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Reactive oxygen species (ROS) are of great importance in plant metabolism. However, uncontrolled activation of ROS might have deleterious effects in cells. Eleven Mediterranean countries are still under threat of an introduced taxon of Caulerpa racemosa var. cylindracea. In the present study, it has been aimed to compare the antioxidant status of this highly invasive alga with some Mediterranean macrophytes collected in the same habitat. For this purpose, such antioxidant enzyme activities as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and lipid peroxidation (LPO) as well, levels have been determined in C. racemosa, Cystoseira barbata C. Agardh, Padina pavonica (Linnaeus) Thivy and Enteromorpha sp. The highest SOD, CAT, GSH-Px enzyme activities and the lowest LPO level have been measured in the invasive C. racemosa. In conclusion, C. racemosa var. cylindracea seems more tolerant in warring with ROS than the Mediterranean species tested do. These results could partly explain the amazing success of C. racemosa var. cylindracea introduced in the Mediterranean. 相似文献
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Dagdelen Duriye Nur Akkulak Aysenur Donmez Yalcin Gizem 《Molecular biology reports》2021,48(4):3495-3502
Molecular Biology Reports - Glioblastoma multiform is a primary brain tumor derived from glial cells. The aim of this study is to investigate how glutamate metabolism is regulated by glutamate... 相似文献
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Gizem Kursunluoglu Hulya Ayar Kayali Dilek Taskiran 《Cell biochemistry and biophysics》2014,69(3):707-716
Cisplatin accumulates in mitochondria, which is a potent and widely used chemotherapeutic agent. In order to clarify the potential effect of cisplatin on electron transport chain (ETC), the variation of succinate dehydrogenase (SDH) and cytochrome c oxidase (COX) enzyme activities, nucleotide levels, as well as catalase (CAT) enzyme and membrane lipid peroxidation (LPO) level with respect to liver and kidney of cisplatin-exposed rats were studied. We found that cisplatin caused significant impairment in the SDH, COX, and CAT activities, and nucleotide levels associated with membrane LPO in isolated mitochondria. It was determined whether capsaicin, as an antioxidant, has a possible protective role on all investigated parameters of liver and kidney induced by cisplatin. The results of capsaicin + cisplatin suggest that capsaicin have antioxidant capacity to scavenge ROS to prevent membrane damage. 相似文献
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Andrew Fairbairn Fikri Kulakoğlu Levent Atici 《Vegetation History and Archaeobotany》2014,23(2):167-174
Archaeobotanical samples from the Middle Bronze Age (MBA; c. 2000–1700 b.c.) city of Kanesh, excavated at the site of Kültepe in Kayseri Province, Turkey, preserve the charred shells of hazelnut (Corylus sp.). Hazelnut species do not naturally grow in the Kayseri area, being a native element of the broadleaf woodlands of Turkey’s Black Sea region, today home to a multi-million dollar international hazelnut export industry. The finds come from both the upper and lower city, being restricted to the Middle Bronze Age Karum level II, an occupation phase which saw the greatest development of the Assyrian trade network of which Kanesh was the administrative centre. This archaeobotanical discovery at Kültepe provides the earliest direct evidence for trade in hazelnuts in the region, probably imported on a small scale as luxury items facilitated by the Assyrian trade network. It also provides independent support for historical claims that hazelnut was traded at Kanesh based on the analysis of cuneiform tablets. 相似文献
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Nontyphoid salmonella (NTS) serotypes can cause gastroenteritis, bacteriemia, and focal infections. However, these focal infections, including urinary tract infections (UTI), are occasionally observed; in particular, the presence of several predisposing factors, such as immunodeficiency and structural abnormality in the urinary tract, increase the possibility of the occurrence of infection. We present a case of UTI caused by Salmonella enterica serovar Virchow in an elderly and debilitated patient with benign prostatic hyperplasia (BPH). Administration of appropriate antibiotic treatment resulted in recovery of the patient's clinical course. 相似文献
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Tepeli E Caner V Büyükpınarbaşılı N Çetin GO Düzcan F Elmas L Bağcı G 《Molecular biology reports》2012,39(1):335-341
Excision Repair Cross-Complementing Group 1 (ERCC1) is an important DNA repair gene, playing critical role in nucleotide excision repair pathway and having a significant influence
on genomic instability. Some studies support that ERCC1 might be a potential predictive and prognostic marker in non-small cell lung cancer (NSCLC). ERCC1 has also been shown to be a promising biomarker in NSCLC treated with a cisplatin-based regimen. Therefore, the determination
of ERCC1 expression at DNA, mRNA and protein level in different stages of NSCLC is still an important topic in the cancer.
Ninety-one formalin-fixed paraffin-embedded tumor samples histopathologically diagnosed as NSCLC were examined in this study.
ERCC1 expression at protein level were scored by immunohistochemistry. The gene amplification and mRNA expression levels for
ERCC1 were determined by real-time quantitative PCR. There was complete concordance among the three methods in 39 tumor samples
(42.9%). A strong correlation was found between DNA amplification and mRNA expression (r = 0.662) while there was no correlation between mRNA and protein assessment for ERCC1 expression (r = −0.013). ERCC1 expression at mRNA and DNA level (63.1 and 84.2%, respectively) in tumors at stage III was higher than at
the other stages. In contrast, the protein expression at stage II and III (56.6 and 52.6%, respectively) of NSCLC was lower
than that of tumors with stage I NSCLC. These results show that the mechanism by which ERCC1 expression might play a role
in tumor behavior. This study was also confirmed that the appropriate validation and qualification in methods used for ERCC1
status were needed before its clinical application and implementation. 相似文献
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