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661.
Winters Gidon Otieno Dennis Cohen Shabtai Bogner Christina Ragowloski Gideon Paudel Indira Klein Tamir 《Oecologia》2018,188(3):695-705
Oecologia - Drought-induced tree mortality has been recently increasing and is expected to increase further under warming climate. Conversely, tree species that survive under arid conditions might... 相似文献
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Pedro W. Crous Orlando Petrini Gideon F. Marais Zaccharia A. Pretorius Franziska Rehder 《Mycoscience》1995,36(1):105-111
Fungal endophytes were isolated from leaves, roots and stems of four wheat cultivars and a breeding line at three different sampling dates during the 1993 growing season. Of the 55 different fungal taxa encountered, 19 were present at relative importance values of more than 5%. No cultivar-related differences in the assembleges of endophytes were observed.Phoma glomerata was not restricted to only one tissue type, whereasAlternaria alternata, basidiomycete sp. 1,Pleospora herbarum andEpicoccum nigrum occurred primarily in the leaves, andFusarium avenaceum was extremely frequent in roots. In general, colonization by endophytes increased with the age of the plants. Most endophytes were isolated from wheat leaves. Successional colonization of a given tissue type was quantitative rather than qualitative, with a given fungal taxon increasing or decreasing over the period sampled, rather than replacing the fungi initially encountered.Present address: Téra d'Sott 5, CH-6949, Comano, Switzerland. 相似文献
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Kelath Murali Manoj Daniel A. Gideon Nikolai M. Bazhin Hirohisa Tamagawa Vijay Nirusimhan Mahendra Kavdia Laurent Jaeken 《Journal of cellular physiology》2023,238(1):109-136
The redox metabolic paradigm of murburn concept advocates that diffusible reactive species (DRS, particularly oxygen-centric radicals) are mainstays of physiology, and not mere pathological manifestations. The murburn purview of cellular function also integrates the essential principles of bioenergetics, thermogenesis, homeostasis, electrophysiology, and coherence. In this context, any enzyme that generates/modulates/utilizes/sustains DRS functionality is called a murzyme. We have demonstrated that several water-soluble (peroxidases, lactate dehydrogenase, hemogoblin, etc.) and membrane-embedded (Complexes I–V in mitochondria, Photosystems I/II in chloroplasts, rhodopsin/transducin in rod cells, etc.) proteins serve as murzymes. The membrane protein of Na,K-ATPase (NKA, also known as sodium-potassium pump) is the focus of this article, owing to its centrality in neuro-cardio-musculo electrophysiology. Herein, via a series of critical queries starting from the geometric/spatio-temporal considerations of diffusion/mass transfer of solutes in cells to an update on structural/distributional features of NKA in diverse cellular systems, and from various mechanistic aspects of ion-transport (thermodynamics, osmoregulation, evolutionary dictates, etc.) to assays/explanations of inhibitory principles like cardiotonic steroids (CTS), we first highlight some unresolved problems in the field. Thereafter, we propose and apply a minimalist murburn model of trans-membrane ion-differentiation by NKA to address the physiological inhibitory effects of trans-dermal peptide, lithium ion, volatile anesthetics, confirmed interfacial DRS + proton modulators like nitrophenolics and unsaturated fatty acid, and the diverse classes of molecules like CTS, arginine, oximes, etc. These explanations find a pan-systemic connectivity with the inhibitions/uncouplings of other membrane proteins in cells. 相似文献
666.
Phyoe Kyawe Myint Atsushi Ito Michael G. Appiah Gideon Obeng Samuel Darkwah Eiji Kawamoto Arong Gaowa Eun Jeong Park Motomu Shimaoka 《Biochemistry and Biophysics Reports》2021
Irisin, a myokine released from skeletal muscle, has recently been found to act as a ligand for the integrins αVβ5, αVβ1, and α5β1 expressed on mesenchymal cells, thereby playing an important role in the metabolic remodeling of the bone, skeletal muscle and adipose tissues. Although the immune-modulatory effects of irisin in chronic inflammation have been documented, its interactions with lymphocytic integrins have yet to be elucidated. Here, we show that irisin supports the cell adhesion of human and mouse lymphocytes. Cell adhesion assays using a panel of inhibitory antibodies to integrins have shown that irisin-mediated lymphocyte adhesion involves multiple integrins including not only α4β1 and α5β1, but also leukocyte-specific αLβ2 and α4β7. Importantly, mouse lymphocytic TK-1 cells that lack the expression of β1 integrins have exhibited αLβ2- and α4β7-mediated cell adhesion to irisin. Irisin has also been demonstrated to bind to purified recombinant integrin αLβ2 and α4β7 proteins. Thus, irisin represents a novel ligand for integrin αLβ2 and α4β7, capable of supporting lymphocyte cell adhesion independently of β1 integrins. These results suggest that irisin may play an important role in regulating lymphocyte adhesion and migration in the inflamed vasculature. 相似文献
667.
Methyl d-pyroglutamate, d-III-A, is hydrolyzed by α-chymotrypsin, and the l-enantiomer is not. Methyl α-methylpyroglutamate, III-B, and methyl α-benzylpyroglutamate, III-C, are hydrolyzed by α-chymotrypsin with d-preference based on the glutamic structure, l-preference based on the alanine and phenylalanine structures. γ-Carbomethoxy-γ-valerolactone, IV, is hydrolyzed without stereoselectivity. Kinetics of hydrolysis of the substrates are reported. Modes of association of the substrates with the active site and the relevance of these results to the reactive orientation of the α-acylamido and hydrolyzing groups of noncyclized substrates are discussed. 相似文献
668.
Reaching movement is a fast movement towards a given target. The main characteristics of such a movement are straight path
and a bell-shaped speed profile. In this work a mathematical model for the control of the human arm during ballistic reaching
movements is presented. The model of the arm contains a 2 degrees of freedom planar manipulator, and a Hill-type, non-linear
mechanical model of six muscles. The arm model is taken from the literature with minor changes. The nervous system is modeled
as an adjustable pattern generator that creates the control signals to the muscles. The control signals in this model are
rectangular pulses activated at various amplitudes and timings, that are determined according to the given target. These amplitudes
and timings are the parameters that should be related to each target and initial conditions in the workspace. The model of
the nervous system consists of an artificial neural net that maps any given target to the parameter space of the pattern generator.
In order to train this net, the nervous system model includes a sensitivity model that transforms the error from the arm end-point
coordinates to the parameter coordinates. The error is assessed only at the termination of the movement from knowledge of
the results.
The role of the non-linearity in the muscle model and the performance of the learning scheme are analysed, illustrated in
simulations and discussed. The results of the present study demonstrate the central nervous system’s (CNS) ability to generate
typical reaching movements with a simple feedforward controller that controls only the timing and amplitude of rectangular
excitation pulses to the muscles and adjusts these parameters based on knowledge of the results. In this scheme, which is
based on the adjustment of only a few parameters instead of the whole trajectory, the dimension of the control problem is
reduced significantly. It is shown that the non-linear properties of the muscles are essential to achieve this simple control.
This conclusion agrees with the general concept that motor control is the result of an interaction between the nervous system
and the musculoskeletal dynamics.
Received : 21 May 1996 / Accepted in revised form : 10 June 1997 相似文献
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