothy F. Brewer Elsa Dibongue Joseph Diffo Jean-Marc Feussom Kameni Severin Loul Godwin W. Nchinda Richard Njouom Julius Nwobegahay Jean Michel Takuo Judith N. Torimiro Abel Wade Thomas B. Smith 《EcoHealth》2018,15(1):52-62
Recent outbreaks of Ebola virus disease and Zika virus disease highlight the need for disseminating accurate predictions of emerging zoonotic viruses to national governments for disease surveillance and response. Although there are published maps for many emerging zoonotic viruses, it is unknown if there is agreement among different models or if they are concordant with national expert opinion. Therefore, we reviewed existing predictions for five high priority emerging zoonotic viruses with national experts in Cameroon to investigate these issues and determine how to make predictions more useful for national policymakers. Predictive maps relied primarily on environmental parameters and species distribution models. Rift Valley fever virus and Crimean-Congo hemorrhagic fever virus predictions differed from national expert opinion, potentially because of local livestock movements. Our findings reveal that involving national experts could elicit additional data to improve predictions of emerging pathogens as well as help repackage predictions for policymakers. 相似文献
370.